Mechanistic Switch in Dual Gold Catalysis of Diynes: C(sp3)-H Activation through Bifurcation-Vinylidene versus Carbene Pathways was written by Hansmann, Max M.;Rudolph, Matthias;Rominger, Frank;Hashmi, A. Stephen K.. And the article was included in Angewandte Chemie, International Edition in 2013.Recommanded Product: 2,3-Dibromobenzo[b]thiophene This article mentions the following:
Gold-catalyzed cycloisomerization of 2,3-diethynylthiophenes with terminal CC bond to give indanothiophenes and fluorenothiophenes. E.g., reaction of 2-ethynyl-3-(oct-1-yn-1-yl)thiophene and 5 mol% IPrAuNTf2 (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene, Tf = trifluoromethylsulfonyl) in dry toluene at 70° gave 7-propyl-6,7-dihydro-5H-indeno[5,6-b]thiophene in 54% yield. Variation of the backbone of the diyne system opens up a pathway for the intramol. C(SP3)-H activation event. Based on theor. work it is postulated that a switch in selectivity along a bifurcation pathway, for the first time leading to products through σ,π dual activation and a 6-endo diyne cyclization. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Recommanded Product: 2,3-Dibromobenzo[b]thiophene).
2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Recommanded Product: 2,3-Dibromobenzo[b]thiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem