Category: 1468-83-3

Zhang, Bing published the artcileRhodium-Catalyzed Regiodivergent Synthesis of Alkylboronates via Deoxygenative Hydroboration of Aryl Ketones: Mechanism and Origin of Selectivities, Recommanded Product: 3-Acetylthiophene, the main research area is rhodium catalyzed regiodivergent regioselective hydroboration aryl ketone; branched alkylboronate triboronate preparation; mol structure calculation rhodium catalyzed regioselective hydroboration aryl ketone.

Here, authors report an efficient rhodium-catalyzed deoxygenative borylation of ketones to synthesize alkylboronates, in which the regioselectivity can be switched by the choice of the ligand. The linear alkylboronates were obtained exclusively in the presence of P(nBu)3, and PPh2Me favored the formation of branched alkylboronates. The protocol also allows access to 1,1,2-triboronates from the readily available ketones. Mechanistic studies suggest that this Rh-catalyzed deoxygenative borylation of ketones goes through an alkene intermediate, which undergoes regiodivergent hydroboration to afford linear and branched alkylboronates. The different steric effects of PPh2Me and P(nBu)3 were responsible for product selectivity by d. functional theory calculations The alkene intermediate can alternatively undergo sequential dehydrogenative borylation and hydroboration to deliver the triboronates.

ACS Catalysis published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Wu, Xin-Xing published the artcileSelective synthesis of acylated caprolactam via sequential Michael addition/palladium-catalyzed alpha-arylation of ketones, Application In Synthesis of 1468-83-3, the main research area is acylated caprolactam preparation diastereoselective; methyl ketone acrylamide Michael addition alpha arylation palladium catalyst.

A formal [6 + 1] annulation reaction through sequential Michael addition/palladium-catalyzed alpha-arylation of ketones has been developed. This approach provides an efficient route enabling rapid access to diverse acylated caprolactams by the double C-C bond formation of the same site from Me ketones. In addition, the reaction features a broad substrate scope, good functional group tolerance, easy scale-up of reaction and useful transformations of the products.

Organic Chemistry Frontiers published new progress about Acrylamides Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Application In Synthesis of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Otvos, Sandor B. published the artcileBismuth(III)-Catalyzed Hydration of Terminal Alkynes: Sustainable Synthesis of Methyl Ketones in Batch and Flow, Name: 3-Acetylthiophene, the main research area is methyl ketone batch preparation bismuth catalyst alkyne hydration.

Environmentally benign synthesis of Me ketones is demonstrated via unprecedented bismuth(III)-catalyzed activation and Markovnikov-type hydration of terminal acetylenes. Besides a batch process operating under reasonably mild conditions, a chem. intensified high-temperature continuous-flow methodol. also was developed using a coil reactor. The preparative capabilities of the flow process were demonstrated with multigram-scale alkyne hydrations. The methods presented rely on readily available bismuth(III) salts as “”green”” catalysts and exhibit less environmental concerns than earlier methods.

ACS Sustainable Chemistry & Engineering published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Name: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Laha, Joydev K. published the artcileMinisci aroylation of N-heterocycles using choline persulfate in water under mild conditions, Safety of 3-Acetylthiophene, the main research area is acyl isoquinoline indole preparation green chem choline persulfate mediated; isoquinoline indoel arylglyoxylic acid Minisci aroylation choline persulfate.

Metal persulfate mediated thermal oxidative organic transformations invariably require a higher temperature and frequently use an organic solvent. The objective of this work was to develop persulfate mediated oxidative transformations that can be performed nearly at room temperature using water as a solvent. This report describes modified Minisci aroylation of isoquinolines with arylglyoxylic acids using choline persulfate and its pre-composition (choline acetate and K2S2O8) in water at 40°C. A few other nitrogen heterocycles were also utilized affording various aroylated products in good to excellent yields. Unlike metal persulfate that could produce metal salt byproducts, a key feature of the chem. reported herein includes the use of environmentally benign choline persulfate containing biodegradable choline as a counter-cation, the Minisci reaction demonstrated at 40°C in water as the only solvent, and unconventional activation of persulfate.

New Journal of Chemistry published new progress about Aryl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Safety of 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Vigneswaran, Vipulan published the artcileBeta-amino phosphine Mn catalysts for 1,4-transfer hydrogenation of chalcones and allylic alcohol isomerization, Safety of 3-Acetylthiophene, the main research area is amino phosphine Mn catalyst preparation transfer hydrogenation chalcone isomerization; transfer hydrogenation chalcone allylic alc isomerization.

Mn complexes with amino acid derived PN ligands were used in the catalytic transfer hydrogenation (TH) of ketone and chalcone substrates in 2-propanol with mild heating. Moreover, chalcones are reduced selectively to the saturated ketone at short times and can be fully converted to the alc. when reactions are prolonged. The mechanism of chalcone reduction was briefly considered. Allylic alcs. are not reactive in 2-propanol, but quant. isomerization occurs in toluene. Thus, we suspect that the allylic alcs. are dehydrogenated and the resulting ketone is formed through a direct 1,4-hydrogenation of the chalcone. Finally, several other related ligands that have been used in Mn-based TH reactions were explored to test the viability of ligand design in favoring chemoselectivity. The β-amino phosphine ligands proved most effective in this regard. Mn complexes with amino acid-derived PN ligands were used to enact catalytic transfer hydrogenation (TH) of ketone and chalcone substrates in 2-proponal with mild heating. Moreover, chalcones are reduced selectively to the saturated ketone at short times and can be fully converted to the alc. under prolonged reactions. The mechanism of chalcone reduction was briefly considered. Allylic alcs. are not reactive in 2-proponal, but quant. isomerization occurs in toluene. Thus, we suspect that the allylic alcs. are dehydrogenated and the resulting ketone is formed through a direct 1,4-hydrogenation of the chalcone. Finally, several other related ligands that have been used in Mn-based TH reactions were explored to test the viability of ligand design in favoring chemoselectivity. The beta-amino phosphine ligands proved most effective in this regard.

Organometallics published new progress about Allylic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Safety of 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Cao, Fei published the artcileThe preparation of a Co@C3N4 catalyst and applications in the synthesis of quinolines from 2-aminobenzyl alcohols with ketones, Category: benzothiophene, the main research area is cobalt doped carbon nitride catalyst quinoline synthesis aminobenzenemethanol ketone.

An unsym. diphenylphosphino-pyridinyl-triazole ligand was synthesized and characterized through IR, NMR and MS and the corresponding earth-abundant metal complex (cobalt) was prepared Considering energy consumption and environmental friendliness, it is necessary to turn this diphenylphosphino-pyridinyl-triazole cobalt complex into a recyclable catalyst, which could easily be reused. Therefore, a heterogeneous catalyst was synthesized through Co-doping of C3N4, and the Co-nanoparticles on C3N4 revealed high catalytic activity for the synthesis of quinolines with good recovery performance.

New Journal of Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Category: benzothiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Wang, Li-Sheng published the artcileIodine-Mediated Multicomponent Cascade Cyclization and Sulfenylation/Selenation: Synthesis of Imidazo[2,1-a]isoquinoline Derivatives, Recommanded Product: 3-Acetylthiophene, the main research area is aryl methyl ketone isoquinolinamine sodium arylsulfinate multicomponent cyclization sulfenylation; isoquinolinamine aryl methyl ketone diphenyldiselane multicomponent cascade cyclization selenation; imidazo isoquinoline preparation green chem iodine mediator.

A novel multicomponent cascade cyclization and sulfenylation/selenation using aryl Me ketones, isoquinolin-1-amine, and sodium arylsulfinates/1,2-diphenyldiselane to synthesize imidazo[2,1-a]isoquinoline derivatives in one-pot via the construction of two C-N bonds and one C-S/C-Se bond has been reported. This multicomponent reaction realizes simultaneous C(sp3)-H amination and sulfenylation/selenation, avoiding complicated prior substrate preparation This process has simple operating conditions and good substrate compatibility.

Organic Letters published new progress about Aralkyl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Tamuli, Kashyap J. published the artcileRecyclable Itaconic Acid with Water as Green Catalytic System: Synthesis of Substituted 1,5-Benzodiazepine Derivatives at Room Temperature, Synthetic Route of 1468-83-3, the main research area is benzodiazepine green preparation; phenylenediamine ketone cyclocondensation itaconic acid catalyst.

Herein, a water-mediated and metal-free mild protocol was described for the synthesis of 1,5-benzodiazepine derivatives I [R = i-Pr, Ph, 3-thienyl, etc.; R1 = H, 7-Me, 8-Me, 7-Cl, 8-Cl] via cyclocondensation reaction of o-phenylenediamines and ketones by using biodegradable naturally occurring itaconic acid (20 mol%) in 30 min with excellent yields. Major advantages of this method were reusable catalyst, metal free, toxic solvent free, tedious work-up free, no further purifications with column chromatog. and short reaction time.

ChemistrySelect published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Synthetic Route of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Zhao, Peng published the artcileDirect Synthesis of 2,3-Diaroyl Quinolines and Pyridazino[4,5-b]quinolines via an I2-Promoted One-Pot Multicomponent Reaction, COA of Formula: C6H6OS, the main research area is pyridazino diaroyl quinoline preparation iodine enaminone ketone aryl amine.

The first synthesis of 2,3-diaroyl quinolines via a formal [3 + 2 + 1] cycloaddition of enaminones, aryl Me ketones, and aryl amines is disclosed. This reaction efficiently affords a 1,4-dicarbonyl scaffold, which is a useful building block for constructing complex fused heterocycles. Furthermore, the 1,4-dicarbonyl scaffold was used directly to prepare pyridazino[4,5-b]quinoline skeletons in one-pot.

Organic Letters published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, COA of Formula: C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Gupta, Shivangi published the artcileCuO NPs catalyzed synthesis of quinolines, pyridines, and pyrroles via dehydrogenative coupling strategy, Application In Synthesis of 1468-83-3, the main research area is hydroxymethyl aniline ketone copper nanocatalyst oxidative coupling reaction; quinoline preparation; hydroxypropanamine ketone copper nanocatalyst oxidative coupling reaction; pyridine preparation; hydroxyethanamine ketone copper nanocatalyst oxidative coupling reaction; pyrrole preparation.

Copper oxide nanoparticles catalyzed efficient synthesis of quinolines, pyridines, and pyrroles via alc. dehydrogenative coupling strategy are reported. Employing this catalytic system, various functionalized quinolines, pyridines, and pyrroles were synthesized efficiently from different amino alcs. with a diverse range of ketones. A number of control experiments were performed to shed light on the mechanism. This catalyst was recycled up to 6th run and notably, no significant loss was observed in its catalytic activity.

Journal of Catalysis published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Application In Synthesis of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem