Efficient synthesis of 2,3-diarylbenzo[b]thiophene molecules through palladium (0) Suzuki-Miyaura cross-coupling reaction and their antithrombolytic, biofilm inhibition, hemolytic potential and molecular docking studies was written by Sial, Nosheen;Rasool, Nasir;Rizwan, Komal;Altaf, Ataf Ali;Ali, Shaukat;Malik, Ayesha;Zubair, Muhammad;Akhtar, Arusa;Kausar, Samia;Shah, Syed Adnan Ali. And the article was included in Medicinal Chemistry Research in 2020.Reference of 6287-82-7 This article mentions the following:
A series of 2,3-diaryldibenzo[b]thiophene derivatives I [R = 4-(methylsulfanyl)phenyl, 3-chloro-4-fluorophenyl, 5-methylthiophen-2-yl, etc.] have been synthesized via Suzuki coupling reactions in moderate to good yields (59-79%). The synthesized compounds I were evaluated for their antithrombolytic, biofilm inhibition, and hemolytic potential. All compounds I showed significant biol. potential. Compound I [R = 3-cyano-4-(trifluoromethyl)phenyl] revealed excellent antithrombolytic (87.24%) and biofilm inhibition (99.64%) activity. Compound I (R = 4-methoxyphenyl) exhibited an outstanding hemolytic potential (84.53%). The docking studies uncovered that studied compounds interact with streptokinase and plasminogen via hydrogen bonding, π-anion, π-π stacked interactions, and π-sigma bonding type interactions. The results revealed that synthesized benzo[b]thiophene derivatives I could be a potential source of therapeutic agents. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Reference of 6287-82-7).
2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is also used in the manufacturing of dyes such as thioindigo.Reference of 6287-82-7
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem