95-15-8, Thianaphthene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
95-15-8, EXAMPLE 11 Preparation of Benzo[b]thiophene-2-carboxaldehyde STR100 Butyllithium (54 mL, 134 mmol) is added dropwise to a solution of N,N,N’,N’-tetramethylethylenediamine (15.57 g, 134 mmol) in tetrahydrofuran under nitrogen at 0 C. The reaction mixture is treated dropwise with a solution of benzothiophene (15.00 g, 112 mmol) in tetrahydrofuran, warmed to room temperature, treated with additional N,N,N’,N’-tetramethylethylenediamine (15.57 g, 134 mmol) and butyllithium (54 mL, 134 mmol), stirred at room temperature for 13 hours, cooled to 0 C., treated with N,N-dimethylformamide (24.40 g, 336 mmol), warmed to room temperature, stirred for five hours, poured into one molar hydrochloric acid and extracted with ether. The combined organic extracts are washed sequentially with water and brine, dried over Na2 SO4 and concentrated in vacuo to obtain an orange oil. Flash chromatography of the oil using silica gel and a 15% ethyl acetate in hexane 25 solution gives the title product as an orange oil (12.51 g, 69%).
The synthetic route of 95-15-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; American Cyanamid Company; US5492925; (1996); A;,
Benzothiophene – Wikipedia
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