On November 30, 2010, Hanna-Elias, Amir; Manallack, David T.; Levit, Alla; Nguyen, William; Ayad, Fadi; Perera, Glen; Shapiro, Marina; Irving, Helen R.; Coupar, Ian M.; Iskander, Magdy N. published an article.Related Products of 16296-68-7 The title of the article was Synthesis, testing and structure-activity studies on a library of 5-HT4 ligands. And the article contained the following:
Several indole derivatives and analogs comprising a range of related structural classes were designed, synthesized and tested as ligands for the 5-HT4 receptor. Within each series, binding experiments showed compounds with good affinity demonstrating high percentage displacement values at 1 μM. The most potent of these (I) had a pKi of 8.54 demonstrating very good affinity. These indole analogs were combined with 55 ligands that were previously produced to explore the structure-activity relationships of these 5-HT4 ligands. A CoMFA (Comparative Mol. Field Anal.) anal. was used to extend an earlier simple pharmacophore to suggest two new mol. features beyond the primary amino binding site. The pharmacophore confirmed that a newly described tetrahydroquinoline analog was able to match the basic requirements of the model and the pharmacol. of this mol. is provided in more detail. The experimental process involved the reaction of 5-Chlorobenzo[b]thiophene-3-carbaldehyde(cas: 16296-68-7).Related Products of 16296-68-7
The Article related to indole derivative preparation 5ht4 ligand structure activity relationship pharmacophore, comparative mol field analysis indole derivative serotonin receptor binding, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 16296-68-7
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem