Month: May 2021

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 1198-51-2. In a patent，Which mentioned a new discovery about 1198-51-2, molcular formula is C9H6BrClS, introducing its new discovery.

HETEROARYLOXYCARBOCYCLYL COMPOUNDS AS PDE10 INHIBITORS

Heteroaryloxycarbocyclyl compounds of formula (I), and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington¿s Disease, bipolar disorder, obsessive-compulsive disorder, and the like. Formula (I)

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Related Products of 35212-85-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.35212-85-2, Name is Methyl 3-aminobenzo[b]thiophene-2-carboxylate, molecular formula is C10H9NO2S. In a Article，once mentioned of 35212-85-2

[1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HT7 receptor

The present paper describes the synthesis and the binding properties for the serotonergic 5-HT7 and 5-HT1A receptors of three new series (A?C) of (benzo)thienopyrimidinone derivatives. All series exhibit a basic moiety at the 2-position of the heterocyclic scaffold such as N,N-dialkylaminoalkylthio chain in series A and phenylpiperazine, benzylpiperazine, or benzylpiperidine alkyl chain in series B and C. Compounds endowed with the best binding properties at 5-HT7R belong to the B and C types. In particular, derivatives B2 and C1 (RSC4) exhibit notable affinity for 5-HT7R (Ki = 9.08 and 0.85 nM, respectively) and selectivity over the 5-HT1AR (254- and 48-fold, respectively). The structure-affinity relationships for these three new classes of 5-HT7R ligands are discussed and, in order to rationalize and deeply investigate the observed results, molecular modeling studies were performed. In particular, the binding poses of the synthesized compounds were studied by docking them in the two receptor proteins suitably built by homology modeling. The calculated binding energies resulted in an excellent agreement with the experimental measured Ki, further validating the quality of the models.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Reference of 360576-01-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.360576-01-8, Name is Methyl 6-bromobenzo[b]thiophene-2-carboxylate, molecular formula is C10H7BrO2S. In a article，once mentioned of 360576-01-8

COMPOUNDS AND METHODS FOR MODULATING FXR

Compounds of formula. wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Related Products of 14315-11-8, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 14315-11-8, Name is 4-Methylbenzo[b]thiophene,introducing its new discovery.

ALKYLATION OF THIOPHENES AND PREPARATION OF BENZOTHIOPHENES USING MODIFIED MONTMORILLONITE CLAY CATALYSTS

Regioselective benzylation of thiophene and benzothiophene using benzyl chloride and a ZnCl2-promoted montmorillonite catalysts is described.An improved process for the cyclization of (arylthio)acetaldehyde dialkyl acetals to benzothiophenes using the same catalyst is also documented.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Related Products of 35212-85-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.35212-85-2, Name is Methyl 3-aminobenzo[b]thiophene-2-carboxylate, molecular formula is C10H9NO2S. In a article，once mentioned of 35212-85-2

COMPOSITION FOR ORGANIC OPTOELECTRONIC DEVICE AND ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE

Disclosed are a composition for an organic optoelectronic device includes at least one of a first host compound represented by a combination of Chemical Formula 1 and Chemical Formula 2, and at least one of a second host compound represented by a combination of Chemical Formula 3 and Chemical Formula 4, and an organic optoelectronic device including the same, and a display device. Details of Chemical Formulae 1 to 4 are the same as described in the detailed description.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring.Application In Synthesis of 6-Methoxy-2-(4-methoxyphenyl)-1-benzothiophene, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 63675-74-1, Name is 6-Methoxy-2-(4-methoxyphenyl)-1-benzothiophene, molecular formula is C16H14O2S

Anti-mitotic agents which inhibit tubulin polymerization

Methoxy and ethoxy substituted 3-aroyl-2-arylbenzo?b!thiophenes and benzo?b!thiophene analogues are described for use in inhibiting tubulin polymerization. The compounds’ use for treating tumor cells is also described.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application In Synthesis of 6-Methoxy-2-(4-methoxyphenyl)-1-benzothiophene, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 63675-74-1, in my other articles.

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. SDS of cas: 360575-29-7, In an article, mentioned the application of 360575-29-7, Name is Methyl 4-bromobenzo[b]thiophene-2-carboxylate, molecular formula is C10H7BrO2S

Convergent and enantioselective syntheses of cytosolic phospholipase A 2alpha inhibiting N-(1-indazol-1-ylpropan-2-yl)carbamates

Cytosolic phospholipase A2alpha (cPLA2alpha) is an important enzyme of the inflammation cascade. Therefore, inhibitors of cPLA2alpha are assumed to be promising drug candidates for the treatment of inflammatory disorders. Recently we have found that indole-5-carboxylic acid with a 3-(4-octylphenoxy)-2-(phenoxycarbonylamino) propyl substituent in position 1 is an inhibitor of cPLA2alpha. We have now synthesized a corresponding derivative with the indole heterocycle replaced by an indazole (4) employing an analogous reaction sequence as for the synthesis of the indole derivative. Besides, a more convergent synthesis for 4 was established using an aziridine as central intermediate. Furthermore, a chiral-pool based enantioselective synthesis was developed for the synthesis of (R)- and (S)-4. Starting compound for both enantiomers was the (R)-serine derived oxazolidine (R)-25. Compound 4 proved to be a moderate inhibitor of cPLA2alpha, with the S-enantiomer being twice as active as the R-enantiomer. The racemate 4 and the enantiomers (R)- and (S)-4 showed a high in vitro metabolic stability in rat liver S9 fractions. This journal is the Partner Organisations 2014.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. 35212-85-2, name is Methyl 3-aminobenzo[b]thiophene-2-carboxylate. In an article，Which mentioned a new discovery about 35212-85-2, category: benzothiophene.

Synthesis of the HIF-2alpha translation inhibitor compound 76 via a Japp-Klingemann coupling

The Iliopoulos laboratory previously reported the discovery of compound 76, a small molecule HIF2alpha inhibitor. HIF2alpha activation is known to play a critical role in both von Hippel-Lindau (VHL) disease-related tumors and sporadic renal cell carcinoma (RCC). We required a facile and scalable synthetic route to confirm the structure, to investigate the biological properties of compound 76, and to perform structure activity relationship optimization studies. Herein, we report the straightforward synthesis of compound 76 and a preliminary investigation into the scope of the methods developed.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 35212-85-2, and how the biochemistry of the body works.category: benzothiophene

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 5394-13-8, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 5394-13-8

Ruthenium-Catalyzed Direct and Selective C-H Cyanation of N-(Hetero)aryl-7-azaindoles

An efficient, highly regioselective, and scalable ruthenium-catalyzed o-aryl C-H mono-cyanation of N-aryl-7-azaindoles to form N-(2-cyanoaryl)-7-azaindoles has been developed through N-directed ortho C-H activation using N-cyano-N-phenyl-p-toluenesulfonamide as cyanating reagent in the presence of AgOTf and NaOAc in DCE. A range of substrates has furnished cyanated azaindoles in good to excellent yields under the simple reaction conditions. Involvement of C-H metalation has been supported by a kinetic study. This methodology provides easy access to a class of pharmaceutically significant molecules and their precursors.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Reference of 10243-15-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.10243-15-9, Name is 3-Bromo-2-methylbenzo[b]thiophene, molecular formula is C9H7BrS. In a Patent，once mentioned of 10243-15-9

With the Hg2 + And Cys continuous selective asymmetric perfluoro cyclopentene compound and its preparation method and application (by machine translation)

The invention discloses a [1 – [2 – methyl – 3 – benzothienyl], 2 – (2 – methyl – 5 – (4 – phenyl) – (2 – formyl quinoline – 8 – benzothiazolyl) – 3 – thienyl)] full-PVC pentene and its preparation method and application. Preparation method: to benzo thiophene as raw materials, through the iodomethane substituted, brominated, with the perfluoro pentene reaction to generate single substituted perfluoro pentene; to 2 – methyl thiophene as raw materials, bromination, through the n-BuLi and tributyl borate reaction, Stuzki coupling reaction through the end of the with the thiophene ring containing aldehyde group benzene connected, then with ethylene glycol protection after single substituted perfluoro pentene reaction, by reducing dioxiding hydroxy, any change of containing methyl radical bromine, with 8 – hydroxy quinoline – 2 – aldehyde reaction, finally with 2 – amino thiophenol reaction, to obtain the target compound. Prepared by the invention compounds can be used for continuous detection of a specific ion and amino acid, its selectivity is very good. (by machine translation)

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem