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The first general methodology for the direct thiolation of electron-rich heteroarenes was developed by employing Pd/Al2O3, a recoverable and commercially available heterogeneous catalyst, and CuCl2. This method represents an operationally simple approach for the synthesis of these valuable compounds. Preliminary mechanistic studies indicate a heterogeneous catalytic system, in which both metals play a complementary role in the formation of the thiolated products. (Hetero)genius: A general method for the direct thiolation of electron-rich heteroarenes was developed by employing Pd/Al2O3, a recoverable and commercially available heterogeneous catalyst, and CuCl2. Preliminary mechanistic studies indicate a heterogeneous active catalytic species, with the two metals playing complementary roles in the formation of the thiolated products.

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A class of N-(naphthalen-1-yl)-N?-alkyl oxalamides have been proven to be powerful ligands, making a coupling reaction of (hetero)aryl iodides with primary amines proceed at 50 C with only 0.01 mol % of Cu2O and ligand as well as a coupling reaction of (hetero)aryl bromides with primary amines and ammonia at 80 C with only 0.1 mol % of Cu2O and ligand. A wide range of coupling partners work well under these conditions, thereby providing an easy to operate method for preparing (hetero)aryl amines.

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?????????????(1)?????????????????????????????????????????????????????????????????????????????? The present invention provides a material for photoelectric conversion element for use in imaging element contain a compound represented by the following formula (1). The material can provide a photoelectric conversion element excellent in hole or electron leak prevention property, hole or electron transporting property, heat resistance against process temperature, visible light transparency and the like. (In the formula (1), R1and R2independently represent a substituted or unsubstituted heterocyclic condensed aromatic group).

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The invention discloses a formula (I) containing the structure shown as the imidazole fused three-ring compound or its pharmaceutically acceptable salt or a stereoisomer thereof or its prodrug molecule. The compound has adjusting IDO1 active role, such compounds by blocking immune checkpointing IDO1, T cell activation can be enhanced, used for the treatment of IDO1 mediated immune suppression, thus can become effective drug for the treatment of malignant tumor. With the checkpointing the antibody of the protein drug or other anti-cancer drugs share, can enhance the anti-cancer effects. At the same time also has the potential to effectively treat with IDO1 related with the immunosuppressive disease, have high application value. (by machine translation)

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A highly selective C-H silylation reaction of functionalized arenes and heteroarenes was developed using Ruppert-Prakash reagent (TMSCF3) activated by alkali metal fluoride. TMSCF3 is considered to play dual roles as a precursor of a mild base and also as a silicon electrophile. The silylation is compatible with sensitive functional groups such as halogen and nitro groups.

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In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. The reactant in an enzyme-catalyzed reaction is called a substrate. COA of Formula: C8H5BrS, C8H5BrS. A document type is Patent, introducing its new discovery., COA of Formula: C8H5BrS

The present invention is a method for the glucose related disorders and lipid related disorders comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel b benzo-heteroaryl sulfamide derivatives of formula (I) as herein defined. The present invention is further directed to methods of treatment comprising co-therapy with an anti-diabetic agent, and anti-lipid agent and/or an anti-obesity agent.

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A range of bench-stable carbazole-containing hypervalent iodine(III) reagents were synthesized by I ? N bond formation in good yields. This kind of benziodoxolone reagents was used for a C[sbnd]N coupling reaction to introduce a carbazole group to aromatic heterocycle compounds.

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The development of the oxidative cross-coupling of unreactive C(sp3)-H bonds with (hetero)arene C(sp2)-H bonds is considerably appealing, yet conceptually and practically challenging. Here, we disclose the rhodium-catalyzed oxidative heteroarylation of unactivated C(sp3)-H bonds with heteroarene C(sp2)-H bonds. This method provides a step-economic route to beta-heteroarylated 2-ethylpyridine derivatives, which exhibits relatively broad substrate scope, high tolerance level of sensitive functional groups, and high selectivity. The protocol can also be extended to the coupling reaction between 8-methylquinoline derivatives and heteroarenes.

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The purpose of the present invention is to provide a method for easily producing a fluorine-containing (cyclo)alkenyl zinc halide compound at low cost. The present invention provides a method for producing a fluorine-containing (cyclo)alkenyl zinc halide compound represented by formula (1) (wherein A1 represents a perfluoroalkyl group having 1-12 carbon atoms, or a fluorine atom; A2 represents a fluorine atom or a hydrogen atom; A3 represents a fluorine atom or a hydrogen atom, or alternatively A3 and A1 or A2 may combine together to form a perfluoroalkylene chain having 1-12 carbon atoms; and X’ represents a halogen atom), which comprises a step wherein a fluorine-containing olefin represented by formula (2) (wherein X” represents a fluorine atom or a chlorine atom; and the other symbols are as defined above) is reacted with a zinc halide represented by formula ZnX’2 (wherein the symbol is as defined above) in the presence of one or more metals that are selected from among magnesium and magnesium alloys.

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Using triphenylmethylium tetrakis(pentafluorophenyl)borate as a convenient Br°nsted acid precatalyst, beta-(alpha,alpha-dimethylbenzyl)styrenes are shown to cyclize efficiently to afford a variety of new indanes that possess a benzylic quaternary center. The geminal dimethyl-containing quaternary center is proposed to be necessary to arm the substrate for cyclization through steric biasing.

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