Month: February 2023

Screening of a model for the distribution of dye in dye-encapsulated silica through the gradual etching of the outermost silica layer using hydrofluoric acid was written by Wi, Rinbok;Lee, Kyoung G.;Yoon, Sun Hong;Lee, Sang Geun;Imran, Muhammad;Kim, Do Hyun. And the article was included in Journal of Nanoscience and Nanotechnology in 2011.Synthetic Route of C26H26N2O2S This article mentions the following:

Monodispersed spherical silica particles emitting blue light were prepared by incorporating 2,5-bis(5-tert-butyl-2-benzoxazolyl)thiophene (BBOT) into a silica matrix. The morphol. and photoluminescent properties were studied to confirm the proper incorporation of BBOT into the silica matrix, using an electron microscope and a fluorescence spectrometer. Four possible models representing the distribution of the dye mols. in a dye-encapsulated silica particle were proposed. To analyze the distribution of the BBOT dye in the BBOT-encapsulated silica, the fluorescent emission intensity was measured while reducing the particle diameter by etching the outermost silica layer with hydrofluoric acid with 0-0.5 weight% concentrations The distribution of BBOT in a silica particle was studied based on the relation between the changes in particle diameter and the changes in emission intensity. The emission intensity of the BBOT-encapsulated silica particle oscillated with the decreasing particle diameter This result supported the multilayered model. Information regarding the distribution of the dye in the silica matrix will provide valuable information for understanding the formation mechanism of dye-encapsulated silica. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Synthetic Route of C26H26N2O2S).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Synthetic Route of C26H26N2O2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Addition reactions of organic carbanion equivalents via hydrazones in water was written by Wang, Yi-Zhan;Liu, Qi;Cheng, Liang;Yu, Song-Chen;Liu, Li;Li, Chao-Jun. And the article was included in Tetrahedron in 2021.Formula: C13H10OS This article mentions the following:

The addition of organometallic reagents to unsaturated bonds is one of the most powerful tools for carbon-carbon bond formations. Alkylation through organometallic reagents requires stoichiometric quantity of metal and tedious anhydrous operation in most cases. Here, “umpolung” nucleophilic additions of hydrazones to Michael acceptors, carbonyls and imines in water are reported. Under the catalysis of ruthenium(II), the addition reactions could be carried out in pure water to provide various alkylation products in moderate to good yields. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Formula: C13H10OS).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Formula: C13H10OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Transition-Metal-Free Synthesis of C3-Arylated Benzofurans from Benzothiophenes and Phenols was written by Yang, Kevin;Pulis, Alexander P.;Perry, Gregory J. P.;Procter, David J.. And the article was included in Organic Letters in 2018.COA of Formula: C8H5BrS This article mentions the following:

A transition-metal-free synthesis of benzofurans from benzothiophenes and phenols that exploits the unique reactivity of sulfoxides, is reported. Through a sequence involving an interrupted Pummerer reaction and [3,3] sigmatropic rearrangement, phenols can be combined with readily accessible yet synthetically unexplored benzothiophene S-oxides to provide C3-arylated benzofuran products. The products from this approach can undergo subsequent functionalization to gain access to a range of important benzofuran derivatives In the experiment, the researchers used many compounds, for example, 4-Bromobenzo[b]thiophene (cas: 5118-13-8COA of Formula: C8H5BrS).

4-Bromobenzo[b]thiophene (cas: 5118-13-8) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.COA of Formula: C8H5BrS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and evaluation of small libraries of triazolylmethoxy chalcones, flavanones and 2-aminopyrimidines as inhibitors of mycobacterial FAS-II and PknG was written by Anand, Namrata;Singh, Priyanka;Sharma, Anindra;Tiwari, Sameer;Singh, Vandana;Singh, Diwakar K.;Srivastava, Kishore K.;Singh, B. N.;Tripathi, Rama Pati. And the article was included in Bioorganic & Medicinal Chemistry in 2012.Related Products of 329221-38-7 This article mentions the following:

A synthetic strategy to access small libraries of triazolylmethoxy chalcones 4{1-20}, triazolylmethoxy flavanones 5{1-10} and triazolylmethoxy aminopyrimidines 6{1-17} from a common substrate 4-propargyloxy-2-hydroxy acetophenone using a set of different reactions has been developed. The chalcones and flavanones were screened against mycobacterial FAS-II pathway using a recombinant mycobacterial strain, against which the most potent compound showed ∼88% inhibition in bacterial growth and substantially induction of reporter gene activity at 100 μM concentration The triazolylmethoxy aminopyrimdines were screened against PknG of Mycobacterium tuberculosis displaying moderate to good activity (23-53% inhibition at 100 μM), comparable to the action of a standard inhibitor. In the experiment, the researchers used many compounds, for example, Ax20017 (cas: 329221-38-7Related Products of 329221-38-7).

Ax20017 (cas: 329221-38-7) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Related Products of 329221-38-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Functional derivatives of thiophene. X. Synthesis of thieno[2,3-d]pyrimidine and 2,3-polymethylene-4-oxopyrimidine derivatives was written by Shvedov, V. I.;Kharizomenova, I. A.;Grinev, A. N.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1975.Quality Control of 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid This article mentions the following:

Thienopyrimidines [I, R1 = Me, H, R2 = Me, Ph, R1R2 = (CH2)4, n = 1,2,3] were prepared in 40.6-91.2% yields by boiling II (R3 = Et, H) with the appropriate lactam 20 min in dichloroethane containing POCl3. Desulfurization of I gave 48-65.4% III [R4 = CHMeEt, CHMePh, n = 1.2.3]. In the experiment, the researchers used many compounds, for example, 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (cas: 5936-58-3Quality Control of 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid).

2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (cas: 5936-58-3) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Quality Control of 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

DDQ-Catalyzed Direct C(sp³)-H Amination of Alkylheteroarenes: Synthesis of Biheteroarenes under Aerobic and Metal-Free Conditions was written by Song, Chunlan;Dong, Xin;Yi, Hong;Chiang, Chien-Wei;Lei, Aiwen. And the article was included in ACS Catalysis in 2018.Electric Literature of C6H8S This article mentions the following:

A strategy for oxidative Csp³-H/N-H cross-coupling is presented. This reaction successfully utilizes 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and tert-Bu nitrite (TBN) as co-catalysts to construct the biomedical applicable biheteroarenes under aerobic conditions. Notably, this amination reaction is successful with a wide range of alkylheteroarenes and could be used as a functionalization tactic for pharmaceutical research and other areas. Furthermore, preliminary mechanistic studies indicate that the C-N bond formation proceeds through the nucleophilic attack of azole to the carbon cation. In the experiment, the researchers used many compounds, for example, 3-Ethylthiophene (cas: 1795-01-3Electric Literature of C6H8S).

3-Ethylthiophene (cas: 1795-01-3) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Electric Literature of C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Carboxamide-Directed Stereospecific Couplings of Chiral Tertiary Alkyl Halides with Terminal Alkynes was written by Akagawa, Hiroki;Tsuchiya, Naoki;Morinaga, Asuka;Katayama, Yu;Sumimoto, Michinori;Nishikata, Takashi. And the article was included in ACS Catalysis in 2022.HPLC of Formula: 4298-52-6 This article mentions the following:

Herein, the stereospecific Sonogashira coupling of chiral α-halocarboxamides possessing a tert-alkyl moiety R¹R²C(X)(C(O)NHR³) (R¹ = Me, Et; R² = Bu, iso-Bu, Ph, 4-methylphenyl; R³ = Ph, 2,6-diisopropylphenyl, 4-chlorophenyl, etc.; X = Br, Cl) and alkynes R⁴CCH (R⁴ = trimethylsilyl, cyclohexylmethyl, thiophen-3-yl, etc.) was reported. This reaction produces a series of chiral tert-alkylated alkynes R¹R²C(CCR⁴)(C(O)NHR³) in a stereoretentive manner. In this reaction, both the CuBr/bathophen catalyst system and carboxamide directing group are essential for achieving the high enantiospecificities of the couplings. Mechanistic studies of this reaction revealed that the alkynyl copper species is the key intermediate that coordinates to the carboxamide group of chiral α-bromocarboxamide. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6HPLC of Formula: 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.HPLC of Formula: 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Novel route for obtaining isomeric benzo[b]thiophenoindoles was written by Tsintsadze, T. G.;Khoshtariya, T. E.;Kurkovskaya, L. N.;Mirziashvili, N. T.;Sikharulidze, M. I.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2002.Application of 25288-76-0 This article mentions the following:

The authors describe a novel route for synthesis of benzo[b]thiopheno[2,3-e]- and benzo[b]thiopheno[3,2-f]indoles. As the starting compounds, the authors used the corresponding annelated isatins obtained by the Sandmeyer reaction. The authors have established that reduction of the latter to the corresponding unsubstituted benzo[b]thiophenoindoles depends both on the nature of the substituent and on the reaction conditions. In the experiment, the researchers used many compounds, for example, Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0Application of 25288-76-0).

Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is also used in the manufacturing of dyes such as thioindigo.Application of 25288-76-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

N.M.R. spectra of some substituted dibenzothiophenes was written by Campaigne, Ernest;Ashby, John. And the article was included in Journal of Heterocyclic Chemistry in 1969.SDS of cas: 25288-76-0 This article mentions the following:

In order to use the N.M.R. spectra of dibenzothiophenes to determine the position of substitution, a series of compounds was prepared, and the splitting patterns and chem. shifts evaluated will facilitate future structure determinations of dibenzothiophenes. In the experiment, the researchers used many compounds, for example, Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0SDS of cas: 25288-76-0).

Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.SDS of cas: 25288-76-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Hindering rollover failure of Li[Ni_0.5Mn_0.3Co_0.2]O₂/graphite pouch cells during long-term cycling was written by Ma, Xiaowei;Harlow, Jessie E.;Li, Jing;Ma, Lin;Hall, David S.;Buteau, Samuel;Genovese, Matthew;Cormier, Marc;Dahn, J. R.. And the article was included in Journal of the Electrochemical Society in 2019.Synthetic Route of C2H4O4S This article mentions the following:

Eventual rapid capacity loss or rollover failure of Li-ion cells during long-term cycling (> 3000 cycles in many cases) at room temperature was studied with Li[Ni_0.5Mn_0.3Co_0.2]O₂/graphite pouch cells. The effects of pos. electrode material coating, electrolyte additives, upper cutoff voltage, LiPF₆ concentration, cell rest periods, electrode thickness, graphite type and electrolyte solvent formulation were probed. Cells were tested under 1C charge and discharge with rate maps (discharges at C/20, C/2, 1C, 2C, 3C) applied every 100 cycles. The loss of high rate capability (3C) is an early warning of impending rollover failure. Electrochem. impedance spectroscopy (EIS) and studies of sym. cells made using electrodes from disassembled cells demonstrate that impedance growth at the pos. electrode and associated d.c. resistance growth is responsible for rollover failure in these cells. Ultra-high precision coulometry (UHPC) shows that cells that were charged to higher voltages, which increase the rate of electrolyte oxidation, or show higher rates of electrolyte oxidation at the same cutoff potential due to changes in electrolyte formulation, normally are more prone to eventual rollover failure. To avoid rollover and extend the cycling life of Li-ion cells, it is important to choose optimal cell chemistries, some of which are enumerated. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Synthetic Route of C2H4O4S).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Synthetic Route of C2H4O4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem