Introduction of a new synthetic route about 3395-91-3

Compounds in my other articles are similar to this one(Methyl 3-bromopropanoate)Electric Literature of C4H7BrO2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3395-91-3, is researched, SMILESS is O=C(OC)CCBr, Molecular C4H7BrO2Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Medicinal Chemistry called Design, Synthesis, and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo, Author is Hao, Er-Jun; Li, Gong-Xin; Liang, Yu-Ru; Xie, Ming-Sheng; Wang, Dong-Chao; Jiang, Xiao-Han; Cheng, Jia-Yi; Shi, Zhi-Xian; Wang, Yang; Guo, Hai-Ming, the main research direction is colon cancer drug discovery anticancer acyclic nucleoside synthesis chloropurinyldodecanol; structure activity antitumor acyclic nucleoside synthesis human apoptosis.Electric Literature of C4H7BrO2.

In the present work, 103 novel acyclic nucleosides were designed, synthesized, and evaluated for their anticancer activities in vitro and in vivo. The structure-activity relationship (SAR) studies revealed that most target compounds inhibited the growth of colon cancer cells in vitro, of which (chloro-9H-purinyl)dodecanol I exhibited the most potent effect against the HCT-116 and SW480 cells with IC50 values of 0.89 and 1.15μM, resp. Furthermore, all of the (R)-configured acyclic nucleoside derivatives displayed more potent anticancer activity compared to their (S)-counterparts. Mechanistic studies revealed that compound I triggered apoptosis in the cancer cell lines via depolarization of the mitochondrial membrane and effectively inhibited colony formation. Importantly, I inhibited the growth of the SW480 xenograft in a mouse model with low systemic toxicity. These results indicated that acyclic nucleoside compounds are viable as potent and effective anticancer agents, and I may serve as a promising lead compound that merits further attention in future anticancer drug discovery.

Compounds in my other articles are similar to this one(Methyl 3-bromopropanoate)Electric Literature of C4H7BrO2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem