Category: benzothiophene

Extended knowledge of 2-Bromobenzo[b]thiophene

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New synthesis of aryl and heteroaryl N-acylureas via microwave-assisted palladium-catalysed carbonylation

A new, practical synthesis of aryl and heteroaryl N-acylureas has been developed via palladium-catalysed carbonylation of aryl or heteroaryl halides in the presence of urea nucleophiles. A range of reactions illustrating the wide scope of this reaction was carried out under microwave irradiation, using either carbon monoxide gas in a vessel equipped with a gas inlet adapter, or molybdenum hexacarbonyl as the carbon monoxide source in standard microwave vials. The reactions proceeded in good to excellent yields. To illustrate the usefulness of this method a one-step synthesis of the important insecticide diflubenzuron is reported.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Some scientific research about 130-03-0

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, SDS of cas: 130-03-0, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 130-03-0, Name is Benzo[b]thiophen-3(2H)-one, molecular formula is C8H6OS

gamma-Radiolysis of Aqueous Benzothiophene Solutions

gamma-Radiolysis of aqueous benzothiophene solutions saturated with N2O has been studied.In the absence of other reagents, the only products detected are 2- and 3-hydroxybenzothiophene and their corresponding lactonic and ketonic tautomers and a small amount of dimeric species.In the presence of potassium hexacyanoferrate or sodium hydroxide, however, products attributable to hydroxylation at all six available carbon sites are detected and dimer formation is reduced.Analysis of the experimental data suggests that both benzothiophene and its hydroxylation products are efficient scavengers for the radiation-produced OH radicals and that the initial yield of hydroxylation products is equal to that of hydroxyl radicals.Consistent with the electrophilic characteristics of the OH radical, k(OH+C8H6S):k(OH+C8H5SOH)=0.5+/-0.1.All six available carbon sites are capable of forming OH adducts, but the radicals formed by addition to the 4, 5, 6, and 7 positions tend to revert to the original compound or its ion in a neutral or acidic medium.In the case of the adducts formed by addition to the thiophene ring, on the other hand, the 3 position is seen to be favored, possibly as the result of the preservation of the aromatic benzene resonance structure.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Awesome Chemistry Experiments For 3-Bromo-2-methylbenzo[b]thiophene

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COLD MENTHOL RECEPTOR-1 ANTAGONISTS

The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.

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New explortion of 10134-95-9

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 10134-95-9, name is Benzo[b]thiophene-4-carboxylic acid, introducing its new discovery. Quality Control of Benzo[b]thiophene-4-carboxylic acid

Application of Bivalent Bioisostere Concept on Design and Discovery of Potent Opioid Receptor Modulators

Here, we described the structural modification of previously identified mu opioid receptor (MOR) antagonist NAN, a 6alpha-N-7?-indolyl substituted naltrexamine derivative, and its 6beta-N-2?-indolyl substituted analogue INTA by adopting the concept of “bivalent bioisostere”. Three newly prepared opioid ligands, 25 (NBF), 31, and 38, were identified as potent MOR antagonists both in vitro and in vivo. Moreover, these three compounds significantly antagonized DAMGO-induced intracellular calcium flux and displayed varying degrees of inhibition on cAMP production. Furthermore, NBF produced much less significant withdrawal effects than naloxone in morphine-pelleted mice. Molecular modeling studies revealed that these bivalent bioisosteres may adopt similar binding modes in the MOR and the “address” portions of them may have negative or positive allosteric modulation effects on the function of their “message” portions compared with NAN and INTA. Collectively, our successful application of the “bivalent bioisostere concept” identified a promising lead to develop novel therapeutic agents toward opioid use disorder treatments.

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The Absolute Best Science Experiment for 4-Methylbenzo[b]thiophene

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Adsorption structures of heterocyclic sulfur compounds on Cu(I)Y zeolite: a first principle study

The adsorption configurations of benzothiophene (BT), dibenzothiophene (DBT) molecules and their derivatives, 4-methylbenzothiophene (4-MBT) and 4,6-dimethyl dibenzothiophene (4,6-DMDBT), on a Cu(I)Y zeolite were studied by using a density functional theory (DFT) method. The eta2 adsorption mode through the C=C bond of the thiophenic ring on the zeolite has been found to be energetically preferred for the BTs, abundant in gasoline, while for the DBTs, mainly available in diesel fuel, the eta1S adsorption mode is the most preferential one, implying that the competitive adsorption of aromatics over S-compounds is stronger in gasoline than that in diesel fuels. These results can be ascribed to the difference in the aromaticity and the molecular features of the heterocyclic sulfur compounds.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Properties and Exciting Facts About 5394-13-8

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Intramolecular cross-coupling of gem-dibromoolefins: A mild approach to 2-bromo benzofused heterocycles

Highly useful halogenated benzofurans and benzothiophenes are prepared from readily available gem-dibromoolefins using a mild, ligand-free copper catalyzed cross-coupling procedure.

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Awesome Chemistry Experiments For 3-(Bromomethyl)-5-chlorobenzo[b]thiophene

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ANTIDIABETIC COMPOUNDS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

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Benzothiophene – Wikipedia,
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Awesome Chemistry Experiments For 310466-38-7

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Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 2

Potent 5-HT1A/SSRIs at low nanomolar and subnanomolar concentrations were identified in a series of 1-(1H-indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols. Incorporation of an alpha-Me group in the piperidine ring with its specific stereochemistry enhanced binding affinity at the 5-HT reuptake site and in vitro 5-HT1A antagonist functional activity.

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Benzothiophene | C8H6S – PubChem

 

Top Picks: new discover of 5394-13-8

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5394-13-8, Name is 2-Bromobenzo[b]thiophene, belongs to benzothiophene compound, is a common compound. Recommanded Product: 5394-13-8In an article, once mentioned the new application about 5394-13-8.

Dual fluorescent deoxyguanosine mimics for FRET detection of G-quadruplex folding

Replacement of deoxyguanosine (dG) nucleobases within G-tetrads of G-quadruplex folding oligonucleotides with donor (D)/acceptor (A) fluorescent 8aryldG residues provides diagnostic FRET signalling for G-quadruplex detection.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Extracurricular laboratory:new discovery of 5394-13-8

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Electric Literature of 5394-13-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.5394-13-8, Name is 2-Bromobenzo[b]thiophene, molecular formula is C8H5BrS. In a article£¬once mentioned of 5394-13-8

Late Stage Functionalization of Secondary Amines via a Cobalt-Catalyzed Electrophilic Amination of Organozinc Reagents

A general preparation of polyfunctional hydroxylamine benzoates from the corresponding secondary amines is reported. This convenient synthesis allows the setup of a late-stage functionalization of various secondary amines, including pharmaceuticals and peptidic derivatives. Thus, a cross-coupling of hydroxylamine benzoates with various alkyl-, aryl-, and heteroaryl-zinc chlorides in the presence of 5 mol % CoCl2 (25 C, 2 h) provides a range of polyfunctional tertiary amines. This method was used to prepare penfluridol and gepirone.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem