With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20699-85-8,Methyl 5-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.
To a mixture of compound 133 (508 mg, 2.106 mmol) and compound 61 (300 mg, 1.404 mmol) in DMF (7.021 mL) was added EDC (567 mg, 2.81 mmol) and DMAP (429 mg, 3.51 mmol) at rt. After stirring for 3 h, the reaction was diluted with EtOAc and then washed with water, sat?d aq. NaHC03 and brine. The organic layer was dried over MgS04, filtered and concentrated to obtain compound 138, which was used in the next step without purification (0.6 g, 100% yield). LCMS = 8.36 min (15 min method). Mass observed (EST): 429.0 (M-H).
20699-85-8, The synthetic route of 20699-85-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; IMMUNOGEN, INC.; MILLER, Michael, Louis; SHIZUKA, Manami; CHARI, Ravi, V.J.; (312 pag.)WO2019/133652; (2019); A1;,
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