Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3 was written by Patch, Raymond J.;Baumann, Christian A.;Liu, Jian;Gibbs, Alan C.;Ott, Heidi;Lattanze, Jennifer;Player, Mark R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Computed Properties of C13H16N2O2S This article mentions the following:
A series of 2-acylaminothiophene-3-carboxamides has been identified which exhibit potent inhibitory activity against the FLT3 tyrosine kinase. Compound 44 inhibits the isolated enzyme (IC50 = 0.027 μM) and blocks the proliferation of MV4-11 cells (IC50 = 0.41 μM). Structure-activity relationship studies within this series are described in the context of a proposed binding model within the ATP binding site of the enzyme. In the experiment, the researchers used many compounds, for example, Ax20017 (cas: 329221-38-7Computed Properties of C13H16N2O2S).
Ax20017 (cas: 329221-38-7) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Computed Properties of C13H16N2O2S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem