Category: benzothiophene

Syntheses and properties of 1-(2-ethyl-1-benzofuran-3-yl)-2-(2-methyl-1-benzothiophene-3-yl) Perfluorocyclopentene was written by Tian, Zhaoyan;Sun, Fengxia;Pu, Shouzhi. And the article was included in Applied Mechanics and Materials in 2014.Application In Synthesis of 2-Methylbenzo[b]thiophene This article mentions the following:

An unsym. diarylethene compound 1-(2-methyl-1-benzofuran-3-yl)-2-[2-methyl-1-benzothiophene-3-yl] Perfluorocyclopentene was synthesized and its photochromism was investigated, the results showed that this compound exhibited reversible photochromism, inducing cyclization and cycloreversion reactions upon alternating irradiation with UV and visible light both in solution and in PMMA film. When irradiated 297 nm UV light, the maximum absorption was observed at 498 nm and 509 nm in hexane solution and in PMMA film, resp. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Application In Synthesis of 2-Methylbenzo[b]thiophene).

2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Application In Synthesis of 2-Methylbenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A Broadly Applicable Method for Pd-Catalyzed Carboperfluoro-alkylation of Terminal and Internal Alkynes: A Convenient Route to Tri- and Tetrasubstituted Olefins was written by Domanski, Sylwester;Chaladaj, Wojciech. And the article was included in ACS Catalysis in 2016.Recommanded Product: Benzo[b]thiophen-3-ylboronic acid This article mentions the following:

Perfluoroalkyl-substituted tri- and tetrasubstituted aryl alkenes and alkenes were prepared by three-component Pd-catalyzed difunctionalization of internal and terminal alkynes with iodoperfluoroalkanes and (aryl) boronic acids in the presence of a palladium BINAP-substituted palladacycle precatalyst; reactions of terminal and internal aryl alkynes yielded products with high regio- and stereoselectivities, while dialkyl alkynes yielded mixtures of regioisomeric tetrasubstituted alkenes with high stereoselectivities. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Recommanded Product: Benzo[b]thiophen-3-ylboronic acid).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Recommanded Product: Benzo[b]thiophen-3-ylboronic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Correction to “Predicting Flash Points of Pure Compounds and Mixtures with COSMO-RS” [Erratum to document cited in CA164:106271] was written by Reinisch, Jens;Klamt, Andreas. And the article was included in Industrial & Engineering Chemistry Research in 2016.Name: 2-Methylbenzo[b]thiophene This article mentions the following:

The final conversion within eq 4 in the original manuscript is incorrect; The correct equation has been given. There is an analog error in eq 11; The corrected equation has been given. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Name: 2-Methylbenzo[b]thiophene).

2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Name: 2-Methylbenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Palladium-Catalyzed Alkynylation of Enones with Alkynylsilanes via C-C Bond Activation was written by Liu, Yu-Wen;Li, Ling-Jun;Xu, Hui;Dai, Hui-Xiong. And the article was included in Journal of Organic Chemistry in 2022.SDS of cas: 4298-52-6 This article mentions the following:

The synthesis of 1,3-enynes via palladium-catalyzed cross coupling between enone derivatives and alkynylsilanes was reported. The employment of appropriate pyridine-oxazoline ligand is the key to the C-C cleavage and the high E/Z stereoselectivity. This protocol features broad substrate scope and wide functional-group tolerance, affording the desired products in moderate-to-good yields. Late-stage diversification of natural product β-ionone further demonstrated the synthetic utility of this protocol. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6SDS of cas: 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.SDS of cas: 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Catalytic activity and mechanistic investigation of 1D 2-picolinic acid based Cu(II) coordination polymer in the selective construction of 1,4-disubstituted triazoles was written by Aier, Merangmenla;Gayen, Firdaus Rahaman;Puzari, Amrit. And the article was included in Scientific Reports in 2022.COA of Formula: C6H4S This article mentions the following:

The catalytic activity of 1D 2-picolinic acid based Cu(II) coordination polymer (CP1) in click reaction to selectively generate 1,4-disubstituted 1,2,3-triazoles has been evaluated. The CP1 catalyst loading of 2 mol% was applied successfully in the reactions of primary azides with diverse terminal alkynes in green solvent (aqueous ethylene glycol). Moreover, the one-pot, multicomponent click reaction involving benzyl bromide, sodium azide, and phenylacetylene was also catalyzed by CP1. The findings show that 2-picolinic acid based Cu(II) coordination polymer catalytic systems are highly efficient for green click triazoles synthesis. DFT calculation supported the plausible mechanism involved in the CP1 catalyzed click reaction. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6COA of Formula: C6H4S).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.COA of Formula: C6H4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural Characterization was written by Whelligan, Daniel K.;Solanki, Savade;Taylor, Dawn;Thomson, Douglas W.;Cheung, Kwai-Ming J.;Boxall, Kathy;Mas-Droux, Corine;Barillari, Caterina;Burns, Samantha;Grummitt, Charles G.;Collins, Ian;van Montfort, Rob L. M.;Aherne, G. Wynne;Bayliss, Richard;Hoelder, Swen. And the article was included in Journal of Medicinal Chemistry in 2010.Formula: C6H8S This article mentions the following:

We report herein the first systematic exploration of inhibitors of the mitotic kinase Nek2. Starting from HTS hit aminopyrazine I, compounds with improved activity were identified using structure-based design. Our structural biol. investigations reveal two notable observations. First, I and related compounds bind to an unusual, inactive conformation of the kinase which to the best of our knowledge has not been reported for other types of kinase inhibitors. Second, a phenylalanine residue at the center of the ATP pocket strongly affects the ability of the inhibitor to bind to the protein. The implications of these observations are discussed, and the work described here defines key features for potent and selective Nek2 inhibition, which will aid the identification of more advanced inhibitors of Nek2. In the experiment, the researchers used many compounds, for example, 3-Ethylthiophene (cas: 1795-01-3Formula: C6H8S).

3-Ethylthiophene (cas: 1795-01-3) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Formula: C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Bimetallic CoNi Nanoflowers for Catalytic Transfer Hydrogenation of Terminal Alkynes was written by Choudhary, Neha;Kumar, Viresh;Mobin, Shaikh M.. And the article was included in ChemistrySelect in 2022.Product Details of 4298-52-6 This article mentions the following:

The development of bimetallic and magnetic nanomaterials as a catalyst is highly desirable for organic transformations due to their recyclability for the sustainable future of chem. industries. Bimetallic CoNi nanoflowers were developed via the facile liquid-phase reduction method and were employed for the hydrogenation of terminal alkynes. The structural and morphol. studies were analyzed by X-ray diffraction, Field-Emission SEM, and High Resolution Transmission Electron Microscopy. The bimetallic CoNi nanoflower exhibited 100% conversion with ∼100% selectivity towards alkane products with recyclability up to six cycles. The transfer hydrogenation mechanism was proposed via diimide formation with Co(0)/Ni(0) state, confirmed by X-ray Photoemission Spectroscopy anal. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Product Details of 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Product Details of 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Determination of thermal decomposition products of glucose by thermal analysis combined with FTIR and GC-MS was written by Liu, Chun-bo;Shen, Qin-peng;Yang, Guang-yu;Si, Xiao-xi;He, Pei;Wang, Kun-miao;Zhang, Hong-yu;Liu, Zhi-hua;Miao, Ming-ming. And the article was included in Lihua Jianyan, Huaxue Fence in 2014.SDS of cas: 1795-01-3 This article mentions the following:

A combination of thermal anal., FTIR and GC-MS was applied to the determination of thermal decomposition products of glucose. Under conditions of simultaneous thermal anal., the glucose sample was pyrolyzed in atm. of nitrogen and nitrogen oxygen gas mixture, and determined by IR scanning. GC-MS temperature was chosen with thermogravimetric curves and IR spectra. Products of pyrolysis were separated and identified by GC-MS. The exptl. results showed that, 44 compounds were detected in the thermal decomposition products of glucose at temperature of 220°C, 300°C, 350°C and 470°C; 76 compounds were detected in pyrolysis products of glucose at high temperature The anal. results were valuable for the application of glucose at different temperatures In the experiment, the researchers used many compounds, for example, 3-Ethylthiophene (cas: 1795-01-3SDS of cas: 1795-01-3).

3-Ethylthiophene (cas: 1795-01-3) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.SDS of cas: 1795-01-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Identifying chondroprotective diet-derived bioactives and investigating their synergism was written by Davidson, Rose K.;Green, Jonathan;Gardner, Sarah;Bao, Yongping;Cassidy, Aedin;Clark, Ian M.. And the article was included in Scientific Reports in 2018.SDS of cas: 7128-64-5 This article mentions the following:

Osteoarthritis (OA) is a multifactorial disease and nutrition is a modifiable factor that may contribute to disease onset or progression. A detailed understanding of mechanisms through which diet-derived bioactive mols. function and interact in OA is needed. We profiled 96 diet-derived, mainly plant-based bioactives using an in vitro model in chondrocytes, selecting four candidates for further study. We aimed to determine synergistic interactions between bioactives that affected the expression of key genes in OA. Selected bioactives, sulforaphane, apigenin, isoliquiritigenin and luteolin, inhibited one or more interleukin-1-induced metalloproteinases implicated in OA (MMP1, MMP13, ADAMTS4, ADAMTS5). Isoliquiritigenin and luteolin showed reactive oxygen species scavenging activity in chondrocytes whereas sulforaphane had no effect and apigenin showed only a weak trend. Sulforaphane inhibited the IL-1/NFκB and Wnt3a/TCF/Lef pathways and increased TGFβ/Smad2/3 and BMP6/Smad1/5/8 signalling. Apigenin showed potent inhibition of the IL-1/NFκB and TGFβ/Smad2/3 pathways, whereas luteolin showed only weak inhibition of the IL-1/NFκB pathway. All four bioactives inhibited cytokine-induced aggrecan loss from cartilage tissue explants. The combination of sulforaphane and isoliquiritigenin was synergistic for inhibiting MMP13 gene expression in chondrocytes. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5SDS of cas: 7128-64-5).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.SDS of cas: 7128-64-5

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Some derivatives of dibenzothiophene was written by Brown, Robert K.;Christiansen, Robert G.;Sandin, Reuben B.. And the article was included in Journal of the American Chemical Society in 1948.Application of 25288-76-0 This article mentions the following:

Dibenzothiophene (15 g.) in 150 ml. CCl₄, treated at 0-5° with 6 g. Cl and the addition compound hydrolyzed by shaking with ice and H₂O, gives 77% of the 5-oxide (I), m. 185-7°. I (15 g.), 33 ml. AcOH, and 33 ml. concentrated H₂SO₄ at 0° treated (15 min.) with 36 ml. HNO₃ (d. 1.5), kept 30 min. at 0-5°, and poured onto ice, give 76% 3-nitrodibenzothiophene 5-oxide (II), m. 209.5-10.5°. II (10 g.) in 100 ml. AcOH, reduced with 51 g. SnCl₂.2H₂O in 65 ml. concentrated HCl, gives 65% 3-aminodibenzothiophene, m. 121-2.5°. II (5 g.) in 60 ml. AcOH, treated with 26 g. SnCl₂.2H₂O in 40 ml. 6 N HCl, kept 30 min. at 40° and 3 hrs. at room temperature, gives 91% 3-aminodibenzothiophene 5-oxide, light yellow, m. 208-9°; Ac derivative, light yellow, m. 265-7°. In the experiment, the researchers used many compounds, for example, Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0Application of 25288-76-0).

Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Application of 25288-76-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem