Month: February 2023

Improved methods on filling reaction tubes and sample preparation of EA1110 element analyzer at CHN model was written by Wu, Bing;Cao, Xiangqian. And the article was included in Suzhou Daxue Xuebao, Ziran Kexueban in 2010.SDS of cas: 7128-64-5 This article mentions the following:

An improved method on filling reaction tubes in an EA1110 element analyzer at CHN model is stated. In a combustion tube, silver-wire, Cr₂O₃ and Co₃O₄ + Ag are filled in order, and Cu is the unique reagent in a reduction tube. Relevant actions for sample preparation are taken according to characteristics of samples. In this way, the accurate testing-results are ensured, and the average usage times of the combustion tube and the reduction tube have been increased by 24% and 59%, resp. Correspondingly, the efficiency of the element analyzer is enhanced. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5SDS of cas: 7128-64-5).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.SDS of cas: 7128-64-5

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Selective Ni-catalyzed cross-electrophile coupling of alkynes, fluoroalkyl halides and vinyl halides was written by Dai, Yubei;Wang, Fang;Zhu, Shengqing;Chu, Lingling. And the article was included in Chinese Chemical Letters in 2022.Electric Literature of C6H4S This article mentions the following:

A Ni-catalyzed three-component cross-electrophile coupling of alkynes with alkenyl halides and fluoroalkyl halides to generate fluoroalkyl-incorporated 1,3-dienes was reported. This mild and operationally simple protocol was distinguished by its broad substrate scope and excellent chemo-, regio- and stereoselectivity, offering a new and organometallic agent-free platform for the construction of fluoroalkyl-incorporated diene motifs. Preliminary mechanistic studies were conducted to probe the potential reaction pathway. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Electric Literature of C6H4S).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Electric Literature of C6H4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Fabrication of Robust Spatially Resolved Photochromic Patterns on Cellulose Papers by Covalent Printing for Anticounterfeiting Applications was written by Bretel, Guillaume;Le Grognec, Erwan;Jacquemin, Denis;Hirose, Takashi;Matsuda, Kenji;Felpin, Francois-Xavier. And the article was included in ACS Applied Polymer Materials in 2019.Application In Synthesis of 2-Methylbenzo[b]thiophene This article mentions the following:

Despite its millennial age, cellulose paper remains the preferred material for domestic and professional printings, covering applications from simple office paperwork to fiducial solutions such as bills, passports, and head letters. The creation of robust photochromic patterns on cellulose papers for anticounterfeiting applications is an important and still partially unaddressed challenge. In this contribution, we report the covalent printing of dibenzothienylethenes as photochromic compounds through a spatially controlled light-mediated thiol-X ligations. Photophys. and theor. studies provide evidence for a reversible photochromism behavior, not affected significantly by the polar environment of the cellulose matrix, and demonstrates a high fatigue resistance over 18 successive write-erase cycles. The strong coloration-discoloration switch can be easily followed by a direct naked-eye readout. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Application In Synthesis of 2-Methylbenzo[b]thiophene).

2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is also used in the manufacturing of dyes such as thioindigo.Application In Synthesis of 2-Methylbenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Influence of Glutathione Oxidation and pH on Thermal Formation of Maillard-Type Volatile Compounds was written by Tai, Chao-Ying;Ho, Chi-Tang. And the article was included in Journal of Agricultural and Food Chemistry in 1998.Safety of 3-Ethylthiophene This article mentions the following:

The Maillard-type volatile compounds obtained from the reaction of glutathione and glucose were mainly furans, carbonyl compounds, and sulfur-containing compounds including thiophenes, thiazoles, and cyclic polysulfides. Both pH 8.0 and 6.0 were favorable conditions for sulfur-containing compound formation, whereas acidic conditions were favorable for furan and derivative formation. The reaction between glutathionesulfonic acid, an oxidized form of glutathione, and glucose primarily produced furans, carbonyl compounds, pyrazines, and pyrroles. Furans dominated the products obtained from the reactions at pH 6.0 and 8.0. Pyrazines increased as the reaction pH increased. The disappearance of sulfur-containing compounds in the products of glutathionesulfonic acid and glucose reaction systems indicated glutathionesulfonic acid could not provide hydrogen sulfide for the reaction. In the experiment, the researchers used many compounds, for example, 3-Ethylthiophene (cas: 1795-01-3Safety of 3-Ethylthiophene).

3-Ethylthiophene (cas: 1795-01-3) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Safety of 3-Ethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Development of a Scalable Route for a Highly Polar Heterocyclic Aminocyclopropyl Building Block was written by Schafer, Gabriel;Ahmetovic, Muhamed;Fleischer, Tony;Abele, Stefan. And the article was included in Organic Process Research & Development in 2020.Quality Control of 1,3,2-Dioxathiolane 2,2-dioxide This article mentions the following:

A robust and scalable route toward key heterocyclic building block 1-(pyrimidin-2-yl)cyclopropan-1-amine hydrochloride from cyclopropanated starting material 1-amino-1-cyclopropanecarbonitrile hydrochloride was successfully developed. The key to success was the construction of a pyrimidine ring via cyclization from an amidine intermediate and a bench-stable 2-chloro vinamidinium hexafluorophosphate salt. The cyclization was performed under mild conditions, and the resulting 4-chloropyrimidine derivative was isolated in high yield and purity. The final hydrogenation was intensively optimized: A combination of Pd(OH)₂/C as a catalyst and NaOMe as a base at 1 bar H₂ pressure in MeOH simultaneously cleaved the Cbz group and dechlorinated the pyrimidine ring while at the same time suppressing the over-reduction of the pyrimidine ring to below 1.0%. After acidification with HCl, followed by removal of the catalyst and NaCl by filtration, the final product was isolated in high yield and purity as a bench-stable off-white solid. The overall yield of the five-step sequence was 57%. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Quality Control of 1,3,2-Dioxathiolane 2,2-dioxide).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is also used in the manufacturing of dyes such as thioindigo.Quality Control of 1,3,2-Dioxathiolane 2,2-dioxide

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Iron-catalyzed [3 + 2 + 1] annulation of 2-aminobenzimidazoles/3-aminopyrazoles and aromatic alkynes using N,N-dimethylaminoethanol as a one carbon synthon for the synthesis of pyrimido[1,2-a]benzimidazoles and pyrimido[1,2-b]indazoles was written by Qin, Zemin;Zhang, Ruiqin;Ying, Shenpeng;Ma, Yongmin. And the article was included in Organic Chemistry Frontiers in 2022.Application In Synthesis of 2-Ethynylthiophene This article mentions the following:

A simple and efficient method for the synthesis of pyrimido[1,2-a]benzimidazoles I (R = R¹ = H, Cl; R² = Ph, 1-naphthyl, 2-thienyl, etc.; R³ = H, Me, Ph, thiophen-3-yl, etc.) and pyrimido[1,2-b]indazoles II (R⁴ = H, Cl, F; R⁵ = H, Me, Br) from 2-aminobenzimidazoles/3-aminoindazoles, alkynes R²CCR³ and N,N-dimethylaminoethanol by a three-component [3+2+1] annulation catalyzed by FeCl₃ has been established, where N,N-dimethylaminoethanol was applied as a methine source. Good tolerance of the reaction makes this method applicable to construct biol. active pyrimido[1,2-a]benzimidazoles and pyrimido[1,2-b]indazoles. In addition, regioselective aryl substituted pyrimido[1,2-a]benzimidazoles were synthesized in the presence of TfOH. Replacement of alkynes with acetaldehydes gave the same pyrimido[1,2-a]benzimidazoles and pyrimido[1,2-b]indazoles. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Application In Synthesis of 2-Ethynylthiophene).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application In Synthesis of 2-Ethynylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Benzylic Arylation of 2-Methyl-5-membered Heterocycles Using TMP-Bases was written by Duez, Stephanie;Steib, Andreas K.;Knochel, Paul. And the article was included in Organic Letters in 2012.Product Details of 1195-14-8 This article mentions the following:

A new general Pd-catalyzed arylation of various 2-methyl-5-membered heterocycles is reported. This novel method requires Li-, Mg-, or Zn-TMP bases and allows selective metalation of the benzylic position. Subsequent Negishi cross-coupling provides the corresponding arylated heterocycles. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Product Details of 1195-14-8).

2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Product Details of 1195-14-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Simultaneous Immobilization of CO₂ and H₂S by Propargyl Amines under Mild Conditions: Efficient Synthesis of Thiazolidine-2-ones was written by Wu, Jiakai;He, Rongting;Cheng, Siliu;Han, Limin;Hong, Hailong;Zhu, Ning. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.Application In Synthesis of 2-Ethynylthiophene This article mentions the following:

A series of thiazolidine-2-one derivatives were synthesized by a three-component reaction of carbon dioxide, hydrogen sulfide, and propargyl amines under mild conditions. The simultaneous incorporation of carbon dioxide and hydrogen sulfide into the same organic product was realized. Moreover, a reaction mechanism was proposed based on the detailed NMR and FTIR study, which indicated that propargyl amine reacted with CO₂ first to form carbamate, followed by O/S exchange with H₂S to form thiocarbamate and the final cyclization of thiocarbamate to form thiazolidine-2-one. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Application In Synthesis of 2-Ethynylthiophene).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Application In Synthesis of 2-Ethynylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Construction of Stable Donor-Acceptor Type Covalent Organic Frameworks as Functional Platform for Effective Perovskite Solar Cell Enhancement was written by Li, Zhongping;Zhang, Zhenwei;Nie, Riming;Li, Chunzhi;Sun, Qikun;Shi, Wei;Chu, Weicun;Long, Yuyang;Li, He;Liu, Xiaoming. And the article was included in Advanced Functional Materials in 2022.Category: benzothiophene This article mentions the following:

Covalent organic frameworks (COFs) as a new class of crystalline, porous materials have attracted extensive attention in the fields of photocatalytic and photovoltaic applications. Generally, donor-acceptor (DA) structures play an important role in the charge separation efficiency of solar cells. In this study, two DA-COFs with high crystallinity, good porosity, and excellent stability are incorporated into the FAPbI₃ layer of perovskite solar cells. This addition of DA-COFs reduces the defect concentration and shallows the defect state. The donor-acceptor system in COFs also possesses strong charge-transfer pathway, which strongly prevents charge recombination to afford more efficient charge separation efficiency. The highest power-conversion efficiency of perovskite solar cells constructed with DA-COFs is 23.19% with excellent humidity stability of the solar cells. Therefore, this work provides a pathway for using DA-COFs to fabricate perovskite solar cells with higher efficiency and stability. In the experiment, the researchers used many compounds, for example, Benzo[1,2-b:3,4-b’:5,6-b”]trithiophene-2,5,8-tricarbaldehyde (cas: 2243590-42-1Category: benzothiophene).

Benzo[1,2-b:3,4-b’:5,6-b”]trithiophene-2,5,8-tricarbaldehyde (cas: 2243590-42-1) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The use of N,N-dimethylformamide-sulfonyl chloride complex for the preparation of thiophenesulfonyl chlorides was written by Sone, Tyo;Abe, Yukio;Sato, Norio;Ebina, Manabu. And the article was included in Bulletin of the Chemical Society of Japan in 1985.Safety of 4-Methylthiophene-2-sulfonyl chloride This article mentions the following:

Thiophenesulfonyl chlorides I (R = H, Me, Cl, Br, iodo, Ph, CH_iPh, CO₂Me; R¹ = SO₂Cl) were prepared in 9-79% yield by treating thiophene with a 1:1 DMF-SO₂Cl₂ complex. Some I (R¹ = HCO) were also formed. Treatment of I (R = R¹ = Me) with the complex yielded sulfonyl chloride II. In the experiment, the researchers used many compounds, for example, 4-Methylthiophene-2-sulfonyl chloride (cas: 69815-97-0Safety of 4-Methylthiophene-2-sulfonyl chloride).

4-Methylthiophene-2-sulfonyl chloride (cas: 69815-97-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Safety of 4-Methylthiophene-2-sulfonyl chloride

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem