Category: benzothiophene

5-Substituted Benzothiophenes: Synthesis, Mechanism, and Kinetic Studies was written by Cerminara, Iole;D’Alessio, Luciano;D’Auria, Maurizio;Funicello, Maria;Guarnaccio, Ambra. And the article was included in Helvetica Chimica Acta in 2016.Name: 6-Methoxybenzo[b]thiophene This article mentions the following:

The kinetics of the reaction of 4-methoxythiophenoxyacetaldehyde di-Et acetal, 4-nitrothiophenoxyacetaldehyde di-Et acetal, and 3-methoxythiophenoxyacetaldehyde di-Et acetal in polyphosphoric acid was explained. The kinetic behavior was explained from aided simulation and from d. functional theory calculations showing a different pathway for 4-nitrothiophenoxyacetaldehyde di-Et acetal and for 4-methoxythiophenoxyacetaldehyde di-Et acetal. In this last case, a very fast competing reaction to the dimerization product was observed In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Name: 6-Methoxybenzo[b]thiophene).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Name: 6-Methoxybenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A Transition-Metal-Free One-Pot Cascade Process for Transformation of Primary Alcohols (RCH₂OH) to Nitriles (RCN) Mediated by SO₂F₂ was written by Jiang, Ying;Sun, Bing;Fang, Wan-Yin;Qin, Hua-Li. And the article was included in European Journal of Organic Chemistry in 2019.Computed Properties of C9H5NS This article mentions the following:

Primary (benzylic) alcs. underwent transition-metal-free one-pot cascade process with SO₂F₂, K₂CO₃, and NH₂OH·HCl in DMSO to yield nitriles without introducing an addnl. carbon atom. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Computed Properties of C9H5NS).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Computed Properties of C9H5NS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis, properties and optical recording of a novel unsymmetrical photochromic diarylethene was written by Wang, Liqin;Pu, Shouzhi;Yan, Liushui;Cui, Shiqiang. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2011.SDS of cas: 10243-15-9 This article mentions the following:

A new unsym. photochromic diarylethene, 1-(2-methyl-3-benzothienyl)-2-(2-butyl-5-methylol-3-thienyl)perfluorocyclopentene (1a), was synthesized and its photochromism and fluorescence were studied in in solution and in poly(Me methacrylate) (PMMA) amorphous films. Polarization multiplexed image recording was carried out using closed-form of 1a in PMMA film and linearly polarized 633 nm laser diode for recording/readout. The diarylethene can be potentially used as holog. optical recording medium. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9SDS of cas: 10243-15-9).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.SDS of cas: 10243-15-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Well-Defined Palladium N-Heterocyclic Carbene Complexes: Direct C-H Bond Arylation of Heteroarenes was written by Kumar, Anuj;Kumar, Manoj;Verma, Akhilesh K.. And the article was included in Journal of Organic Chemistry in 2020.Recommanded Product: 90560-10-4 This article mentions the following:

A series of palladium N-heterocyclic carbene (NHC) complexes of type trans-{(NHC)PdCl₂L} (L = C₅H₅N, 3-ClC₅H₄N, and PPh₃) have been developed as efficient precatalysts for direct C-H bond arylation of various heteroarenes. In particular, an in situ generated new NHC ligand derived from {1,3-bis(2,6-diethylphenyl)acenaphtho[1,2-d]imidazolium} chloride is used for the stabilization of the palladium metal center. Among the screened palladium precatalysts, the most active PEPPSI themed complex was successfully employed toward direct C-H bond arylation of various heteroarenes and aryl bromides. A range of functional groups on aryl bromides as well as on heteroarenes sustained throughout the standard reaction conditions for easy access of various arylated heterocyclic compounds Significantly, the utility of the protocol was demonstrated by the effective synthesis of a precursor of raloxifene, a selective estrogen receptor modulator. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Recommanded Product: 90560-10-4).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Recommanded Product: 90560-10-4

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

V-shaped thiophene-based oligomers with improved electroluminescence properties was written by Barbarella, Giovanna;Favaretto, Laura;Zanelli, Alberto;Gigli, Giuseppe;Mazzeo, Marco;Anni, Marco;Bongini, Alessandro. And the article was included in Advanced Functional Materials in 2005.SDS of cas: 6287-82-7 This article mentions the following:

The synthesis via the Stille coupling of a new family of oligomers derived from benzo[b]thiophene is reported. Owing to their branched mol. structure lacking any symmetry element, these compounds display a low tendency to crystallization and better film-forming properties than their linear counterparts. Spin-coated films show photoluminescence efficiencies up to 50%. Light-emitting diodes with spin-coated films as the active layers display markedly improved performance with respect to similar devices based on linear oligothiophenes, with luminance values up to more than 10 000 cd m^-2. Semiempirical PM3 and ZINDO/S calculations provide insight into the mol. geometries and electron distribution of the frontier orbitals of the new compounds Cyclic voltammetry data indicates that the transformation of the thienyl sulfur of benzo[b]thiophene to the corresponding thienyl-S,S-dioxide leads an increase in electron affinity by 0.5-0.7 V, analogous to that of the corresponding linear oligomers. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7SDS of cas: 6287-82-7).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.SDS of cas: 6287-82-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Dual Gold Catalysis: Bidirectional Processes and Tandem sp³-C-H Insertion Reactions was written by Tsupova, Svetlana;Rudolph, Matthias;Rominger, Frank;Hashmi, A. Stephen K.. And the article was included in Chemistry – A European Journal in 2017.Synthetic Route of C8H4Br2S This article mentions the following:

Various tetrayne systems were converted under dual gold-catalyzed conditions. For sym. tetraalkynyl-substituted thiophenes, bearing two alkyl-substituted alkynes and two terminal alkyne units, bidirectional cyclizations led to the efficient formation of dibenzothiophene systems. In all cases, selective C-H activation of the C-H bond of the alkyl substituent was observed leading to cyclopentane moieties annelated to the newly formed aromatic cores. If two thiophene moieties were tethered over the attached non-terminal alkynes, depending on the length of the connecting alkyl tether, either bidirectional processes or tandem processes can be addressed leading to interesting mol. structures, such as spiro compounds or isolated benzothiophenes connected by a C-C bond. Other electron-rich heterocycles also reacted. While the reactions even worked for some mixed systems, other cases only delivered the products of a mono-cyclization. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Synthetic Route of C8H4Br2S).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Synthetic Route of C8H4Br2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity was written by Graham, Samuel L.;Shepard, Kenneth L.;Anderson, Paul S.;Baldwin, John J.;Best, Darryl B.;Christy, Marcia E.;Freedman, Mark B.;Gautheron, Pierre;Habecker, Charles N.. And the article was included in Journal of Medicinal Chemistry in 1989.Product Details of 90560-10-4 This article mentions the following:

Derivatives of 2-benzo[b]thiophenesulfonamide were prepared to investigate their utility as topically active inhibitors of ocular carbonic anhydrase for treating glaucoma. Among the compounds described are 6-hydroxy-2-benzo[b]thiophenesulfonamide and its acetate, which are among the most potent ocular hypotensives in this class, as assessed in the α-chymotrypsinized rabbit. These compounds were selected for clin. evaluation. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Product Details of 90560-10-4).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Product Details of 90560-10-4

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Efficient synthesis of 3-oxygenated benzothiophene derivatives was written by Zhang, Fuyao;Mitchell, David;Pollock, Patrick;Zhang, Tony Y.. And the article was included in Tetrahedron Letters in 2007.Reference of 90560-10-4 This article mentions the following:

An efficient synthesis of 2-bromo-3-(aryloxy)benzothiophene derivatives by a conjugate addition-elimination sequence of 2,3-dibromobenzothiophene dioxides with phenolic nucleophiles was developed. These benzothiophene derivatives serve as important intermediates for the synthesis of SERM (selective estrogen receptor modulator) analogs. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Reference of 90560-10-4).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Reference of 90560-10-4

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Photochromic dihetarylethenes. 10. Photochromic 1,2-bis[2-(benzothiazol-2-yl)-3-thienyl]- and 1,2-bis[2-(benzothiazol-2-yl)benzothiophen-3-yl]ethenes was written by Krayushkin, M. M.;Stoyanovich, F. M.;Zolotarskaya, O. Yu.;Murav’ev, I. V.;Martynkin, A. Yu.;Uzhinov, B. M.. And the article was included in Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) in 2001.SDS of cas: 6287-82-7 This article mentions the following:

1,2-Di(thien-3-yl)ethenes containing thiophene rings with benzothiazolyl substituents in position 2 were synthesized. 1,2-Bis[2-(benzothiazol-2-yl)benzothiophen-3-yl]hexafluorocyclopentene and 1,2-bis[2,5-di(benzothiazol-2-yl)-3-thienyl]hexafluorocyclopentene possess photochromic properties. The open forms of 1,2-bis(2-benzothiazolylhetaryl)ethenes fluoresce, but introduction of the benzothiazole rings into dihetarylethenes significantly lowers the fatigue resistance of photochromes and favors thermal reversibility. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7SDS of cas: 6287-82-7).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.SDS of cas: 6287-82-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Small-Molecule Inhibitors of the TLR3/dsRNA Complex was written by Cheng, Kui;Wang, Xiaohui;Yin, Hang. And the article was included in Journal of the American Chemical Society in 2011.Application of 70060-13-8 This article mentions the following:

The protein-RNA interface has been regarded as “undruggable” despite its importance in many biol. processes. The toll-like receptor 3 (TLR3)/double-stranded RNA (dsRNA) complex provides an exciting target for a number of infectious diseases and cancers. We describe the development of a series of small-mol. probes that were shown to be competitive inhibitors of dsRNA binding to TLR3 with high affinity and specificity. In a multitude of assays, compound 4a was profiled as a potent antagonist to TLR3 signaling and also repressed the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β. In the experiment, the researchers used many compounds, for example, 5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8Application of 70060-13-8).

5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Application of 70060-13-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem