Design, synthesis, and evaluation of novel 3,4-isoxazolediamide derivatives for the combination treatment of azole-resistant candidiasis was written by Liu, Lei;Sun, Yixiang;Gao, Zixuan;Yin, Wenbo;Jiang, Hong;Wu, Tianxiao;Sun, Yin;Qin, Qiaohua;Zhao, Dongmei;Cheng, Maosheng. And the article was included in Archiv der Pharmazie (Weinheim, Germany).SDS of cas: 70060-13-8 This article mentions the following:
Herein, the structural optimization and structure-activity relationship studies of 3,4-isoxazolediamide analogs I [R1 = 4-FC6H4, 3-isoxazole, benzo(b)thien-2-yl, etc.] and II [R2 = NHMe, NH(i-Pr), NMe2, etc.] were reported. As a new class of fungal Hsp90 inhibitor, compound I [R1 = 5-(morpholinomethyl)isoxazol-3-yl] was found to have good synergistic effects with fluconazole and to avoid potential mammalian toxicity. It also showed remarkable metabolic stability in vitro. Collectively, compound I [R1 = 5-(morpholinomethyl)isoxazol-3-yl] could be a promising lead compound for drug discovery targeting fungal Hsp90 and deserves further investigation. In the experiment, the researchers used many compounds, for example, 5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8SDS of cas: 70060-13-8).
5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.SDS of cas: 70060-13-8
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem