Day: February 23, 2023

Synthesis and evaluation of difluorophosphate salt electrolyte additives for lithium-ion batteries was written by Hall, David S.;Hynes, Toren;Aiken, Connor P.;Dahn, J. R.. And the article was included in Journal of the Electrochemical Society in 2020.Name: 1,3,2-Dioxathiolane 2,2-dioxide This article mentions the following:

The electrolyte additive lithium difluorophosphate improves the lifetime of lithium-ion cells. This work presents the synthesis and evaluation of alternative difluorophosphate salt electrolyte additives. Ammonium difluorophosphate is readily prepared via a solidstate, benchtop reaction of ammonium fluoride and phosphorus pentoxide that requires only gentle heating to initiate. The best yield of sodium difluorophosphate (NaFO) in the present study was obtained by reacting difluorophosphoric acid and sodium carbonate in 1,2-diemethoxyethane over 3 Å mol. sieves. Tetramethylammonium difluorophosphate was prepared from NaFO via cation-exchange with tetramethylammonium chloride. NaFO is here reported to be a very good electrolyte additive, with similar performance in NMC532/graphite pouch cells as the lithium salt. The benefi cial nature of both additives is attributable to the difluorophosphate anion. In contrast, ammonium and tetramethylammonium difluorophosphates are found to be poor electrolyte additives. For the former, this is suggested to be due to the formation of lithium nitride and hydrogen gas. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Name: 1,3,2-Dioxathiolane 2,2-dioxide).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Name: 1,3,2-Dioxathiolane 2,2-dioxide

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Development and validation of an HPLC method with fluorescence detection for the determination of fluorescent whitening agents migrating from plastic beverage cups was written by Alberto Lopes, Joao F.;Tsochatzis, Emmanouil D.;Emons, Hendrik;Hoekstra, Eddo. And the article was included in Food Additives & Contaminants, Part A in 2018.Application of 7128-64-5 This article mentions the following:

An HPLC method with fluorescence detection has been developed and validated for the quantification of six fluorescent whitening agents (FWA) in plastic beverage cups after extraction and in food simulants after migration at 70°C for 2 h. The sensitivity of the method was high with LODs ranging from 0.053 to 0.251 μg kg^-1 and LOQs from 0.107 to 0.504 μg kg^-1. Accuracy and precision were highly acceptable, with recoveries greater than 82% and RSDs (%) below 16%. The expanded combined uncertainty was found to be less than 23% for the measurements of all studied FWAs. In extracting the analytes from food contact materials (FCM), accelerated solvent extraction (ASE) and Soxhlet extraction were applied using ethanol as the extraction solvent. The results obtained for FWA in 10 different food plastic cups, made from different polymers, were compared. The ASE technique proved to be faster, more effective and efficient than Soxhlet extraction Migration tests with official food simulants from Regulation (EU) No 10/2011 showed that the substances studied could potentially migrate using the selected migration conditions. The most pronounced effect was observed in case of simulant D1 (50% w/v ethanol in water). The anal. method proved to be a simple, fast, sensitive and reliable tool for the simultaneous quantification of six of the most used FWAs in both FCM extracts and food simulants after migration experiments In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Application of 7128-64-5).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Application of 7128-64-5

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A₃ adenosine receptor agonists containing dopamine moieties for enhanced inter-species affinity was written by Tosh, Dilip K.;Salmaso, Veronica;Campbell, Ryan G.;Rao, Harsha;Bitant, Amelia;Pottie, Eline;Stove, Christophe P.;Liu, Naili;Gavrilova, Oksana;Gao, Zhan-Guo;Auchampach, John A.;Jacobson, Kenneth A.. And the article was included in European Journal of Medicinal Chemistry in 2022.Name: 2-Ethynylthiophene This article mentions the following:

Following our study of 4′-truncated (N)-methanocarba-adenosine derivatives that displayed unusually high mouse (m) A₃AR affinity, we incorporated dopamine-related N⁶ substituents in the full agonist 5′-methylamide series. N⁶-(2-(4-Hydroxy-3-methoxy-phenyl)ethyl) derivative MRS7618 I displayed K_i (nM) 0.563 at hA₃AR (∼20,000-fold selective) and 1.54 at mA₃AR. 2-Alkyl ethers maintained A₃ affinity, but with less selectivity than 2-alkynes. Parallel functional assays of G protein-dependent and β-arrestin 2 (βarr2)-dependent pathways indicate these are full agonists but not biased. Through use of computational modeling, we hypothesized that Ph OH/OMe groups interact with polar residues, particularly Gln261, on the mA₃AR extracellular loops as the basis for the affinity enhancement. Although the pharmacokinetic indicated facile clearance of parent O-Me catechol nucleosides, prolonged mA₃AR activation in vivo was observed in a hypothermia model, suggested potential formation of active metabolites through demethylation. Selected analogs induced mouse hypothermia following i.p. injection, indicative of peripheral A₃AR agonism in vivo. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Name: 2-Ethynylthiophene).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Name: 2-Ethynylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Incorporation of Fluorescent Dyes in Atmospheric Pressure Plasma Coatings for In-Line Monitoring of Coating Homogeneity was written by Somers, Wesley;Dubreuil, Marjorie F.;Neyts, Erik C.;Vangeneugden, Dirk;Bogaerts, Annemie. And the article was included in Plasma Processes and Polymers in 2014.Quality Control of 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene This article mentions the following:

This paper reports on the incorporation of three com. fluorescent dyes, i.e., rhodamine 6G, fluorescein, and fluorescent brightener 184, in plasma coatings, by utilizing a dielec. barrier discharge (DBD) reactor, and the subsequent monitoring of the coatings homogeneity based on the emitted fluorescent light. The plasma coatings are qual. characterized with fluorescence microscopy, UV-vis spectroscopy and profilometry for the determination of the coating thickness. The emitted fluorescent light of the coating correlates to the amount of dye per area, and deviations of these factors can hence be observed by monitoring the intensity of this light. This allows monitoring the homogeneity of the plasma coatings in a fast and simple way, without making major adjustments to the process. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Quality Control of 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Quality Control of 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Direct synthesis of 1-naphthylamines enabled by 6-endo-dig cyclization strategy using copper catalysis was written by Ma, Peng;Wang, Jianhui;Liu, Guiyan. And the article was included in Applied Organometallic Chemistry in 2022.Category: benzothiophene This article mentions the following:

A facile approach for the synthesis of substituted 1-naphthylamines I [R¹ = Ph, 2-FC₆H₄, 3-ClC₆H₄, etc.; R² = H, 7-F, 6-Cl, etc.; R³ = H, CH₂CH=CH₂; R⁴ = Ph, Bn, Cy, etc.; R³ = R⁴ = Me; R³R⁴ = CH₂CH₂OCH₂CH₂] via three-component 6-endo-dig cyclization of terminal alkynes with 2-bromoaryl ketones, primary or secondary amines in water under Pd-free conditions was described. The Cu(I) catalytic system avoided a fundamental problem related to these substrates, which competitively evolve through 5-endo-dig cyclization pathways under metal catalysis. This unique performance unlocked a rapid access to a diverse 1-naphthylamines library that previously required longer synthetic routes. The synthetic potential of this method was further demonstrated by the gram-scale synthesis, and the mechanism study showed that the reaction experienced sequential halide exchange, imine-enamine tautomerization and 6-endo-dig cyclization. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0Category: benzothiophene).

3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and evaluation of dual wavelength fluorescent benzo[b]thiophene boronic acid derivatives for sugar sensing was written by Akay, Senol;Yang, Wenqian;Wang, Junfeng;Lin, Li;Wang, Binghe. And the article was included in Chemical Biology & Drug Design in 2007.HPLC of Formula: 1000160-75-7 This article mentions the following:

Cell surface glycoproteins have been known to play very important roles in various physiol. and pathol. processes. Small mol. compounds capable of carbohydrate recognition can be very useful for the development of sensing, diagnostic, and therapeutic agents. Along this line, the authors are interested in developing water-soluble fluorescent boronic acid compounds for carbohydrate recognition. As such, a series of benzo[b]thiophene boronic acid derivatives have been synthesized and their fluorescent properties analyzed at physiol. pH. Benzo[b]thiophene derivatives were a new type of fluorescent reporter compounds capable of dual fluorescent emission under physiol. pH conditions. Many of the synthesized Compounds showed unusual emission wavelength shifts upon binding of sugars. These boronic acids will be useful tools for building glycoprotein biosensors for biol. applications. In the experiment, the researchers used many compounds, for example, 2-(Benzo[b]thiophen-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 1000160-75-7HPLC of Formula: 1000160-75-7).

2-(Benzo[b]thiophen-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 1000160-75-7) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.HPLC of Formula: 1000160-75-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A Transmetalation Reaction Enables the Synthesis of [¹⁸F]5-Fluorouracil from [¹⁸F]Fluoride for Human PET Imaging was written by Hoover, Andrew J.;Lazari, Mark;Ren, Hong;Narayanam, Maruthi Kumar;Murphy, Jennifer M.;van Dam, R. Michael;Hooker, Jacob M.;Ritter, Tobias. And the article was included in Organometallics in 2016.Name: Benzo[b]thiophen-3-ylboronic acid This article mentions the following:

Translation of new ¹⁸F-fluorination reactions to produce radiotracers for human positron emission tomog. (PET) imaging is rare because the chem. must useful scope and the process for ¹⁸F-labeled tracer production must be robust and simple to execute. The application of transition metal mediators has enabled impactful ¹⁸F-fluorination methods, but to date none of these reactions were applied to produce a human-injectable PET tracer. The authors present chem. and process innovations that culminate in the 1st production from [¹⁸F]fluoride of human doses of [¹⁸F]5-fluorouracil, a PET tracer for cancer imaging in humans. The 1st preparation of Ni σ-aryl complexes by transmetalation from arylboronic acids or esters was developed, and enabled the synthesis of the [¹⁸F]5-fluorouracil precursor. Routine production of >10 mCi doses of [¹⁸F]5-fluorouracil was accomplished with a new instrument for azeotrope-free [¹⁸F]fluoride concentration in a process that leverages the tolerance of H₂O in Ni-mediated ¹⁸F-fluorination. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Name: Benzo[b]thiophen-3-ylboronic acid).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Name: Benzo[b]thiophen-3-ylboronic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Gold-catalyzed intermolecular alkyne oxyarylation for C3 functionalization of benzothiophenes was written by Rist, Paige A.;Grainger, Richard S.;Davies, Paul W.. And the article was included in Organic Letters in 2021.Application of 1195-14-8 This article mentions the following:

C3-selective C-C bond formation on benzothiophenes is challenging, and few direct functionalization methods are available. A gold-catalyzed reaction of alkynes with benzothiophene S-oxides provides regioselective entry into C3-alkylated benzothiophenes with the C7-alkylated isomer as the minor product. This oxyarylation reaction works with alkyl and aryl alkynes and substituted and unsubstituted benzothiophenes. Mechanistic studies identify that sulfoxide inhibits the catalyst [DTBPAu(PhCN)]SbF₆, which also degrades and forms the unreactive complex [(DTBP)₂Au]SbF₆. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Application of 1195-14-8).

2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Application of 1195-14-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Impact of functionalization and co-additives on dioxazolone electrolyte additives was written by Gauthier, Roby;Hall, David S.;Lin, Katherine;Baltazar, Jazmin;Hynes, Toren;Dahn, J. R.. And the article was included in Journal of the Electrochemical Society in 2020.HPLC of Formula: 1072-53-3 This article mentions the following:

Finding new electrolyte additives could help create lithium-ion batteries with better performance at high voltage, allowing higher energy d. However, finding the perfect additive remains a tremendous challenge, since researchers still don’t understand how to predict their performance. A new group of dioxazolone electrolyte additives have been tested in lithium-ion batteries alone or in combination with well-known co-additives. The new additives consist of a 3-phenyl-1,4,2-dioxazol-5-one (PDO) parent structure with or without (methoxy, fluoro and nitro) functional groups on the para position of the Ph ring. It is found that PDO (no functional group) and p-(4-nitrophenyl)-1,4,2-dioxazol-5-one (pNDO) are the best performing dioxazolones overall and show promising results. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3HPLC of Formula: 1072-53-3).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.HPLC of Formula: 1072-53-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Simultaneous determination of fluorescent whitening agents (FWAs) and photoinitiators (PIs) in food packaging coated paper products by the UPLC-MS/MS method using ESI positive and negative switching modes was written by Wu, Zhijiang;Xu, Yansheng;Li, Mianchang;Guo, Xindong;Xian, Yanping;Dong, Hao. And the article was included in Analytical Methods in 2016.Application of 7128-64-5 This article mentions the following:

A sensitive ultra-high performance liquid chromatog. tandem mass spectrometry (UPLC-MS/MS) method was established for the simultaneous determination of fluorescent whitening agents (FWAs) and photoinitiators (PIs) in food packaging coated paper products. Samples were firstly soaked in water and then ultrasonically extracted by using methanol-trichloromethane. The extraction solution was subsequently separated by using a Phenomenex Luna C18 (2) chromatog. column (50 mm × 2.00 mm, 3 μm) using methanol-5 mmol L^-1 ammonium acetate as the mobile phase. The target analytes were ionized by the ESI pos. and neg. switching modes and detected using the multiple-reaction monitoring (MRM) mode. The method was validated for linearity and range, accuracy, precision and sensitivity. Under the optimized conditions, the calibration curves were linear over the selected concentration ranges of 10-1000 μg L^-1 and 0.5-50 μg L^-1 for four FWAs (FWA28, FWA85, FWA71 and FWA351) and the rest of the ten compounds, resp., with calculated coefficients of determination (R²) greater than 0.99. The instrument limit of quantitation (ILOQ) and the corresponding method limit of quantitation (MLOQ) of fourteen target analytes were in the range of 0.5-10 μg L^-1 and 6-125 μg kg^-1, resp. Recoveries were calculated at three levels of concentration spiked into neg. samples and the values were found between 79.2% and 115% with relative standard deviation (RSD) values of 3.2-12.3% for intra-day precision (n = 6) and 4.5-11.5% for inter-day precision (n = 5) 2.5-7.2%. The method was successfully applied to analyze twenty-five food packaging coated paper product samples and FWA184 and 4-MBP were detected in only two samples with the concentrations of 151 μg kg^-1 and 32 μg kg^-1, resp. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Application of 7128-64-5).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Application of 7128-64-5

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem