Month: February 2023

Direct Carboxylation of Electron-Rich Heteroarenes Promoted by LiO-tBu with CsF and [18]Crown-6 was written by Shigeno, Masanori;Hanasaka, Kazuya;Sasaki, Keita;Nozawa-Kumada, Kanako;Kondo, Yoshinori. And the article was included in Chemistry – A European Journal in 2019.Computed Properties of C11H10O3S This article mentions the following:

The combination of LiO-tBu, CsF, and [18]crown-6 efficiently promoting the direct C-H carboxylation of electron-rich heteroarenes (benzothiophene, thiophene, benzofuran, and furan derivatives) I (R = Me, CN, Br, MeO, Cl, F; R¹ = H, CH₃, Br) and II (R² = Br, C₆H₅, C(O)C₆H₅, etc.; R³ = H; R²R³ = CH=CH-CH=CH; X = O, S) has been demonstrated. A variety of functional groups, including Me, methoxy, halo, cyano, amide, and keto moieties, is compatible with this system. The reaction proceeds via the formation of a tert-Bu carbonate species. In the experiment, the researchers used many compounds, for example, Methyl 5-methoxybenzo[b]thiophene-2-carboxylate (cas: 19492-99-0Computed Properties of C11H10O3S).

Methyl 5-methoxybenzo[b]thiophene-2-carboxylate (cas: 19492-99-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Computed Properties of C11H10O3S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Determination of five fluorescent whitening agents in foam plastic tableware by high performance liquid chromatography tandem mass spectrometry was written by Du, Zhi-feng;Xian, Yan-ping;Liu, Fu-jian;Huang, Jin-feng;Wu, Yu-luan;Guo, Xin-dong;Wang, Yong-hua;Luo, Dong-hui. And the article was included in Xiandai Shipin Keji in 2013.Safety of 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene This article mentions the following:

A simple and sensitive method has been developed for the simultaneous determination of five fluorescent whitening agents (FWA135, FWA184, FWA367, FWA368 and FWA393) in foam plastic tableware using high performance liquid chromatog. tandem mass spectrometry (HPLC-MS/MS). The samples were extracted with trichloromethane, and the polymer in the extracts were precipitated by adding methanol. The separation of five FWAs was carried out on a Phenomenex kinetex C₁₈ column (2.1 mm × 100 mm, 2.6 μm) by gradient elution with 0.1% formic acid methanol and 0.1% formic acid as mobile phase. Electrospray ionization mass was operated in the pos. mode (ESI⁺) using multiple reaction monitoring (MRM) for the qual. and quant. anal. of five FWAby retention time and ion ratio. The result indicated that the linear correlation coefficients (r > 0.995) of five FWAs were obtained with the linear relationship between 0.5 to 50 μg/L. The limits of detection (ILOD, S/N = 3) were ranged from 0.1 μg/L to 0.5 μg/L, and the limits of qualification of the method (MLOQ, S/N = 10) were varied from 0.4 μg/kg to 2.0 μg/kg. The recoveries of five FWAs from spiked samples at the spiking levels of 2 μg/kg, 8 μg/kg and 200 μg/kg were between 86.4% and 98.4% with RSD (n = 6) less than 3.9% to 8.1%. The method was simple and precise for the determination of five FWAs in foam plastic tableware. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Safety of 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Safety of 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Digital Light Processing of Highly Filled Polymer Composites with Interface-Mediated Mechanical Properties was written by Wang, Ye;Delarue, Antoine P.;McAninch, Ian M.;Hansen, Christopher J.;Robinette, E. Jason;Peterson, Amy M.. And the article was included in ACS Applied Polymer Materials in 2022.Recommanded Product: 7128-64-5 This article mentions the following:

Digital light processing (DLP) is a popular method of additive manufacturing of thermosetting polymer composites with high resolution While DLP of composite systems has been demonstrated, only a few studies comment on the role of interfacial interactions on resulting mech. properties. In this work, high volume fraction (50 volume %) glass microsphere-reinforced composites were fabricated via DLP. The effects of surface chem. and interfacial interactions on the mech. and thermal properties of additively manufactured composites were investigated. Interfacial interactions between the urethane acrylate-based resin system and glass microspheres were found to dictate the overall performance of the composites. Greater resin-glass wettability led to simultaneous and anomalous increases in stiffness, toughness, and strength. Interestingly, composites where glass was functionalized to covalently bond with the resin phase only showed moderate improvements in mech. properties as compared to systems with high resin-glass wettability. Finally, complex structures with fine details were printed to demonstrate printability. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Recommanded Product: 7128-64-5).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Recommanded Product: 7128-64-5

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Labeling of unnatural amino acids with technetium-99m and tissue distribution of the labeled products in mice was written by Tamemasa, Osamu;Goto, Rensuke;Takeda, Atsushi. And the article was included in Radioisotopes in 1981.HPLC of Formula: 32595-59-8 This article mentions the following:

^99mTc-labeled unnatural amino acids were prepared by conventional methods and their distribution in mice organs after i.v. injection was determined Most of the labeled amino acids were found in the kidney, whereas only small amounts in the pancreas. ^99mTc-labeled 4-azaleucine and -azaserine showed the highest distribution in the liver (19.3 and 17.1% dose/g wet weight, resp.). A low distribution in the stomach was shown only by a few of the labeled amino acids. In the experiment, the researchers used many compounds, for example, 2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid (cas: 32595-59-8HPLC of Formula: 32595-59-8).

2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid (cas: 32595-59-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is also used in the manufacturing of dyes such as thioindigo.HPLC of Formula: 32595-59-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Ternary Electrolyte Additive Mixtures for Li-Ion Cells that Promote Long Lifetime and Less Reactivity with Charged Electrodes at Elevated Temperatures was written by Ma, Lin;Xia, Jian;Dahn, J. R.. And the article was included in Journal of the Electrochemical Society in 2015.Formula: C2H4O4S This article mentions the following:

Li[Ni_1/3Mn_1/3Co_1/3]O₂ (NMC111)/graphite and Li[Ni_0.42Mn_0.42Co_0.16]O₂ (NMC442)/graphite pouch cells demonstrate superb performance when ternary blends of electrolyte additives are added to the cells. These ternary blends contain one of vinylene carbonate (VC) or prop-1-ene-1,3-sultone (PES) plus a S containing mol. and tris(trimethylsilyl) phosphite (TTSPi). Here, the excellent charge-discharge capacity retention of cells containing these ternary blends of additives is demonstrated at both 45° and 55°C by comparison to cells with only VC or PES additives alone. The impact of a number of S- and phosphorous-containing electrolyte additives on the reactivity of charged electrode materials with electrolyte at elevated temperatures was studied using accelerating rate calorimetry (ARC). The electrolyte additives, methylene methanedisulfonate (MMDS) and TTSPi, dramatically reduce the reactivity between lithiated (charged) graphite and electrolyte. The ternary electrolyte blends of VC + MMDS + TTSPi and PES + MMDS + TTSPi show no reactivity between charged graphite and electrolyte to >200°. By contrast, electrolytes with no additives or with PES alone show significant reactivity with lithiated graphite <200°. NMC/graphite cells with VC + MMDS + TTSPi or PES + MMDS + TTPSi additives will demonstrate long life and excellent safety. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Formula: C2H4O4S).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Formula: C2H4O4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Complementarity between fluorescence and reflection in photoluminescent cholesteric liquid crystal devices was written by Kim, Jang-Kyum;Joo, Suk-Hwan;Song, Jang-Kun. And the article was included in Optics Express in 2013.SDS of cas: 7128-64-5 This article mentions the following:

The combination of photoluminescence (PL) and cholesteric liquid crystal (CLC) provides interesting complementary features for an optimized display application. Distortion of the Bragg lattice of CLCs decreases selective reflection but increases fluorescence intensity; recovery of a uniform lattice in turn results in increased reflection and decreased fluorescence. This complementary relationship between the fluorescence and the Bragg reflection gives rise to self-compensations for color shifts due to either dynamic slow response of CLC helix or mismatch of oblique incidence of light with respect to the helical axis. These color shifts have long been intrinsic unsolved limitations of conventional CLC devices. Thus, the complementary coupling between the fluorescence and the CLC Bragg reflections plays an important role in improving the color performance and the quality of moving images. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5SDS of cas: 7128-64-5).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.SDS of cas: 7128-64-5

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Oxidative diversification of amino acids and peptides by small-molecule iron catalysis was written by Osberger, Thomas J.;Rogness, Donald C.;Kohrt, Jeffrey T.;Stepan, Antonia F.;White, M. Christina. And the article was included in Nature (London, United Kingdom) in 2016.Computed Properties of C9H8S This article mentions the following:

Secondary metabolites synthesized by non-ribosomal peptide synthetases display diverse and complex topologies and possess a range of biol. activities. Much of this diversity derives from a synthetic strategy that entails pre- and post-assembly oxidation of both the chiral amino acid building blocks and the assembled peptide scaffolds. The vancomycin biosynthetic pathway is an excellent example of the range of oxidative transformations that can be performed by the iron-containing enzymes involved in its biosynthesis. However, because of the challenges associated with using such oxidative enzymes to carry out chem. transformations in vitro, chem. syntheses guided by these principles have not been fully realized in the laboratory Here we report that two small-mol. iron catalysts are capable of facilitating the targeted C-H oxidative modification of amino acids and peptides with preservation of α-center chirality. Oxidation of proline to 5-hydroxyproline furnishes a versatile intermediate that can be transformed to rigid arylated derivatives or flexible linear carboxylic acids, alcs., olefins and amines in both monomer and peptide settings. The value of this C-H oxidation strategy is demonstrated in its capacity for generating diversity: four ‘chiral pool’ amino acids are transformed to twenty-one chiral unnatural amino acids representing seven distinct functional group arrays; late-stage C-H functionalizations of a single proline-containing tripeptide furnish eight tripeptides, each having different unnatural amino acids. Addnl., a macrocyclic peptide containing a proline turn element is transformed via late-stage C-H oxidation to one containing a linear unnatural amino acid. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Computed Properties of C9H8S).

2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Computed Properties of C9H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Influence of π-Endcaps on the Performance of Functionalized Quinolines for p-Channel OFETs was written by Anjali, Anshika;Imran, Predhanekar Mohamed;Bhuvanesh, Nattamai S. P.;Nagarajan, Samuthira. And the article was included in Macromolecular Rapid Communications in 2022.Recommanded Product: 2-Ethynylthiophene This article mentions the following:

This study investigates the influence of aryl and ethynyl linkers as well the effect of various pi-end-groups on the performance of the quinoline-based organic field-effect transistors. A series of new functionalized quinolines with D-π-A-π-D and A-π-A-π-A architectures are designed and synthesized via the Sonagashira cross-coupling reaction. All the new compounds are well characterized and their photophys. properties are studied. The bottom gate-top contact-organic field-effect transistors devices are fabricated using the spin-coating technique. By employing the pre and post-annealing technique, films with uniform surface coverage are obtained. The variation in the end-groups results in versatile packing arrangements which determine their good charge transport properties. The p-channel transistor behavior is observed for all the new compounds Among the mols. studied, methoxyphenyl and thiophen-2-yl terminal functionalized with D-π-A-π-D architecture exhibit the higher p-channel transistor characteristics with hole mobilities of 1.39 and 1.33 cm² V^-1 s^-1, resp. The good charge carrier mobilities are supported by an electron-donating methoxy group and thiophene as the end-groups with high highest occupied MOs (HOMO) and lowest unoccupied MOs (LUMO) levels, extensive π-conjugation, and better self-assembly. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Recommanded Product: 2-Ethynylthiophene).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Recommanded Product: 2-Ethynylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Room-Temperature Gold-Catalysed Arylation of Heteroarenes: Complementarity to Palladium Catalysis was written by Cresswell, Alexander J.;Lloyd-Jones, Guy C.. And the article was included in Chemistry – A European Journal in 2016.Product Details of 1195-14-8 This article mentions the following:

Tailoring of the pre-catalyst, the oxidant and the arylsilane enables the first room-temperature, gold-catalyzed, innate C-H arylation of heteroarenes. Regioselectivity is consistently high and, in some cases, distinct from that reported with palladium catalysis. Tolerance to halides and boronic esters, in both the heteroarene and silane partners, provides orthogonality to Suzuki-Miyaura coupling. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Product Details of 1195-14-8).

2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Product Details of 1195-14-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Evaluation of on-line pyrolysis two-dimensional gas chromatography time-of-flight mass spectrometry (Py-GC × GC-ToFMS) on whole sediments from a Mediterranean sapropel sequence was written by Payeur, Amy L.;Meyers, Philip A.;Sacks, Richard D.. And the article was included in Organic Geochemistry in 2011.Quality Control of 3-Ethylthiophene This article mentions the following:

Anal. of the mol. composition of the organic matter (OM) from whole sediment samples can avoid anal. bias that might result from isolation of components from the sediment matrix, but has its own anal. challenges. We evaluated the use of GC × GC-ToFMS to analyze the pyrolysis products of six whole sediment samples obtained from above, within and below a 1 million year old OM-rich Mediterranean sapropel layer. We found differences in pyrolysis products <n-C₂₂ between the OM-rich sapropel samples and the OM-poor background marls. The presence of alkyl pyrroles, probably derived from chlorophyll, in pyrolyzates of the sapropels but not in those of the marls suggests that higher marine productivity and greater OM preservation accompanied deposition of the sapropels. Detection of tetra-Me benzenes considered to be pyrolysis products of isorenieratene in the sapropel samples is evidence that nitrogen-fixing green sulfur bacteria contributed to the high productivity. Greater abundances of shorter chain aliphatic hydrocarbons, pyrroles, furans and alkyl aromatics in the pyrolyzates of sapropel samples relative to the marls confirm better preservation of marine OM in the sapropels. In addition, the presence of greater amounts of thiophenes in the sapropels than in the marls is consistent with the existence of euxinic conditions during sapropel deposition. The combination of whole sediment pyrolysis and GC × GC-ToFMS is promising, but the procedure requires careful selection of its multiple anal. variables, particularly the pyrolysis temperature and the operational features of the GC columns. In the experiment, the researchers used many compounds, for example, 3-Ethylthiophene (cas: 1795-01-3Quality Control of 3-Ethylthiophene).

3-Ethylthiophene (cas: 1795-01-3) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Quality Control of 3-Ethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem