Dual Gold Catalysis: Bidirectional Processes and Tandem sp3-C-H Insertion Reactions was written by Tsupova, Svetlana;Rudolph, Matthias;Rominger, Frank;Hashmi, A. Stephen K.. And the article was included in Chemistry – A European Journal in 2017.Synthetic Route of C8H4Br2S This article mentions the following:
Various tetrayne systems were converted under dual gold-catalyzed conditions. For sym. tetraalkynyl-substituted thiophenes, bearing two alkyl-substituted alkynes and two terminal alkyne units, bidirectional cyclizations led to the efficient formation of dibenzothiophene systems. In all cases, selective C-H activation of the C-H bond of the alkyl substituent was observed leading to cyclopentane moieties annelated to the newly formed aromatic cores. If two thiophene moieties were tethered over the attached non-terminal alkynes, depending on the length of the connecting alkyl tether, either bidirectional processes or tandem processes can be addressed leading to interesting mol. structures, such as spiro compounds or isolated benzothiophenes connected by a C-C bond. Other electron-rich heterocycles also reacted. While the reactions even worked for some mixed systems, other cases only delivered the products of a mono-cyclization. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Synthetic Route of C8H4Br2S).
2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Synthetic Route of C8H4Br2S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem