Month: February 2023

Prenatal Exposure to Emerging Plasticizers and Synthetic Antioxidants and Their Potency to Cross Human Placenta was written by Tang, Shuqin;Sun, Xiangfei;Qiao, Xinhang;Cui, Wenxuan;Yu, Feixiang;Zeng, Xiaowen;Covaci, Adrian;Chen, Da. And the article was included in Environmental Science & Technology in 2022.Category: benzothiophene This article mentions the following:

Gestational exposure to environmental chems. and subsequent permeation through the placental barrier represents potential health risks to both pregnant women and their fetuses. In the present study, we explored prenatal exposure to a suite of 46 emerging plasticizers and synthetic antioxidants (including five transformation products of 2,6-di-tert-butyl-4-hydroxytoluene, BHT) and their potency to cross human placenta based on a total of 109 maternal and cord serum pairs. Most of these chems. have rarely or never been investigated for prenatal exposure and associated health risks. Eleven of them exhibited detection frequency greater than 50% in maternal blood, including di-Bu fumarate (DBF), 2,6-di-tert-butylphenol (2,4-DtBP), 1,3-diphenylguanidine (DPG), methyl-2-(benzoyl)benzoate (MBB), tri-Et citrate (TEC), BHT, and its five metabolites, with a median concentration from 0.05 to 3.1 ng/mL. The transplacental transfer efficiency (TTE) was determined for selected chems. with valid measurements in more than 10 maternal/cord blood pairs, and the mean TTEs exhibited a large variation (i.e., 0.29-2.14) between chems. The determined TTEs for some of the target chems. were comparable to the predicted values by our previously proposed models developed from mol. descriptors, indicating that their transplacental transfer potency could be largely affected by physicochem. properties and mol. structures. However, addnl. biol. and physiol. factors may influence the potency of environmental chems. to cross human placenta. Overall, our study findings raise concern on human exposure to an increasing list of plastic additives during critical life stages (e.g., pregnancy) and potential health risks. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Category: benzothiophene).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Furan Synthesis via Triplet Sensitization of Acceptor/Acceptor Diazoalkanes was written by Zhu, Siqi;Li, Fang;Empel, Claire;Jana, Sripati;Pei, Chao;Koenigs, Rene M.. And the article was included in Advanced Synthesis & Catalysis in 2022.COA of Formula: C6H4S This article mentions the following:

Herein, authors report on the photocatalytic reaction of acceptor/acceptor diazoalkanes with terminal alkynes. Exptl. and computational studies suggest the formation of a key triplet carbene intermediate that underwent an addition reaction to the alkyne followed by cyclization to give furan heterocycles (31 to 90% yield). This reaction was studied with a broad range of alkynes and acceptor/acceptor diazoalkanes and now provides access to furans under mild reaction conditions. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0COA of Formula: C6H4S).

3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.COA of Formula: C6H4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Product class 6: dibenzothiophenes was written by Andrews, M. D.. And the article was included in Science of Synthesis in 2001.Application In Synthesis of Dibenzo[b,d]thiophen-3-amine This article mentions the following:

Methods for preparing dibenzothiophenes are reviewed including cyclization, ring transformation, aromatization and substituent modifications. In the experiment, the researchers used many compounds, for example, Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0Application In Synthesis of Dibenzo[b,d]thiophen-3-amine).

Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Application In Synthesis of Dibenzo[b,d]thiophen-3-amine

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis of (Deoxy)difluoromethylated Phosphines by Reaction of R₂P(O)H with TMSCF₃ and Their Application in Cu(I) Clusters in Sonogashira Coupling was written by Yang, Xiaogang;Lu, Dong;Guan, Wenjian;Yin, Shuang-Feng;Kambe, Nobuaki;Qiu, Renhua. And the article was included in Journal of Organic Chemistry in 2022.Reference of 4298-52-6 This article mentions the following:

R₂PCF₂H ligands and their R₂P(O)CF₂H precursors were synthesized from R₂P(O)H with TMSCF₃ by simply modulating the H₂O concentration via deoxydifluoromethylation and difluoromethylation. The air sensitive R₂PCF₂H phosphines can be stabilized in Cu(I) clusters as ligands. Within these Cu(I) clusters, the Sonogashira cross-coupling reaction can proceed fast and efficiently using terminal alkynes and aryl iodides within 15 min at room temperature under air to give a variety of diaryl(alkyl)acetylenes in good yields (49 examples, yields of ≤99%). Six of the internal alkynes present in drug precursors can be obtained using this protocol in good yields. The mechanism is proposed from control experiments In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Reference of 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Reference of 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Properties and deep hydrodesulfurization of MIP naphtha was written by Pang, Hong;Zhao, Leping;You, Bailing;Duan, Weiyu;Liu, Jihua. And the article was included in Lianyou Jishu Yu Gongcheng in 2006.Safety of 3-Ethylthiophene This article mentions the following:

The variations of sulfur and olefin in FCC naphtha in typical Chinese refineries are studied and MIP naphtha and conventional FCC naphtha are compared in respect of properties. When the MIP naphtha with 31.0 v% olefin is treated by selective hydrodesulfurization process-OCT-M developed by SINOPEC Fushun Research Institute of Petroleum and Petrochems., the sulfur is reduced to less than 50 ppm from 664 ppm. Octane loss is only 0.7-1.7%. The process provides a flexible and economic solution for the production of cleaner gasoline of Euro IV specifications from MIP naphtha in refineries. In the experiment, the researchers used many compounds, for example, 3-Ethylthiophene (cas: 1795-01-3Safety of 3-Ethylthiophene).

3-Ethylthiophene (cas: 1795-01-3) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Safety of 3-Ethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Effect of electrolyte additives on the performance of high nickel Li-ion battery was written by Zhou, Mi;Wang, Xi-min;Yuan, Yin-nan;Cao, Zhang;Zheng, Hong-he. And the article was included in Dianchi in 2022.Related Products of 1072-53-3 This article mentions the following:

Application effects of electrolyte additives, including vinylene carbonate (VC), 1,3-propanesultone (PS), fluoroethylene carbonate (FEC), ethylene sulfate (DTD) in high nickel (Ni) [n (Ni) ≥80%] cathode material Li-ion battery were studied. The electrochem. performance, syngas and morphol. of anode interface of LiNi_0.8Co_0.1Mn_0.1O₂ (NCM811) |SiO_x/graphite pouch battery and Li|SiO_x/graphite button cell were analyzed. Except for PS, the other additives did not influence the initial capacity of SiOx/graphite electrode, VC and PS contributed to an increase of the interface impedance of SiO_x/graphite. For pouch battery, VC, PS and FEC could decrease the gas evolution, but the gas production of DTD increased and the main gases were alkanes. The battery using FEC owned the best room temperature and low temperature rate capability, the discharge capacity at 25°C and -20°C was 92.0% and 68.2% compared with nominal capacity at 0.5 C, 75.2% and 21.5% at 2.0 C. After stored at 60°C for 14 d, the capacity recovery rate and retention rate were 63.3% and 48.5% for the battery using FEC, resp., the voltage drop was 2.7%, the battery using DTD was 72.4%, 63.6% and 1.3%, resp. The battery using DTD and FEC had the best high temperature and room temperature cycle performance, resp. SEM anal. showed that in the battery using FEC, the anode interface of SiO_x/graphite after high temperature cycle was covered with more coating materials, thick film formation and rough surface. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Related Products of 1072-53-3).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Related Products of 1072-53-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A novel type of radical-addition-induced β-fragmentation and ensuing remote functionalization was written by Li, Xin;Shui, Yang;Shen, Pingkang;Wang, Yi-Peng;Zhang, Chi;Feng, Chao. And the article was included in Chem in 2022.Computed Properties of C6H4S This article mentions the following:

Herein, authors report a strategically novel synthetic protocol for the efficient construction of α-trifluoromethyl-β-amino ketone and α-sulfonyl-β-amino ketone derivatives 4-Isoxazoline is introduced, for the first time, as a class of effective nucleophilic SOMOphile (SOMO, single occupied MO) that readily reacts with electrophilic open-shell species such as trifluoromethyl radical and sulfonyl radical through a cascade of the homolytic addition/β-fragmentation manifold. The underlying polar effect is ascribed as the dominant factor that guarantees the cascade process both in high reaction efficiency and regioselectivity. This protocol is characterized by its mild reaction conditions and broad substrate scope, whereas the ease of acquiring enantiopure α-polyfluoroalkyl-β-amino ketone derivatives with readily accessed chiral 4-isoxazolines adds extra merit to this reaction. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Computed Properties of C6H4S).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Computed Properties of C6H4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem