Palladium-Catalyzed Alkynylation of Enones with Alkynylsilanes via C-C Bond Activation was written by Liu, Yu-Wen;Li, Ling-Jun;Xu, Hui;Dai, Hui-Xiong. And the article was included in Journal of Organic Chemistry in 2022.SDS of cas: 4298-52-6 This article mentions the following:
The synthesis of 1,3-enynes via palladium-catalyzed cross coupling between enone derivatives and alkynylsilanes was reported. The employment of appropriate pyridine-oxazoline ligand is the key to the C-C cleavage and the high E/Z stereoselectivity. This protocol features broad substrate scope and wide functional-group tolerance, affording the desired products in moderate-to-good yields. Late-stage diversification of natural product β-ionone further demonstrated the synthetic utility of this protocol. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6SDS of cas: 4298-52-6).
2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.SDS of cas: 4298-52-6
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem