Category: 1468-83-3

Miao, Pannan published the artcileVisible-light induced metal-free cascade Wittig/hydroalkylation reactions, Category: benzothiophene, the main research area is carbonyl phosphonium ylide thiol tandem Wittig hydroakylation green chem.

Through a relay olefination and radical addition process, visible light induced cascade Wittig/hydroalkylation reactions were developed. This metal-free radical approach featured mild conditions, robustness and excellent functionality compatibility. It allowed access to saturated C3 homologation products directly from aldehydes or ketones. The synthetic utility of this method was demonstrated by a two-step synthesis of indolizidine 209D.

Green Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Category: benzothiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Li, Chengxi published the artcileEngaging aldehydes in CuH-catalyzed reductive coupling reactions: stereoselective allylation from 1,3-diene pronucleophiles, Computed Properties of 1468-83-3, the main research area is copper hydride catalyst stereoselective allylation aldehyde diene mol modeling; aldehydes; allylic compounds; copper; dienes; reductive coupling.

Recently, CuH-catalyzed reductive coupling processes involving carbonyl compounds and imines have become attractive alternatives to traditional methods for stereoselective addition because of their ability to use readily accessible and stable olefins as surrogates for organometallic nucleophiles. However, the inability to use aldehydes, which usually reduce too rapidly in the presence of copper hydride complexes to be viable substrates, has been a major limitation. Shown here is that by exploiting relative concentration effects through kinetic control, this intrinsic reactivity can be inverted and the reductive coupling of 1,3-dienes with aldehydes achieved. Using this method, both aromatic and aliphatic aldehydes can be transformed into synthetically valuable homoallylic alcs. with high levels of diastereo- and enantioselectivities, and in the presence of many useful functional groups. Furthermore, using a combination of theor. (DFT) and exptl. methods, important mechanistic features of this reaction related to stereo- and chemoselectivities were uncovered. Recently, CuH-catalyzed reductive coupling processes involving carbonyl compounds and imines has become an attractive alternative to traditional methods for stereoselective addition to carbonyls due to the ability to use readily accessible and stable olefin-derived pronucleophiles as surrogates for organometallic reagents. However, the inability to use aldehydes, which traditionally reduce too rapidly in the presence of copper hydride complexes to be viable substrates, has been a major limitation. We show that by exploiting relative concentration effects through slow addition, we can invert this intrinsic reactivity and achieve the reductive coupling of 1,3-dienes with aldehydes. Using this method, both aromatic and aliphatic aldehydes can be transformed to valuable products with high levels of diastereo- and enantioselectivity and in the presence of many useful functional groups. Furthermore, using a combination of theor. (DFT) and exptl. methods, important mechanistic features of this reaction related to stereo- and chemoselectivity were uncovered.

Angewandte Chemie, International Edition published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Computed Properties of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Zhang, Haiyan published the artcileCobalt-catalyzed diastereo- and enantioselective allyl addition to aldehydes and α-ketoesters through allylic C-H functionalization, SDS of cas: 1468-83-3, the main research area is homoallylic alc preparation diastereo enantioselective; aldehyde ketoester allylbenzene cobalt catalyst allyl addition.

Development of catalytic generation of allyl-metal complexes through allylic C-H cleavage of alkenes without prefunctionalization followed by site- and stereoselective carbon-carbon bond formation is of great importance in organic synthesis, providing a straightforward and step-economical approach to introduce a versatile allyl group into organic mols. Although significant advances have been achieved in enantioselective transformations of electrophilic allyl-metal complexes and allyl radicals, enantioselective reactions of nucleophilic allyl-metal intermediates furnished through allylic C-H cleavage remain undeveloped. Herein, authors identify a multi-tasking chiral catalyst derived from a com. available phosphine ligand and cobalt salt that precisely controls the chemoselective formation of the allyl-cobalt complex and the site- and stereoselective addition to carbonyls, delivering a broad scope of homoallylic alcs. with high yield and stereoselectivity. This work may establish a platform for the development of enantioselective transformations of nucleophilic organometallic complexes generated from catalytic C-H functionalization.

Cell Reports Physical Science published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, SDS of cas: 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Rastogi, Gaurav K. published the artcileDiastereoselective sp3-C-H Functionalization of Arylmethyl Ketones and Transformation of E- to Z-Products Through Photocatalysis, Synthetic Route of 1468-83-3, the main research area is enedione diastereoselective synthesis arylmethyl ketone photocatalyzed transformation.

We have developed an efficient metal-free route for the synthesis of 1,4-enedione derivatives under microwave irradiation by reacting easily available arylmethylketones with DMSO or di-Ph sulfoxide in the presence of TBAI and persulfate. The reaction is very clean and completes within very short time. All the reagents and catalysts are cheap and environmentally benign. In addition, the E-isomer of the products can easily be transformed into the Z-isomer by using eosin Y photocatalyst under the irradiation of white CFL.

European Journal of Organic Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Synthetic Route of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Nori, Divakara Lsomayajulu published the artcileOptimized synthesis of active 5-benzylidine-1,3-thiazolidine- 2,4-dione derivatives, Recommanded Product: 3-Acetylthiophene, the main research area is benzylidene thiazolidinedione preparation; dioxothiazolidinylidenylmethyl benzaldehyde acetophenone condensation.

The active substrates 5-benzylidine-1,3-thiazolidine-2,4-dione derivatives which are a class of α- glucosidase inhibitors was prepared from 4-((Z)-(2,4-dioxothiazolidin-5-ylidene)methyl)benzaldehyde with aromatic/ hetero aromatic ketones in presence of potassium hydroxide with ethanol as solvent. In order to improve the yields the synthesis of 5-benzylidine-1,3-thiazolidine-2,4-dione derivatives were optimized by screening different bases and solvents. Finally better conditions for preparation of these derivatives were established by Quality by design. The 5-benzylidine-1,3-thiazolidine-2,4-dione derivatives were prepared with excellent yield.

Journal of Applicable Chemistry (Lumami, India) published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Stumpf, Andreas published the artcileSynthesis of 3-Aryl-Substituted 4-Aminopyrazoles from Acetophenones, Synthetic Route of 1468-83-3, the main research area is aryl substituted aminopyrazole preparation; acetophenone oximation condensation.

A synthetic methodol. for a protecting-group-free formation of 3-aryl-substituted 4-aminopyrazoles I [R = 4-MeOC6H4, 3-pyridyl, 3-thienyl, etc.] from acetophenones via a telescoped oximation and hydrazine condensation of 1,3-ketoaldehydes to generate nitrosopyrazoles, and copper-catalyzed NaBH4 reduction of the nitroso group, was demonstrated. The synthesis tolerated a broad scope of substrates with a variety of substituents on the Ph ring to afford the desired products.

Synthesis published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Synthetic Route of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Ni, Penghui published the artcileA Three-Component Strategy for Benzoselenophene Synthesis under Metal-Free Conditions Using Selenium Powder, Recommanded Product: 3-Acetylthiophene, the main research area is three component indole acetophenone selenium; benzoselenophene preparation.

An efficient three-component benzoselenophenes formation has been developed from substituted indoles, acetophenones, and selenium powder under metal-free conditions. 2-Aryl indoles played an important role to promote benzoselenophene formation from acetophenone derivatives and selenium powder. One C-C and two C-Se bonds were selectively formed to provide 40 new benzoselenophenes in good yields.

Organic Letters published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Li, Wei published the artcileDesign of Ru(II)-NHC-Diamine Precatalysts Directed by Ligand Cooperation: Applications and Mechanistic Investigations for Asymmetric Hydrogenation, Name: 3-Acetylthiophene, the main research area is ruthenium heterocyclic carbene complex diamine precatalyst preparation; isocoumarin benzothiophene dioxide ketone enantioselective hydrogenation.

A modular synthesis of Ru(II)-NHC-diamine complexes from readily available chiral N-heterocyclic carbenes (NHCs) and chiral diamines is disclosed for the first time. The well-defined Ru(II)-NHC-diamine complexes show unique structure and coordination chem. including an unusual tridentate coordination effect of 1,2-diphenylethylenediamine. The isolated air-and moisture-stable Ru(II)-NHC-diamine complexes act as versatile precatalysts for the asym. hydrogenation of isocoumarins, benzothiophene 1,1-dioxides, and ketones. Moreover, based on the identification of reaction intermediates by stoichiometric reactions and NMR experiments, together with the DFT calculations, a possible catalytic cycle was proposed.

Journal of the American Chemical Society published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Name: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Xiao, Zihui published the artcileElectrochemical reduction of functionalized carbonyl compounds: enhanced reactivity over tailored nanoporous gold, Application In Synthesis of 1468-83-3, the main research area is reusable nanoporous gold catalyst preparation pore size carbonyl reduction; carbonyl compound diphenylsilane gold nanocatalyst electrochem reduction chemoselective; alc preparation.

The effect of the pore size of nanoporous gold (NPG) on electrochem. reduction of functionalized carbonyl compounds was investigated. NPG with a pore size of ∼30 nm significantly enhanced the reactivity with high chemoselectivity at a low-potential. Typically, p-nitrobenzaldehyde reduction demonstrated a high turnover frequency (TOF) up to 232000 h-1.

Nanoscale published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Application In Synthesis of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Ibrahim, Jessica Juweriah published the artcileEfficient Transfer Hydrogenation of Ketones Catalyzed by a Phosphine-Free Cobalt-NHC Complex, Synthetic Route of 1468-83-3, the main research area is ketone transfer hydrogenation cobalt NHC complex catalyst.

A simple phosphine-free cobalt-NHC pincer complex was synthesized and used for the transfer hydrogenation of ketones with 2-propanol as hydrogen donor. A broad range of ketones varying from aromatic, aliphatic and heterocyclic were effectively reduced to their corresponding alcs. in moderate to excellent yields with good tolerance of functional groups.

European Journal of Organic Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Synthetic Route of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem