Final Thoughts on Chemistry for Benzo[b]thiophen-5-ol

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NOVEL INHIBITORS OF BETA-LACTAMASE

This invention provides novel beta-lactamase inhibitors of the aryl- and heteroarylsulfonamidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammonium groups. The compounds inhibit three classes of beta-lactamases and synergize the antibacterial effects of beta-lactam antibiotics (e.g., imipenem and ceftazidime) against those micro-organisms normally resistant to the beta-lactam antibiotics as a result of the presence of the Beta-lactamases. Formula (I) or pharmaceutically acceptable salt thereof.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem