Category: benzothiophene

Synthetic Route of 16587-47-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.16587-47-6, Name is 6-Methylbenzo[b]thiophene, molecular formula is C9H8S. In a article£¬once mentioned of 16587-47-6

Application of directed metalation in synthesis. Part 4: Expedient synthesis of substituted benzo[b]thiophene and naphthothiophene

A short, simple and inexpensive synthesis of several diversely substituted benzo[b]thiophenes and one naphthothiophene is described. The method involves introduction of methylsulfanyl group ortho- to the amide function of readily available N,N-diethylamides of aryl carboxylic acid by directed metalation. Thioindoxyls, obtained in high yields through side-chain deprotonation and cyclisation in one pot, are reduced to benzo[b]thiophene or napthothiophene.

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Benzothiophene | C8H6S – PubChem

 

Related Products of 22913-24-2, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 22913-24-2, Name is Methyl benzo[b]thiophene-2-carboxylate, molecular formula is C10H8O2S. In a Article£¬once mentioned of 22913-24-2

Benzo[b]thiophene-2-carboxamide derivatives as potent urotensin-II receptor antagonists

Members of a series of benzo[b]thiophene-2-carboxamide derivatives, possessing an N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)piperidin-4-yl) group, were synthesized and evaluated as urotensin-II receptor antagonists. The results show that these substances have potent UT binding affinities. Observations made in a systematic SAR investigation of the effects of a variety of substituents (R1and R2) at the 5- and 6-positions in the benzo[b]thiophene-2-carboxamide moiety on UT binding affinities led to identification of the 5-cyano analog 7f as a highly potent UT antagonist with an IC50value of 25?nM. Despite having a good metabolic stability, 7f is a potent inhibitor of CYP isozyme and displays an unsuitable PK profile.

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346592-74-3, Name is 7-Fluorobenzo[b]thiophene, belongs to benzothiophene compound, is a common compound. Safety of 7-Fluorobenzo[b]thiopheneIn an article, once mentioned the new application about 346592-74-3.

USE OF HISTONE DEACETYLASE INHIBITORS FOR THE CARE OF PHILADELPHIA-NEGATIVE MYELOPROLIFERATIVE SYNDROMES

The use of substances capable of inhibiting one or more enzymes of the histone deacetylase family (histone deacetylase inhibitors) for the therapeutic treatment of Philadelphia-negative myeloproliferative syndromes (polyeythemia vera, essential thrombocythemia or idiopathic myelotibrosis) is described. The dosage of the above-mentioned substances is significantly lower than that normally used for the care of other tumour syndromes and may be from 10 to 150 mg/day/patient.

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Related Products of 26018-73-5, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 26018-73-5, Name is 6-Chlorobenzo[b]thiophene-2-carboxylic acid,introducing its new discovery.

Design, synthesis, and structure-activity and structure-pharmacokinetic relationship studies of novel [6,6,5] tricyclic fused oxazolidinones leading to the discovery of a potent, selective, and orally bioavailable FXa inhibitor

The blood coagulation enzyme factor Xa (FXa) is a particularly promising target for anticoagulant therapy, and identification of oral small-molecule inhibitors of FXa remains a research focus. On the basis of the X-ray crystal structure of FXa and its inhibitor rivaroxaban, we designed and synthesized a series of conformationally restricted mimics containing a novel [6,6,5] tricyclic fused oxazolidinone scaffold. Intensive structure-activity relationship (SAR) and structure-pharmacokinetic relationship (SPR) studies on this new series led to the discovery of compound 11a: a highly potent, selective, direct, and orally bioavailable FXa inhibitor with excellent in vivo antithrombotic efficacy and preferable pharmacokinetic profiles. Druggability evaluation of compound 11a was undertaken and elicited positive outcomes. All results indicate that compound 11a is a promising drug candidate for the prevention and treatment of thromboembolic diseases in venous and arterial systems.

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Related Products of 360575-29-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 360575-29-7, Name is Methyl 4-bromobenzo[b]thiophene-2-carboxylate, molecular formula is C10H7BrO2S. In a Article£¬once mentioned of 360575-29-7

Spirolactam-based acetyl-CoA carboxylase inhibitors: Toward improved metabolic stability of a chromanone lead structure

Acetyl-CoA carboxylase (ACC) catalyzes the rate-determining step in de novo lipogenesis and plays a crucial role in the regulation of fatty acid oxidation. Alterations in lipid metabolism are believed to contribute to insulin resistance; thus inhibition of ACC offers a promising option for intervention in type 2 diabetes mellitus. Herein we disclose a series of ACC inhibitors based on a spirocyclic pyrazololactam core. The lactam series has improved chemical and metabolic stability relative to our previously reported pyrazoloketone series, while retaining potent inhibition of ACC1 and ACC2. Optimization of the pyrazole and amide substituents led to quinoline amide 21, which was advanced to preclinical development.

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Synthetic Route of 63675-74-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 63675-74-1, Name is 6-Methoxy-2-(4-methoxyphenyl)-1-benzothiophene, molecular formula is C16H14O2S. In a Patent£¬once mentioned of 63675-74-1

Glucopyranoside benzothiophenes

A compound of the formula STR1 or a pharmaceutically acceptable salt or solvate thereof. Also provided by the invention are methods of use of the above compounds, and processes for the preparation thereof.

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 84449-65-0, name is 4-(6-((Methylsulfonyl)oxy)benzo[b]thiophen-2-yl)phenyl methanesulfonate, introducing its new discovery. Safety of 4-(6-((Methylsulfonyl)oxy)benzo[b]thiophen-2-yl)phenyl methanesulfonate

Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes

The use of particularly advantageous protecting groups for the hydroxy groups of 6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophenes provides a high-yielding process for the preparation of such compounds having a 4-(2-aminoethoxy)benzoyl 3-group.

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 4923-87-9, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 4923-87-9, name is 5-Bromobenzothiophene. In an article£¬Which mentioned a new discovery about 4923-87-9

Self-assembly, physicochemical, and field-effect transistor properties of solution-crystallized organic semiconductors based on pi-extended dithieno[3,2-b:2?,3?-d]thiophenes

Thienoacene-based pi-conjugated oligomers, DTT-NP8 and DTT-BT8, were designed and synthesized. Their strong intermolecular interactions originating from S…S contacts enable the fabrication of single-crystal microribbons via solution processing. Organic single-crystal transistors exhibited field-effect mobilities as high as 0.54 cm2V-1 s -1 and on/off current ratio of ca. 106.

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Chemistry is traditionally divided into organic and inorganic chemistry. name: 6-Methoxy-2-(4-methoxyphenyl)-1-benzothiophene, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 63675-74-1

Methods of use for inhibiting bone loss and lowering serum cholesterol

A method of inhibiting bone loss or resorption, or lowering serum cholesterol, comprising administering to a human in need thereof a compound having the formula STR1 or a pharmaceutically acceptable salt or solvate thereof, in a low dosage amount. Also encompased by the invention is a a pharmaceutical formulation in unit dosage form comprising, per unit dosage, a low dosage amount.

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Synthetic Route of 130-03-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.130-03-0, Name is Benzo[b]thiophen-3(2H)-one, molecular formula is C8H6OS. In a Article£¬once mentioned of 130-03-0

THE TAUTOMERISM OF HYDROXY DERIVATIVES OF FIVE-MEMBERED OXYGEN, NIRTOGEN, AND SULFUR HETEROCYCLES

The unstable enolic tautomers 3-hydroxyfuran, 2- and 3-hydroxy-thiophene, 3-hydroxy-pyrrole, 3-hydroxy-1-methyl-pyrrole and their benzo-derivatives have been generated in solution and the rate and equilibrium constants for their ketoization determined.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem