5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: General operating procedure: under N2 protection, 20 mL anhydrous tetrahydrofuran was added into the flask containing 2.5 mmol matrine. Then the flask was cooled in icy brine solution for 10-15 min. Next, 5 mmol LDA was added dropwise, following a reaction at room temperature for 30 min. After an icy-salt bath, 5 mmol aromatic aldehyde was added, following a reaction at room temperature for 3 h. Then, a certain amount of water was added for quenching. After the pH value was adjusted to 7-8 by 3N HCl, water of three fold volume was added. Subsequently, the solution obtained was extracted with CH2Cl2, and the extract was detected using thin-layer chromatography (TLC). The organic layer was dried with anhydrous Na2SO4, and concentrated into oily residues. By using ethyl acetate and CH2Cl2 (with the volume ratio of 1:3) as eluant, the residue was purified with silica-gel column chromatography. Finally, the products of 3a~3ac were obtained, with the yields of 32-67%., 5381-20-4
As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.
Reference£º
Article; Li, Zheng; Wu, Lichuan; Cai, Bin; Luo, Mengyang; Huang, Mengtian; Ur Rashid, Haroon; Yang, Yuwen; Jiang, Jun; Wang, Lisheng; Medicinal Chemistry Research; vol. 27; 8; (2018); p. 1941 – 1955;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem