Day: February 23, 2023

Nickel-catalyzed deaminative allenylation of amino acid derivatives: Catalytic activity enhanced by an amide-type NN₂ Pincer ligand was written by Zhang, Xingjie;Jiao, Chenchen;Qi, Di;Liu, Xiaopan;Zhang, Zhiguo;Zhang, Guisheng. And the article was included in Organic Letters in 2022.Related Products of 67237-53-0 This article mentions the following:

Herein, we report a general and practical nickel-catalyzed deaminative allenylation of amino acid derivatives with terminal alkynes. The well-designed, electron deficient, and sterically hindered amide-type NN₂ Pincer ligand was crucial to the success of this transformation, enabling the coupling to occur under mild conditions with high efficiency. The remarkable features of this chem. are its good scalability, its broad substrate scope, functional group tolerance, and the efficient modification of peptides, drugs, and natural products. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0Related Products of 67237-53-0).

3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is also used in the manufacturing of dyes such as thioindigo.Related Products of 67237-53-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Lanthanide amide-catalyzed one-pot functionalization of isatins: synthesis of spiro[cyclopropan-1,3′-oxindoles] and 2-oxoindolin-3-yl phosphates was written by Peng, Cheng;Zhai, Jiaojiao;Xue, Mingqiang;Xu, Fan. And the article was included in Organic & Biomolecular Chemistry in 2017.Related Products of 3988-77-0 This article mentions the following:

Lanthanide amide-catalyzed one-pot reaction of isatins I (R¹ = H, 7-F, 5-CH₃, etc.; R² = C₂H₅, CH₂CH=CH₂, CH₂C₆H₅), di-Et phosphite and activated alkenes R³CH=C(R⁴)R⁵ [R³ = H, C₆H₅, C(O)₂C₂H₅, etc.; R⁴ = H, CH₃, C(O)C₆H₅, etc.; R⁵ = C(O)₂CH₃, P(O)(OCH₃)₂] was developed and a series of spiro[cyclopropan-1,3′-oxindoles] II was obtained in moderate to excellent yields. The reaction is stereoselective and the two substituents at the 2 and 3-positions of the cyclopropane in the major product are in the trans configuration. A four-step mechanism involving the Pudovik reaction, Brook rearrangement, Michael addition, and intramol. nucleophilic substitution is proposed, and an umpolung strategy was used in the process. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Related Products of 3988-77-0).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Related Products of 3988-77-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The preparation of thiophenes. II. From C₅-C₇-molecules and carbon disulfide was written by Azizian, Farid;Pizey, James S.. And the article was included in Journal of Chemical Technology and Biotechnology (1979-1982) in 1980.Recommanded Product: 1795-01-3 This article mentions the following:

Alkylthiophenes were prepared in high yields by passing 7 C_5-7 alcs., 2-pentanone, or 2-hexanone and CS₂ over a promoted Cr-Al₂O₃ (Girdler G41) catalyst in the vapor phase at 500°. n-Pentane reacted with CS₂ at 600° under similar conditions to give 2-methylthiophene and thiophene in 35% and 20% yields, resp. The reaction products were identified by ¹³C NMR, IR spectroscopy, and gas-liquid chromatog., and the mechanism of the reactions is discussed with particular reference to n-pentane and 2-pentanone. The reaction of 2-pentanol with ¹³CS₂ was used to study the incorporation of the C atom of CS₂ into the thiophene ring. In the experiment, the researchers used many compounds, for example, 3-Ethylthiophene (cas: 1795-01-3Recommanded Product: 1795-01-3).

3-Ethylthiophene (cas: 1795-01-3) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Recommanded Product: 1795-01-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Hierarchical TS-1 zeolite as an efficient catalyst for oxidative desulphurization of hydrocarbon fractions was written by Serrano, D. P.;Sanz, R.;Pizarro, P.;Moreno, I.;Medina, S.. And the article was included in Applied Catalysis, B: Environmental in 2014.Related Products of 1195-14-8 This article mentions the following:

The catalytic oxidative desulphurization (ODS) of S-containing aromatic compounds has been investigated over a hierarchical TS-1 zeolite prepared from silanized protozeolitic units, characterized by having, addnl. to the zeolitic micropores, a secondary porosity within the supermicro/mesopore region. A standard TS-1 sample has been employed as reference catalyst. The influence of both the solvent (n-heptane and acetonitrile) and the oxidizing agent (hydrogen peroxide and tert-butylhydroperoxide, TBHP) was first studied using dibenzothiophene (DBT) as model substrate. In all cases, the catalytic activity exhibited by the hierarchical TS-1 was much higher than that obtained with the conventional TS-1 as a consequence of the improved accessibility caused by the presence of the secondary porosity. A very high desulphurization activity was obtained with the combination of heptane and TBHP, as solvent and oxidant, resp., leading to an almost total DBT conversion. This fact has been attributed to the fully miscibility of the oxidant solution (TBHP in decane) in the organic reaction medium. Moreover, it is noteworthy that, in these conditions, the oxidation product (sulfone) is insoluble in the reaction medium, which facilitates its removal by filtration or centrifugation. Addnl., the oxidation of different aromatic organosulfur compounds [benzothiophene (BT), 2-methylbenzothiophene (2-MBT), 2,5-dimethylthiophene (2,5-DMT) and dibenzothiophene (DBT)] was investigated using the hierarchical TS-1 catalyst. The trend in the conversion values obtained was 2,5-DMT < BT < 2-MBT < DBT. These results indicate that the oxidation conversion is determined by the nucleophilic character of the sulfur atom, and not by the mol. size of the S-containing compound, provided that the steric and diffusional limitations are overcome by the presence of the hierarchical TS-1 porosity. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Related Products of 1195-14-8).

2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is also used in the manufacturing of dyes such as thioindigo.Related Products of 1195-14-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Characterization of aroma-active compounds and perceptual interaction between esters and sulfur compounds in Xi baijiu was written by Ma, Ning;Yi, Fengping;Zhu, Jiancai. And the article was included in European Food Research and Technology in 2020.Reference of 1795-01-3 This article mentions the following:

The aroma-active compounds of three Xi baijiu samples (Xijiulan, Y1, Xijiuyinxiangguizhou, Y2 and Xijiuyinzhi, Y3) were analyzed by gas chromatog.-olfactometry (GC-O), GC-flame photometric detection (FPD) and odor activity value (OAV). The results indicated that a total of 92 aroma compounds were determined, including 16 sulfur compounds Furthermore, 2-methyl-3-furanthiol (OAV: 31-220), 3-mercapohexyl acetate (OAV: 1870), di-Me trisulfide (OAV: 333-400), 3-mercaptohexanol (OAV: 34-36), β-damascenone (OAV: 1317-1342), 2-butylfuran (OAV: 629-672), Et 3-methylbutanoate (OAV: 655-899), Et hexanoate (OAV: 687-729), and Et octanoate (OAV: 1164-1362) exhibited much higher OAVs and aroma intensities (AIs) than other compounds Finally, the perceptual interactions between five sulfur compounds and six esters were studied using Feller’s additive model in Y2. Among the 30 binary mixtures, 12 groups showed an additive effect, 4 groups exhibited a synergistic effect, and 14 groups exerted a masking effect. These data indicated that di-Me disulfide and 2-methyl-3-furanthiol had masking and additive effects on the aroma of esters. In the experiment, the researchers used many compounds, for example, 3-Ethylthiophene (cas: 1795-01-3Reference of 1795-01-3).

3-Ethylthiophene (cas: 1795-01-3) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Reference of 1795-01-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Reversible Photomodulation of Electronic Communication in a π-Conjugated Photoswitch-Fluorophore Molecular Dyad was written by Moreno, Javier;Schweighoefer, Felix;Wachtveitl, Josef;Hecht, Stefan. And the article was included in Chemistry – A European Journal in 2016.Application In Synthesis of 2-Methylbenzo[b]thiophene This article mentions the following:

The extent of electronic coupling between a boron dipyrromethene (BODIPY) fluorophore and a diarylethene (DAE) photoswitch has been modulated in a covalently linked mol. dyad by irradiation with either UV or visible light. In the open isomer, both moieties can be regarded as individual chromophores, while in the closed form the lowest electronic (S₀→S₁) transition of the dyad is slightly shifted, enabling photomodulation of its fluorescence. Transient spectroscopy confirms that the dyad behaves dramatically different in the two switching states: while in the open isomer it resembles an undisturbed BODIPY fluorophore, in the closed isomer no fluorescence occurs and instead a red-shifted DAE behavior prevails. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Application In Synthesis of 2-Methylbenzo[b]thiophene).

2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Application In Synthesis of 2-Methylbenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Evaluation of Nutritional Substances and Investigation of Antioxidant and Antimicrobial Potentials of Boerhavia diffusa with in Silico Molecular Docking was written by Kaviya, Mohandass;Balasubramanian, Balamuralikrishnan;Bharathi, Kathirvel;Malaisamy, Arunkumar;Al-Dhabi, Naif Abdullah;Mariadhas, Valan Arasu;Anand, Arumugam Vijaya;Liu, Wenchao. And the article was included in Molecules in 2022.Recommanded Product: 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene This article mentions the following:

Boerhavia diffusa L. Nyctanginaceae (B.diffusa) is a medicinal herb commonly considered as a weed. The exploration of phytochems. in different parts of B.diffusa with different solvents will create awareness, along with the suitable solvent and method for extraction of pharmaceutical compounds Hence, the present study focuses on phytochem. anal. of B.diffusa leaves, stems, and roots in various solvents with hot and cold extraction The decoctions performed well in most of the qual. and quant. tests, along with the DPPH assay. The aqueous extract showed a good result in the FRAP assay and ABTS assay. In the antimicrobial test, the B.diffusa root ethanol extract inhibited the growth of Pseudomonas aeruginosa and Staphylococcus aureus with zones of inhibition of about 8 mm and 20 mm at 200 g concentration, resp. Using a mol. docking approach, the top four ranked mols. from the crude extract of B.diffusa profiled from GC-MS spectroscopy in terms of growth inhibition of the pathogenic bacterium P.aeruginosa were selected; among them, 2-(1,2 dihydroxyethyl)-5-[[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl]oxy]oxolane-3,4-diol exhibited the min. binding score, revealing high affinity in complex. B.diffusa is highly nutritious, and the maceration and decoction extracts were similar except for the chloroform extract that was found to be weak. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Recommanded Product: 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Recommanded Product: 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Palladium-Catalyzed Intermolecular Arylcarbonylation of Unactivated Alkenes: Incorporation of Bulky Aryl Groups at Room Temperature was written by Li, Xiang;Chen, Pinhong;Liu, Guosheng. And the article was included in Angewandte Chemie, International Edition in 2018.Electric Literature of C9H8S This article mentions the following:

A palladium-catalyzed intermol. arylcarbonylation of unactivated alkenes was developed. Unsym. diaryliodonium salts (DAISs) were used as arylation reagents, the bulky aryl group (ArL) of which was exclusively incorporated into the arylcarbonylated products, which contained the ArL group and a carboxylic ester group at the α- and β-carbon position, resp., of the original terminal C-C double bond. The reaction featured excellent chemo- and regioselectivity, high functional-group tolerance, and very mild reaction conditions. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Electric Literature of C9H8S).

2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Electric Literature of C9H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Effect of surface wettability on the interfacial adhesion of a thermosetting elastomer on glass was written by Wang, Ye;Hansen, Christopher J.;Wu, Chi-Chin;Robinette, E. Jason;Peterson, Amy M.. And the article was included in RSC Advances in 2021.Product Details of 7128-64-5 This article mentions the following:

Interfacial adhesion dictates properties and performance of both composites and adhesively bonded structures. Weak adhesion at the interfaces of polymer composites leads to void formation and debonding, which adversely affect composite structural integrity and mech. performance. This work investigated the relationship between surface wettability and interfacial fracture energy with the goal of tailoring interfacial adhesion within polymer composites. A series of model functionalized surfaces was created using silane coupling agents with different organo-functionalities to alter surface wettability. Based on the anal. of interfacial fracture energy between a thermosetting elastomeric polymer network and model surfaces, interfacial adhesion was found to be pos. correlated to resin wettability. The results provide a fast and simple approach to screen different material combinations for the development of novel polymeric composites and adhesively bonded structures with tailorable adhesion. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Product Details of 7128-64-5).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Product Details of 7128-64-5

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Insights into the Reactivity of Thiophene: Heterogeneous Alkylation was written by Lucarelli, C.;Giugni, A.;Vaccari, A.. And the article was included in Topics in Catalysis in 2016.Category: benzothiophene This article mentions the following:

The importance of thiophene derivatives in the fine chem. industry lies in the use of this class of mols. as raw materials in the synthesis of drugs, fragrances and pesticides. Nowadays, the synthesis of these mols. is multistep and expensive. The gas phase alkylation of thiophene on solid acid catalysts has been deeply studied by focusing on the possibility to control the product distribution of the reaction, paying particular attention to the relative amount of the 2- and 3-alkylthiophene, kinetic and thermodn. products resp. The difficulties in changing the 2:3 isomer ratio have been justified through the comprehension of thiophene behavior on the catalyst surface, that is responsible for the complex adsorption/desorption phenomena. It has been shown that the reaction is mainly affected by the strong adsorption of thiophene on the catalytic sites, with the critical step of the reaction represented by the saturation of the catalyst surface. In the experiment, the researchers used many compounds, for example, 3-Ethylthiophene (cas: 1795-01-3Category: benzothiophene).

3-Ethylthiophene (cas: 1795-01-3) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem