Category: 5381-20-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

EXAMPLE 167 (2-Benzo[b]thiophen-3-yl-cyclopropylmethyl)-dimethyl-amine Diethyl (N-methoxy-N-methylcarbamoylmethyl)phosphonate (6.13 g, 25.6 mmol) was added dropwise via syringe to a stirred suspension of sodium hydride (1.02 g, 25.6 mmol) in anhydrous THF (75 ml) at 0 C. The reaction was warmed to room temperature and was stirred for 1 h. After cooling to 0 C., benzo[b]thiophene-3-carbaldehyde (3.78 g, 23.3 mmol) was added. The resulting mixture was stirred at room temperature for 1 hr. The reaction was quenched with 100 mL aqueous HCl (0.1 N) and extracted with ethyl acetate (250 ml). The combined organic layers were washed with brine (50 ml) and dried over anhydrous magnesium sulfate. The filtrate was concentrated in vacuo and triturated with hexane to give (E)-3-benzo[b]thiophen-3-yl-N-methoxy-N-methyl-acrylamide (5.38 g, 93%) as a yellow solid. 1H NMR (500 MHz, CDCl3) 8.06-8.01 (2 H, 2 superimposed d, J=8.24, 15.87 Hz), 7.89 (1 H, d, J=7.94 Hz), 7.78 (1 H, s), 7.47 (1 H, t, J=7.93 Hz), 7.41 (1 H, t, J=8.24 Hz), 7.13 (1 H, d, J=15.87 Hz), 3.79 (3 H, s), 3.34 (3 H, s); MS m/e 248.07 (M+H)+., 5381-20-4

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Mattson, Ronald J.; Denhart, Derek John; Deskus, Jeffrey A.; Ditta, Jonathan L.; Marcin, Lawrence R.; Epperson, James R.; Catt, John D.; King, Dalton; Higgins, Mendi A.; US2003/73849; (2003); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, General procedure: To a 25 mL round bottom flask equipped with a stir bar and reflux condenser was added the carbonyl substrate (1 mmol), NaBH4 (1 mmol) and 5 mL of diethyl carbonate or dimethyl carbonate. The reaction mixture was heated at reflux temperature for six hours. The reaction was cooled and rinsed with diethyl ether through a bed of celite on silica in a fritted funnel. The solvent was removed in vacuo and the product purified via flash chromatography over silica gel using gradient elution with EtOAc and hexanes.

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Article; Osumah, Abdulakeem; Magolan, Jakob; Waynant, Kristopher V.; Tetrahedron Letters; vol. 60; 44; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5381-20-4

General procedure: As a typical experiment, the reaction of the aryl bromide (1 mmol), benzothiophene (1.5 mmol) and KOAc (0.196 g, 2 mmol) at 150C during 16 h in DMF or DMAc (4 mL) in the presence of Pd(OAc)2 (0.224 mg,0.001 mmol) or (1.12 mg, 0.005 mmol) prepared as a solution in DMAc (1 mg of Pd(OAc)2 in 1 mL of DMAc) under argon affords the coupling product after evaporation of the solvent and purificationon silica gel.

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhao, Liqin; Bruneau, Christian; Doucet, Henri; Tetrahedron; vol. 69; 34; (2013); p. 7082 – 7089;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

5381-20-4, General procedure: Sulfanilamide (1.0 equiv) was dissolved in dry MeOH and theappropriate aldehyde (1.0 equiv) was added to the reaction. Thesolution was stirred until the formation of a precipitate was completedwhich was collected by filtration, washed with ice-coldMeOH and dried under vacuo to afford the desired compounds 1-17.

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Article; Sarikaya, Busra; Ceruso, Mariangela; Carta, Fabrizio; Supuran, Claudiu T.; Bioorganic and Medicinal Chemistry; vol. 22; 21; (2014); p. 5883 – 5890;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, [0359j To a solution of 2-D (200 mg, 0.71 mmol) in anhydrous ethanol (30 mL) was added benzo[b]thiophene-3-carbaldehyde (2-E) (150 mg, 0.92 mmol) and AcOH (0.1 mL), the mixture was stirred at 50C for 15 h. Then the mixture was allowed to cool to rt and a white precipitate was formed in the solution. The precipitate was filtered and washed with EtOAc to afford compound 200 as a white solid (118 mg, 38.9%). +ESI-MS:mlz 428.0 [M+H].

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Patent; ALIOS BIOPHARMA, INC.; WANG, Guangyi; BEIGELMAN, Leonid; TRUONG, Anh; NAPOLITANO, Carmela; ANDREOTTI, Daniele; HE, Haiying; WO2014/31784; (2014); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

5381-20-4, General procedure: To a suspension of Yb(OTf)3 (207 mg,0.334 mmol) and TMSCl (0.850 mL, 6.70 mmol) in CH2Cl2 (4 mL) was added dropwise a solution ofaldehyde 3a (50.1 mg, 0.330 mmol) and Et3N (1.86 mL, 13.3 mmol) in CH2Cl2 (1 mL) at 0 C. The mixturewas stirred at room temperature for 24 h. Saturated aqueous NaHCO3 solution was added at 0 C, and thenthe resulting mixture was stirred at room temperature for 30 min. After separation, the aqueous layer wasextracted with CH2Cl2. The combined organic layers were washed with brine and dried over MgSO4. Afterremoval of the solvent, the residue was chromatographed. Elution with a 2:1 mixture of hexane-EtOAcfurnished 4a4 (34.1 mg, 58%) as a color less oil.

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various.

Reference£º
Article; Kagawa, Natsuko; Sasaki, Yoshiko; Sakaguchi, Shoko; Nagatomo, Ayumi; Kojima, Hideo; Toyota, Masahiro; Heterocycles; vol. 8; 2; (2014); p. 1581 – 1585;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem