On June 16, 2016, Jones, Michael L.; Lilly, John C.; Ankala, Sudha V.; Singleton, Scott F. published a patent.Formula: C9H5ClOS The title of the patent was Preparation of quinazolinones, indazoles and other heterocyclic compounds as SOS inhibitors and antibiotic potentiators. And the patent contained the following:
The invention relates to preparation of quinazolinones of formula I, indazoles of formula II , wherein all the variables are as defined in the disclosure, and other heterocyclic compounds as SOS inhibitors and their use as antibiotics and as antibiotic potentiators. The example compound III was prepared by multistep synthesis according to the procedure shown and was tested for its antibacterial and SOS response-inhibiting activity (data disclosed). The compounds may act as colistin potentiators and SOS inhibitors. The experimental process involved the reaction of 5-Chlorobenzo[b]thiophene-3-carbaldehyde(cas: 16296-68-7).Formula: C9H5ClOS
The Article related to quinazolinone indazole preparation sos inhibitor antibiotic potentiator combination chemotherapy, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C9H5ClOS
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem