Synthesis and studies on antidepressant and anticonvulsant activities of some 3-(2-thienyl)pyrazoline derivatives was written by Ozdemir, Zuhal;Kandilci, H. Burak;Gumusel, Bulent;Calis, Unsal;Bilgin, A. Altan. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2008.Reference of 3988-77-0 This article mentions the following:
In this study, the synthesis of twelve 3-(2-thienyl)pyrazoline derivatives are described. The structures of all compounds were confirmed by UV, IR, 1H-NMR, mass spectral data, and microanalyses. In the pharmacol. studies, antidepressant and anticonvulsant activities of these compounds have been screened. The antidepressant activities of the compounds were investigated by Porsolt’s behavioral despair test (forced swimming) on albino mice and compared with tranylcypromine. Among the compounds examined, the compounds I (R1 = 2-thienyl; R2 = Me, Ph) showed significant antidepressant activity. Anticonvulsant activities of the compounds were determined by maximal electroshock seizure (MES) and s.c. pentylenetetrazole (metrazol) (scMet.) tests, neurotoxicities were determined by rotarod toxicity test on albino mice. Compound I (R1 = R2 = Ph) was found to be protective against MES in the range of 30-300 mg/kg dose levels at four hours. None of the synthesized compounds showed neurotoxicity at 30-300 mg/kg dose levels. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Reference of 3988-77-0).
3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is also used in the manufacturing of dyes such as thioindigo.Reference of 3988-77-0
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem