Month: August 2021

4923-87-9, Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In a article, 4923-87-9, molcular formula is C8H5BrS, introducing its new discovery.

The purpose of the present invention is to provide a method for easily producing a fluorine-containing (cyclo)alkenyl zinc halide compound at low cost. The present invention provides a method for producing a fluorine-containing (cyclo)alkenyl zinc halide compound represented by formula (1) (wherein A1 represents a perfluoroalkyl group having 1-12 carbon atoms, or a fluorine atom; A2 represents a fluorine atom or a hydrogen atom; A3 represents a fluorine atom or a hydrogen atom, or alternatively A3 and A1 or A2 may combine together to form a perfluoroalkylene chain having 1-12 carbon atoms; and X’ represents a halogen atom), which comprises a step wherein a fluorine-containing olefin represented by formula (2) (wherein X” represents a fluorine atom or a chlorine atom; and the other symbols are as defined above) is reacted with a zinc halide represented by formula ZnX’2 (wherein the symbol is as defined above) in the presence of one or more metals that are selected from among magnesium and magnesium alloys.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Electric Literature of 35212-85-2, Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In a article, 35212-85-2, molcular formula is C10H9NO2S, introducing its new discovery.

Two new series of inhibitors of tubulin polymerization based on the 2-(alkoxycarbonyl)-3-(3?,4?,5?-trimethoxyanilino)benzo[b] thiophene and thieno[2,3-b]pyridine molecular skeletons were synthesized and evaluated for antiproliferative activity on a panel of cancer cell lines, inhibition of tubulin polymerization, cell cycle effects, and in vivo potency. Antiproliferative activity was strongly dependent on the position of the methyl group on the benzene portion of the benzo[b]thiophene nucleus, with the greatest activity observed when the methyl was located at the C-6 position. Also, in the smaller thieno[2,3-b]pyridine series, the introduction of the methyl group at the C-6 position resulted in improvement of antiproliferative activity to the nanomolar level. The most active compounds (4i and 4n) did not induce cell death in normal human lymphocytes, suggesting that the compounds may be selective against cancer cells. Compound 4i significantly inhibited in vivo the growth of a syngeneic hepatocellular carcinoma in Balb/c mice.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 35212-85-2. In my other articles, you can also check out more blogs about 35212-85-2

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. name: 5-Bromobenzothiophene, C8H5BrS. A document type is Article, introducing its new discovery., name: 5-Bromobenzothiophene

The development of the oxidative cross-coupling of unreactive C(sp3)-H bonds with (hetero)arene C(sp2)-H bonds is considerably appealing, yet conceptually and practically challenging. Here, we disclose the rhodium-catalyzed oxidative heteroarylation of unactivated C(sp3)-H bonds with heteroarene C(sp2)-H bonds. This method provides a step-economic route to beta-heteroarylated 2-ethylpyridine derivatives, which exhibits relatively broad substrate scope, high tolerance level of sensitive functional groups, and high selectivity. The protocol can also be extended to the coupling reaction between 8-methylquinoline derivatives and heteroarenes.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Related Products of 35212-85-2, New research progress on 35212-85-2 in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. In a article, 35212-85-2, molcular formula is C10H9NO2S, introducing its new discovery.

Phosphodiesterase (PDE) 7 is a high affinity cAMP-specific PDE whose functional role in T-cells has been the subject of some controversy. Recent findings on tissue distribution, however, support the hypothesis that PDE7 could be a good target for the treatment of airway diseases, T-cell related diseases or central nervous system (CNS) disorders. Therefore, the identification of selective inhibitors targeted against PDE7 enzyme has become an attractive area of research. We report here the first use of the descriptors generated by the CODES program for ligand-based virtual screening. This program codifies molecules from a topological point of view and the generated descriptors are related to the chemical nature of the atoms, the atomic bonds and the connectivity with the rest of the molecule. They are also able to distinguish among stereoisomers. By using this approach, 173 compounds were codified, and their similarity with the reference compound was analysed. Based on the analysis, new potential PDE7 inhibitors have been identified, synthesized and biologically evaluated confirming that CODES descriptors are valid for ligand-based virtual screening and provided new lead compounds for further optimization as potent and selective PDE7 inhibitors.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Reference of 63675-74-1, New research progress on 63675-74-1 in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. In a article, 63675-74-1, molcular formula is C16H14O2S, introducing its new discovery.

The synthesis of benzothiophenes containing a piperazine side chain and their binding affinities for estrogen receptors are described. These compounds bearing piperazine side chains were identified to be high-affinity ligands with high selectivity for ER alpha subtype. They were also potent agonists in bone tissue.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

New Advances in Chemical Research in 2021. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. category: benzothiophene, In an article, mentioned the application of 4923-87-9, Name is 5-Bromobenzothiophene, molecular formula is C8H5BrS

A range of bench-stable carbazole-containing hypervalent iodine(III) reagents were synthesized by I ? N bond formation in good yields. This kind of benziodoxolone reagents was used for a C[sbnd]N coupling reaction to introduce a carbazole group to aromatic heterocycle compounds.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthetic Route of 1196-19-6, Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In a article, 1196-19-6, molcular formula is C9H7BrS, introducing its new discovery.

[1]Benzothienoindolizidinones 5ac,ae,bc and [1]Benzothienoquinolizidinone 5ad were synthesized from 2(3)-bromethyl[1]benzothiophene and methyl prolinate, methyl oxoprolinate and ethyl pipecolinate. The Schmidt rearrangement of ketones 5 led exclusively to the [1,3]diazepines derivatives 6.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1196-19-6

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthetic Route of 5394-13-8, Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In a article, 5394-13-8, molcular formula is C8H5BrS, introducing its new discovery.

A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to amino or pyridylamino cyclobutane derivatives.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

New Advances in Chemical Research in 2021. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. Recommanded Product: 310466-38-7, In an article, mentioned the application of 310466-38-7, Name is 4-Fluorobenzo[b]thiophene, molecular formula is C8H5FS

Potent 5-HT1A/SSRIs at low nanomolar and subnanomolar concentrations were identified in a series of 1-(1H-indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols. Incorporation of an alpha-Me group in the piperidine ring with its specific stereochemistry enhanced binding affinity at the 5-HT reuptake site and in vitro 5-HT1A antagonist functional activity.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

360575-29-7, Chemical Research Letters, May 2021. Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage, causing turnover rates to depend strongly on interfacial structure. In a article, 360575-29-7, molcular formula is C10H7BrO2S, introducing its new discovery.

The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 is a C6-C14 aromatic cyclic hydrocarbon group etc.; R2, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C1-C6 alkylene group etc.; X is a single bond, or a group represented by -CO-NH- or -NH-CO-, etc.; and Y is a C3-C8 cycloalkyl group, a C6-C14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.360575-29-7, you can also check out more blogs about360575-29-7

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem