So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Mennie, Katrina M.; Vara, Brandon A.; Levi, Samuel M. researched the compound: Methyl 3-bromopropanoate( cas:3395-91-3 ).Related Products of 3395-91-3.They published the article 《Reductive sp3-sp2 Coupling Reactions Enable Late-Stage Modification of Pharmaceuticals》 about this compound( cas:3395-91-3 ) in Organic Letters. Keywords: chloroaminopyrimidine bromide alkyl halide chemoselective cross electrophile reductive coupling. We’ll tell you more about this compound (cas:3395-91-3).
Late-stage derivatization of pharmaceutically relevant scaffolds relies on the availability of highly functional-group tolerant reactions. Reactions that increase the sp3 character of mols. enable the pursuit of more selective and well-tolerated pharmaceuticals. Herein, we report the use of sp3-sp2 cross-electrophile reductive couplings to modify a generic ATP-competitive kinase inhibitor with a broad range of primary and secondary alkyl halide coupling partners.
As far as I know, this compound(3395-91-3)Related Products of 3395-91-3 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem