Day: February 23, 2023

Shielding Effect of Nanomicelles: Stable and Catalytically Active Oxidizable Pd(0) Nanoparticle Catalyst Compatible for Cross-Couplings of Water-Sensitive Acid Chlorides in Water was written by Ansari, Tharique N.;Sharma, Sudripet;Hazra, Susanta;Jasinski, Jacek B.;Wilson, Andrew J.;Hicks, Frederick;Leahy, David K.;Handa, Sachin. And the article was included in JACS Au in 2021.Synthetic Route of C8H7BO2S This article mentions the following:

Under the shielding effect of nanomicelles, a sustainable micellar technol. for the design and convenient synthesis of ligand-free oxidizable ultrasmall Pd(0) nanoparticles (NPs) and their subsequent catalytic exploration for couplings of water-sensitive acid chlorides in water is reported. A proline-derived amphiphile, PS-750-M, plays a crucial role in stabilizing these NPs, preventing their aggregation and oxidation state changes. These NPs were characterized using ¹³C NMR (NMR), IR (IR), and surface-enhanced Raman scattering (SERS) spectroscopy to evaluate the carbonyl interactions of PS-750-M with Pd. High-resolution transmission electron microscopy (HRTEM) and energy-dispersive X-ray spectroscopy (EDX) studies were performed to reveal the morphol., particle size distribution, and chem. composition, whereas XPS measurements unveiled the oxidation state of the metal. In the cross-couplings of water-sensitive acid chlorides with boronic acids, the micelle’s shielding effect and boronic acids plays a vital role in preventing unwanted side reactions, including the hydrolysis of acid chlorides under basic pH. This approach is scalable and the applications are showcased in multigram scale reactions. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Synthetic Route of C8H7BO2S).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Synthetic Route of C8H7BO2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The influence of hydrocarbon compositions of transformer oils on the electrostatic charging tendency was written by Yu, Hui-min;Ma, Shu-jie;Zhang, Qi;Zhang, Ling-jun. And the article was included in Runhuayou in 2010.Application In Synthesis of 3-Ethylthiophene This article mentions the following:

The results of studies on the electrostatic charging tendency of flowing transformer oils for OF-or OD- cooled super high voltage transformers were summarized. The influence of hydrocarbon compositions of transformer oils on the electrostatic charging tendency was studied in detail, in which the electrostatic charging tendency of naphthenic transformer oils with different aromatic hydrocarbons content, and the electrostatic charging tendency of different crude oil style transformer oils with the same aromatic hydrocarbons content were mostly investigated. The influences of the sulfide compounds, the nitride compounds, as well as poly-aromatics content on the electrostatic charging tendency were also studied. It was found that high poly-aromatics content in transformer oils should increase the electrostatic charging tendency of transformer oils. In the experiment, the researchers used many compounds, for example, 3-Ethylthiophene (cas: 1795-01-3Application In Synthesis of 3-Ethylthiophene).

3-Ethylthiophene (cas: 1795-01-3) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application In Synthesis of 3-Ethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A new kind of blue hybrid electroluminescent device was written by Wang, Junling;Li, Zhuan;Liu, Chunmei. And the article was included in Journal of Nanoscience and Nanotechnology in 2016.COA of Formula: C26H26N2O2S This article mentions the following:

Bright blue Electroluminescence come from an ITO/BBOT doped silica (6 × 10^-3 M) made by a sol-gel method/Al driven by AC with 500 Hz at different voltages and Gaussian anal. under 55 V showed that blue emission coincidenced with typical triple emission from BBOT. This kind of device take advantage of organics (BBOT) and inorganics (silica). Electroluminescence from a single-layered sandwiched device consisting of blue fluorescent dye 2,5-bis (5-tert-butyl-2-benzoxazolyl) thiophene (BBOT) doped silica made by sol-gel method was investigated. A number of concentrations of hybrid devices were prepared and the maximum concentration was 6 × 10^-3 M. Blue electroluminescent (EL) always occurred above a threshold field 8.57 × 10⁵ V/cm (30 V) at alternating voltage at 500 HZ. The luminance of the devices increased with the concentration of doped BBOT, but electroluminescence characteristics were different from a single mol.’s photoluminescence properties of triple peaks. When analyzing in detail direct-current electroluminescence devices of pure BBOT, a single peak centered at 2.82 eV appeared with the driven voltage increase, which is similar to the hybrid devices. Comparing Gaussian decomposition date between two kinds of devices, the triple peak characteristic of BBOT was consistent. It is inferred that BBOT contributed EL of the hybrid devices mainly and silica may account for a very small part. Meanwhile the thermal stability of matrix silica was measured by Thermal Gravity-Mass Spectroscopy (TG-MS). There is 12 percent weight loss from room temperature to 1000 °C and silica has about 95% transmittance. So the matric silica played an important role in thermal stability and optical stability for BBOT. In addition, this kind of blue electroluminescence device can take advantages of organic materials BBOT and inorganic materials silica. This is a promising way to enrich EL devices, especially enriching inorganic EL color at a low cost. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5COA of Formula: C26H26N2O2S).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.COA of Formula: C26H26N2O2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and studies on antidepressant and anticonvulsant activities of some 3-(2-thienyl)pyrazoline derivatives was written by Ozdemir, Zuhal;Kandilci, H. Burak;Gumusel, Bulent;Calis, Unsal;Bilgin, A. Altan. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2008.Reference of 3988-77-0 This article mentions the following:

In this study, the synthesis of twelve 3-(2-thienyl)pyrazoline derivatives are described. The structures of all compounds were confirmed by UV, IR, ¹H-NMR, mass spectral data, and microanalyses. In the pharmacol. studies, antidepressant and anticonvulsant activities of these compounds have been screened. The antidepressant activities of the compounds were investigated by Porsolt’s behavioral despair test (forced swimming) on albino mice and compared with tranylcypromine. Among the compounds examined, the compounds I (R¹ = 2-thienyl; R² = Me, Ph) showed significant antidepressant activity. Anticonvulsant activities of the compounds were determined by maximal electroshock seizure (MES) and s.c. pentylenetetrazole (metrazol) (scMet.) tests, neurotoxicities were determined by rotarod toxicity test on albino mice. Compound I (R¹ = R² = Ph) was found to be protective against MES in the range of 30-300 mg/kg dose levels at four hours. None of the synthesized compounds showed neurotoxicity at 30-300 mg/kg dose levels. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Reference of 3988-77-0).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is also used in the manufacturing of dyes such as thioindigo.Reference of 3988-77-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Radical Hydro-Fluorosulfonylation of Unactivated Alkenes and Alkynes was written by Wang, Peng;Zhang, Honghai;Zhao, Mingqi;Ji, Shuangshuang;Lin, Lu;Yang, Na;Nie, Xingliang;Song, Jinshuai;Liao, Saihu. And the article was included in Angewandte Chemie, International Edition in 2022.Safety of 3-Ethynylthiophene This article mentions the following:

Here, reported the first establishment of radical hydro-fluorosulfonylation of alkenes, which was enabled by using 1-fluorosulfonyl 2-aryl benzoimidazolium (FABI) as an effective redox-active radical precursor. This method provided a new and facile approach for the synthesis of aliphatic sulfonyl fluorides from unactivated alkenes, and could be further applied to the late-stage modifications of natural products and peptides, as well as ligation of drugs in combination with click chem. Remarkably, this system could enable the radical hydro-fluorosulfonylation of alkynes, afforded valuable alkenylsulfonyl fluoride products with a rare, high Z-selectivity, which were normally less stable and more challenging to synthesize in comparison with the E-configured products. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0Safety of 3-Ethynylthiophene).

3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is also used in the manufacturing of dyes such as thioindigo.Safety of 3-Ethynylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Regioselective Dichotomy in Ru(II)-Catalyzed C-H Annulation of Aryl Pyrazolidinones with 1,3-Diynes was written by Sontakke, Geetanjali S.;Ghosh, Chiranjit;Pal, Kuntal;Volla, Chandra M. R.. And the article was included in Journal of Organic Chemistry in 2022.SDS of cas: 67237-53-0 This article mentions the following:

Herein, authors present a substrate-controlled regiodivergent strategy for the selective synthesis of C3 or C2-alkynylated indoles via ruthenium-catalyzed [3 + 2]-annulation of readily available pyrazolidinones and 1,3-diynes. Remarkably, C3-alkynylated indoles were obtained in good yields when 1,4-diarylbuta-1,3-diynes were employed as the coupling partners. On the other hand, dialkyl-1,3-diynes led to the selective formation of C2-alkynylated indoles. The key features of the strategy are the operationally simple conditions and external-oxidant-free, broad-scope, and substrate-switchable indole synthesis. Scale-up reactions and further transformations expanded the synthetic utility of the protocol. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0SDS of cas: 67237-53-0).

3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.SDS of cas: 67237-53-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Photocatalytic activity of an Anderson-type polyoxometalate with mixed copper(I)/copper(II) ions for visible-light enhancing heterogeneous catalysis was written by Qin, Lan;Ren, Ran;Huang, Xiaoxue;Xu, Xinyi;Shi, Hao;Huai, Ranran;Song, Nuan;Yang, Lu;Wang, Suna;Zhang, Daopeng;Zhou, Zhen. And the article was included in Journal of Solid State Chemistry in 2022.HPLC of Formula: 67237-53-0 This article mentions the following:

The development of new catalysts that exhibit catalytic activity and enhance the catalysis under light-irradiation could help eliminate the barrier between traditional catalysts and photocatalysts. Herein, an organic-inorganic hybrid Anderson-type polyoxometalate (noted as POM 1) was synthesized by incorporating a [MnMo₆O₁₈] cluster and two rare three-coordinated copper sites, which were connected by the organic [(OCH₂)₃CN=CH-4-Py] (Py = pyridine) moieties on both sides. The resultant POM 1 exhibited an enhanced luminescence property compared with the free [MnMo₆O₁₈] cluster. While in terms of photocatalytic activity, the prepared catalyst exhibited an excellent selective degradation ability toward a pos.-charged methylene blue dye in an aqueous solution Meanwhile, the X-ray photoelectron spectrometry anal. indicated the coexistence of Cu(I)/Cu(II) ions and suggested that the partly oxidized Cu(II) ions in 1 could be reduced to Cu(I) ions via the photoinduced electron transfer from the [MnMo₆O₁₈] unit. This in-situ reduction process provides an enhanced heterogeneous catalytic performance in terms of azide-alkyne cycloaddition, affording almost complete conversion within a 4 h irradiation using a 20 W household incandescent lamp as the light source at room temperature under solvent-free conditions. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0HPLC of Formula: 67237-53-0).

3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.HPLC of Formula: 67237-53-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Proteolytic susceptibility of hemoglobin synthesized in the presence of amino acid analogs was written by Ayukawa, Saburo;Fisher, Joyce M.;Rabinovitz, Marco. And the article was included in Molecular Pharmacology in 1981.Formula: C7H9NO3S This article mentions the following:

α-Amino acid analogs with a hetero atom on the β-C, when incorporated into protein by a reticulocyte lysate, render the newly formed protein particularly sensitive to proteolytic hydrolysis. In the experiment, the researchers used many compounds, for example, 2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid (cas: 32595-59-8Formula: C7H9NO3S).

2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid (cas: 32595-59-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Formula: C7H9NO3S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Niobium(V) oxido tris-carbamate as easily available and robust catalytic precursor for the selective sulfide to sulfone oxidation was written by Bresciani, Giulio;Gemmiti, Mario;Ciancaleoni, Gianluca;Pampaloni, Guido;Marchetti, Fabio;Crucianelli, Marcello. And the article was included in Molecular Catalysis in 2021.HPLC of Formula: 1195-14-8 This article mentions the following:

The oxidation of the sulfide function promoted by a variety of vanadium compounds has been largely explored, whereas the use of homogeneous catalytic systems based on the heavier group 5 metals remains less explored. We report the use of easily available niobium and tantalum carbamates, i.e. [M(O₂CNMe₂)₅] (M = Nb, 1; M = Ta, 2), [Nb(O₂CNMe₂)₄], 3, [NbO(O₂CNEt₂)₃], 4, and [NbCl₃(O₂CNEt₂)₂], 5, as effective catalysts for the conversion of a series of alkyl aryl and aromatic sulfides into the corresponding sulfones. NMR investigations on the performant niobium catalyst 4 unexpectedly revealed the substantial stability of this compound in the protic catalytic environment, and a plausible catalytic cycle was obtained by DFT studies. The two active catalytic species, i.e. 4 and its minor mono-methoxide derivative, presumably interconvert to each other exploiting the versatile coordination of the carbamato ligand. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8HPLC of Formula: 1195-14-8).

2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.HPLC of Formula: 1195-14-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Some derivatives of dibenzothiophene was written by Brown, Robert K.;Christiansen, Robert G.;Sandin, Reuben B.. And the article was included in Journal of the American Chemical Society in 1948.Application of 25288-76-0 This article mentions the following:

Dibenzothiophene (15 g.) in 150 ml. CCl₄, treated at 0-5° with 6 g. Cl and the addition compound hydrolyzed by shaking with ice and H₂O, gives 77% of the 5-oxide (I), m. 185-7°. I (15 g.), 33 ml. AcOH, and 33 ml. concentrated H₂SO₄ at 0° treated (15 min.) with 36 ml. HNO₃ (d. 1.5), kept 30 min. at 0-5°, and poured onto ice, give 76% 3-nitrodibenzothiophene 5-oxide (II), m. 209.5-10.5°. II (10 g.) in 100 ml. AcOH, reduced with 51 g. SnCl₂.2H₂O in 65 ml. concentrated HCl, gives 65% 3-aminodibenzothiophene, m. 121-2.5°. II (5 g.) in 60 ml. AcOH, treated with 26 g. SnCl₂.2H₂O in 40 ml. 6 N HCl, kept 30 min. at 40° and 3 hrs. at room temperature, gives 91% 3-aminodibenzothiophene 5-oxide, light yellow, m. 208-9°; Ac derivative, light yellow, m. 265-7°. In the experiment, the researchers used many compounds, for example, Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0Application of 25288-76-0).

Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Application of 25288-76-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem