Category: benzothiophene

Substituent and solvent effects on the fluorescent and photochromic properties of 2-(2-pyridyl)imidazole containing diarylethene derivatives was written by Peng, Xuefeng;Deng, Jian-Guo;Xu, Hai-Bing. And the article was included in RSC Advances in 2013.Related Products of 10243-15-9 This article mentions the following:

Five diarylethene derivatives with 2-(2-pyridyl)imidazole as the ethene bridges (PI-BTEs) were synthesized and characterized. The structures and performances of these PI-BTEs could be modified from not only the thiophene unit, but also the substituent on the imidazole nitrogen. Noteworthily, replacing the thiophene with the benzothiophene, the fatigue resistance is significantly improved, the center absorption bands of the closed forms shift from 572 nm (dithiophene derivative) to 550 nm (dibenzothiophene derivative) , and the colors of the solutions change from pale pink in dithiophene derivative to red-purple in dibenzothiophene derivative Addnl., the Stokes shift Δν values of dithiophene derivative in various solvents display good linear relationships with the donor number (DN) of the solvents, and the solvent polarity parameter Δf. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Related Products of 10243-15-9).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Related Products of 10243-15-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Identification of Novel d-Amino Acid Oxidase Inhibitors by in Silico Screening and Their Functional Characterization in Vitro was written by Katane, Masumi;Osaka, Naoko;Matsuda, Satsuki;Maeda, Kazuhiro;Kawata, Tomonori;Saitoh, Yasuaki;Sekine, Masae;Furuchi, Takemitsu;Doi, Issei;Hirono, Shuichi;Homma, Hiroshi. And the article was included in Journal of Medicinal Chemistry in 2013.Reference of 70060-13-8 This article mentions the following:

D-Amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for d-amino acids, including d-serine and d-alanine, which are potential coagonists of the N-methyl-d-aspartate (NMDA) receptor. Dysfunction of NMDA receptor-mediated neurotransmission has been implicated in the onset of various mental disorders such as schizophrenia. Hence, a DAO inhibitor that augments the brain levels of d-serine and/or d-alanine and thereby activates NMDA receptor function is expected to be an antipsychotic drug, for instance, in the treatment of schizophrenia. In the search for potent DAO inhibitor(s), a large number of compounds were screened in silico, and several compounds were estimated as candidates. These compounds were then characterized and evaluated as novel DAO inhibitors in vitro. The results reported in this study indicate that some of these compounds are possible lead compounds for the development of a clin. useful DAO inhibitor and have the potential to serve as active site probes to elucidate the structure-function relationships of DAO. In the experiment, the researchers used many compounds, for example, 5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8Reference of 70060-13-8).

5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is also used in the manufacturing of dyes such as thioindigo.Reference of 70060-13-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A novel aggregation-induced emission platform from 2,3-diphenylbenzo[b]thiophene S,S-dioxide was written by Guo, Jingjing;Hu, Shimin;Luo, Wenwen;Hu, Rongrong;Qin, Anjun;Zhao, Zujin;Tang, Ben Zhong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Recommanded Product: 2,3-Dibromobenzo[b]thiophene This article mentions the following:

New aggregation-induced emission (AIE) luminogens with high solid-state emission efficiencies are developed by adopting a benzo[b]thiophene S,S-dioxide core, and steric and electronic effects on the AIE property are elucidated. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Recommanded Product: 2,3-Dibromobenzo[b]thiophene).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Recommanded Product: 2,3-Dibromobenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Transition-Metal-Free Cross-Coupling of Benzothiophenes and Styrenes in a Stereoselective Synthesis of Substituted (E,Z)-1,3-Dienes was written by Siauciulis, Mindaugas;Ahlsten, Nanna;Pulis, Alexander P.;Procter, David J.. And the article was included in Angewandte Chemie, International Edition in 2019.Formula: C9H5NS This article mentions the following:

A transition metal-free one-pot stereoselective approach to substituted (E,Z)-1,3-dienes was developed by using an interrupted Pummerer reaction/ligand-coupling strategy. Readily available benzothiophene S-oxides, which can be conveniently prepared by oxidation of the parent benzothiophenes, undergo Pummerer coupling with styrenes. Reaction of the resultant sulfonium salts with alkyllithium/magnesium reagents generates underexploited hypervalent sulfurane intermediates that undergo selective ligand coupling, resulting in dismantling of the benzothiophene motif and the formation of decorated (E,Z)-1,3-dienes. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Formula: C9H5NS).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Formula: C9H5NS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis of photochromic diarylethenes using a microflow system was written by Ushiogi, Yousuke;Hase, Tomoyuki;Iinuma, Yoshiharu;Takata, Atsushi;Yoshida, Jun-ichi. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2007.COA of Formula: C9H7BrS This article mentions the following:

An effective method for the synthesis of photochromic diarylethenes based on microflow systems has been developed, and the synthesis of unsym. diarylethenes which is difficult to achieve using conventional macro batch systems, has been accomplished. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9COA of Formula: C9H7BrS).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.COA of Formula: C9H7BrS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Convenient synthesis of photochromic symmetrical or unsymmetrical bis(heteroaryl)maleimides via the Suzuki-Miyaura cross-coupling reaction was written by El Yahyaoui, A.;Felix, G.;Heynderickx, A.;Moustrou, C.;Samat, A.. And the article was included in Tetrahedron in 2007.Reference of 10243-15-9 This article mentions the following:

A general method for the synthesis of sym. or unsym. bis(heteroaryl)maleimides by a one-pot procedure involving Suzuki-Miyaura cross-coupling sequence was developed on the basis of the reaction of 3,4-diiodo-1-benzyl-1H-pyrrole-2,5-dione with cyclic boronate esters using [1,1′-bis(diphenylphosphino)-ferrocene]dichloropalladium(II) as the catalyst. Photochromic properties of the products were examined In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Reference of 10243-15-9).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Reference of 10243-15-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Robust Palladium-Catalyzed Arylation of Catalyst-Poisoning ortho-Sulfanyl Aryl Halides with Tetraarylborates and Its Application to Synthesis of π-Extended Dibenzothiophenes was written by Vasu, Dhananjayan;Hausmann, Jan Niklas;Saito, Hayate;Yanagi, Tomoyuki;Yorimitsu, Hideki;Osuka, Atsuhiro. And the article was included in Asian Journal of Organic Chemistry in 2017.Application In Synthesis of 2,3-Dibromobenzo[b]thiophene This article mentions the following:

Bis(tri-tert-butylphosphine)palladium-catalyzed arylation of ortho-sulfanyl aryl halides with sodium tetraarylborates proceeds smoothly without any addnl. bases in high yields, providing a reliable route to 2-sulfanylbiaryls. The conditions are applicable to aryl chloride and iodide as well as bromides. A variety of functional groups were tolerated. This arylation protocol offers a practical solution to overcome the poisoning behavior of aryl sulfides in such cross-coupling arylation. In addition, this strategy provides a short and efficient access to dibenzothiophenes in combination with a Pummerer-type cyclization. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Application In Synthesis of 2,3-Dibromobenzo[b]thiophene).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Application In Synthesis of 2,3-Dibromobenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety was written by Richardson, Timothy I.;Frank, Scott A.;Wang, Minmin;Clarke, Christian A.;Jones, Scott A.;Ying, Bai-Ping;Kohlman, Dan T.;Wallace, Owen B.;Shepherd, Timothy A.;Dally, Robert D.;Palkowitz, Alan D.;Geiser, Andrew G.;Bryant, Henry U.;Henck, Judith W.;Cohen, Ilene R.;Rudmann, Daniel G.;McCann, Denis J.;Coutant, David E.;Oldham, Samuel W.;Hummel, Conrad W.;Fong, Kin C.;Hinklin, Ronald;Lewis, George;Tian, Hongqi;Dodge, Jeffrey A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Reference of 90560-10-4 This article mentions the following:

Structure-activity relationship studies are described, which led to the discovery of novel selective estrogen receptor modulators (SERMs) for the potential treatment of uterine fibroids. The SAR studies focused on limiting brain exposure and were guided by computational properties. Compounds with limited impact on the HPO axis were selected using serum estrogen levels as a biomarker for ovarian stimulation. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Reference of 90560-10-4).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Reference of 90560-10-4

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Photochromic composite properties and application in optical memory of a diarylethene with benzofuran unit was written by Jing, Shuhong;Cui, Shiqiang;Pu, Shouzhi. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2012.HPLC of Formula: 10243-15-9 This article mentions the following:

A new photochromic diarylethene, 1-[2-methyl-(5-(4- dioxolane)phenyl) -3-thienyl]-2-(2-methyl-3-benzofuran) perfluorocyclopentene (1o), was synthesized and its photochromic and fluorescent properties were investigated. The product has been characterized by elemental analyses, NMR spectrometry, UV/vis spectrophotometry and Fluorescence spectrophotometry. This diarylethene exhibited reversible photochromism and notable fluorescence photoswitches both in solution and in PMMA films, changing from colorless to pink after irradiation with 297 nm UV light. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9HPLC of Formula: 10243-15-9).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is also used in the manufacturing of dyes such as thioindigo.HPLC of Formula: 10243-15-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Photodeoxygenation of dinaphthothiophene, benzophenanthrothiophene, and benzonaphthothiophene S-oxides was written by Zheng, X.;Baumann, S. M.;Chintala, S. M.;Galloway, K. D.;Slaughter, J. B.;McCulla, R. D.. And the article was included in Photochemical & Photobiological Sciences in 2016.HPLC of Formula: 6287-82-7 This article mentions the following:

The sulfoxides benzo[b]naphtho-[1,2,d]thiophene S-oxide, benzo[b]naphtho[2,1,d]thiophene S-oxide, benzo[b]phenanthro[9,10-d]thiophene S-oxide, dinaphtho[2,1-b:1′,2′-d]thiophene S-oxide, and dinaphtho[1,2-b:2′,1′-d]thiophene S-oxide all absorb light at longer wavelengths than DBTO. To determine if these sulfoxides could be used to generate O(³P), quantum yield studies, product studies, and computational anal. were performed. Quantum yields for the deoxygenation were up to 3 times larger for these sulfoxides compared to DBTO. However, oxidation of the solvent by these sulfoxides resulted in different ratios of oxidized products compared to DBTO, which suggested a change in deoxygenation mechanism. D. functional calculations revealed a much larger singlet-triplet gap for the larger sulfoxides compared to DBTO. This led to the conclusion that the examined sulfoxides could undergo deoxygenation by two different mechanisms. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7HPLC of Formula: 6287-82-7).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.HPLC of Formula: 6287-82-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem