Category: benzothiophene

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Galenko, Ekaterina E. and a compound is mentioned, 22913-24-2, Methyl benzo[b]thiophene-2-carboxylate, introducing its new discovery. 22913-24-2

Synthesis and Intramolecular Azo Coupling of 4-Diazopyrrole-2-carboxylates: Selective Approach to Benzo and Hetero [c]-Fused 6H-Pyrrolo[3,4-c]pyridazine-5-carboxylates

A high yield synthesis of fluorescent benzo, thieno, and furo [c]-fused methyl 7-aryl-6H-pyrrolo[3,4-c]pyridazine-5-carboxylates, including unprecedented heterocyclic skeletons, was performed by the transformation of methyl 4-aminopyrrole-2-carboxylate into the corresponding diazo compound, followed by intramolecular azo coupling under acid conditions onto a nucleophilic aryl or hetaryl group in the 3-position. Azo coupling is completely regioselective and, according to DFT calculations, a kinetically controlled reaction. N-Methylation of 1,3-disubstituted 2H-pyrrolo[3,4-c]cinnolines occurs selectively at N5 under kinetic control, leading exclusively to 5-methyl-5H-pyrrolo[3,4-c]cinnoline derivatives.

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35212-85-2, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 35212-85-2, name is Methyl 3-aminobenzo[b]thiophene-2-carboxylate, introducing its new discovery.

A red phosphorescent compound and its use the organic light-emitting device (by machine translation)

The invention relates to a red phosphorescent compounds and the use of the compounds of the organic light emitting device, more specifically, relates to a has excellent color purity and high brightness and light-emitting efficiency of the soluble phosphorescent compounds and the use of the compounds of the OLED device. A phosphorescent compounds, as shown in structural formula I, In the above formula I, Z is independently selected from the following structure: Wherein Ar independently selected from C6 – C30 aryl, C2 – C30 heteroaryl in a. The C6 – C30 aryl group selected from phenyl, naphthyl, biphenylyl, terphenylyl and phenanthrene-one. The C2 – C30 heteroaryl selected from pyridyl, linked pyridyl, quinolyl, isoquinolyl, phenanthroline-based and triazine-based one. This invention uses the I as shown in the chemical formula of the organic light emitting diode device of the luminescent layer, has excellent color purity and brightness and the effect of the extension of the durability. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.35212-85-2, you can also check out more blogs about35212-85-2

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6287-82-7, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 6287-82-7, name is 2,3-Dibromobenzo[b]thiophene. In an article£¬Which mentioned a new discovery about 6287-82-7

Highly emissive B?N unit containing four-coordinate C,N-Chelated organoboron compound for the detection of fluoride ions

The highly emissive B?N unit containing four-coordinate C,N-chelated organoboron compound, 2 was synthesized. This air and moisture stable compound can be used as a turn-off type fluorescent fluoride (F?) sensor in THF with good selectivity and reversibility. The DFT calculation and the fluorescence quenching titration results showed that the mechanism of the sensing process was based on a competing reaction: the formation of 2-F with the stronger B[sbnd]F bond in an open form took the place of 2 with B?N bond in a closed form when F? was introduced, leading to significant absorption changing and fluorescence quenching.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 6287-82-7 is helpful to your research. 6287-82-7

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4923-87-9, name is 5-Bromobenzothiophene, introducing its new discovery. 4923-87-9

Palladium-catalyzed direct C(sp3)-H arylation of indole-3-ones with aryl halides: A novel and efficient method for the synthesis of nucleophilic 2-monoarylated indole-3-ones

A novel and efficient method for the synthesis of nucleophilic 2-monoarylated indole-3-ones via palladium-catalyzed direct C(sp3)-H arylation of indole-3-ones with aryl halides has been developed. Various 2-monoarylated indole-3-ones were readily obtained with yields up to 95%. As a class of important nucleophilic intermediates, 2-monoarylated indole-3-ones can be used for the construction of C2-quaternary indolin-3-one skeletons.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4923-87-9 is helpful to your research. 4923-87-9

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17402-83-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 17402-83-4, molecular formula is C8H7NS, introducing its new discovery.

Herbicides

The invention provides certain herbicidal thiazolotriazole sulphonamides, processes for their preparation, and compositions containing them, the compounds being of the formula: STR1 where: R1 and R2, which may be the same or different, each represent hydrogen, hydroxy, halo, cyano, substituted or unsubstituted alkyl, alkoxy, alkenyloxy, alkynyloxy, aryl, aralkyl, heteroaryl or carbamoyl, or a group –CORa or –CO2 Ra or where Ra is hydrogen or alkyl; or R1 and R2 together represent an alkylene chain of 3 or 4 carbon atoms; R3 represents a substituted or unsubstituted aryl, heterocyclyl or benzheterocyclyl group; and R4 represents hydrogen, an alkali-metal atom, an ammonium group, a substituted or unsubstituted alkyl, alkenyl, alkynyl, acyl, alkoxycarbonyl or aralkyl group, a heterocyclic group, or a group of the formula: STR2 where R1 and R2 are as defined hereinbefore.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.17402-83-4, you can also check out more blogs about17402-83-4

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Benzothiophene | C8H6S – PubChem

 

130-03-0, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 130-03-0, Name is Benzo[b]thiophen-3(2H)-one, molecular formula is C8H6OS. In a Article, authors is Morizur, Vincent£¬once mentioned of 130-03-0

Catalysis of the acylation of aromatic derivatives by metallic tosylates

A series of metallic tosylates were prepared by ultrasonic metal activation and were further used as efficient catalysts for the acylation of aromatic derivatives.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. 130-03-0, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 130-03-0, in my other articles.

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Chemistry is traditionally divided into organic and inorganic chemistry. 20503-40-6, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 20503-40-6

STAT3 INHIBITOR

Provided are STAT3 inhibitors and methods of treating inflammation or a hyperproliferative disease such as, e.g., cancer. In some aspects, compounds may be used to treat breast cancer, a head/neck cancer, a lung cancer, a prostate cancer, or pancreatic cancer.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 20503-40-6, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 20503-40-6

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Benzothiophene – Wikipedia,
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360575-29-7, An article , which mentions 360575-29-7, molecular formula is C10H7BrO2S. The compound – Methyl 4-bromobenzo[b]thiophene-2-carboxylate played an important role in people’s production and life.

Rational drug design of indazole-based diarylurea derivatives as anticancer agents

A series of novel indazole-based diarylurea derivatives targeting c-kit were designed by structure-based drug design. The derivatives were prepared, and their antiproliferative activities were evaluated against human colon cancer HCT-116 cell line and hepatocellular carcinoma PLC/PRF/5 cell line. The antiproliferative activities demonstrated that six of nine compounds exhibited comparable activities with sorafenib against HCT-116. The structure?activity relationship (SAR) analysis indicated that the indazole ring part tolerated different kinds of substituents, and the N position of the central pyridine ring played key roles in antiproliferative activity. The SAR and interaction mechanisms were further explored using molecular docking method. Compound 1i with N-(2-(pyrrolidin-1-yl)ethyl)-carboxamide possessed improved solubility, 596.1?ng/ml and best activities, IC50 at 1.0?mum against HCT-116, and 3.48?mum against PLC/PRF/5. It is a promising anticancer agent for further development.

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Benzothiophene – Wikipedia,
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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 4923-87-9, In a patent£¬Which mentioned a new discovery about 4923-87-9

Dihydroimidazo[2,1-b]thiazole and dihydro-5h-thiazolo[3,2-A]pyrimidines as antidepressant agents

The present invention relates to certain novel substituted dihydroimidazo[2,1-b]thiazole and dihydro-5H-thiazolo[3,2-a]pyrimidine compounds of Formula (I) including pharmaceutically acceptable salts thereof in which have affinity for 5-HT1A receptors and which inhibits neuronal reuptake of 5-hydroxytryptamine and/or noradrenaline, to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of depression, anxiety, psychoses (for example schizophrenia), tardive dyskinesia, obesity, drug addiction, drug abuse, cognitive disorders, Alzheimer’s disease, obsessive-compulsive behaviour, panic attacks, social phobias, eating disorders such as bulimia, anorexia, snacking and binge eating, non-insulin dependent diabetes mellitus, hyperglycaemia, hyperlipidaemia, stress, as an aid to smoking cessation and in the treatment and/or prophylaxis of seizures, neurological disorders such as epilepsy and/or in which there is neurological damage such as stroke, brain trauma, cerebral ischaemia, head injuries and haemorrhage.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 4923-87-9, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 4923-87-9

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. 360575-29-7. Introducing a new discovery about 360575-29-7, Name is Methyl 4-bromobenzo[b]thiophene-2-carboxylate

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides

TTK kinase was identified by in-house siRNA screen and pursued as a tractable, novel target for cancer treatment. A screening campaign and systematic optimization, supported by computer modeling led to an indazole core with key sulfamoylphenyl and acetamido moieties at positions 3 and 5, respectively, establishing a novel chemical class culminating in identification of 72 (CFI-400936). This potent inhibitor of TTK (IC50 = 3.6 nM) demonstrated good activity in cell based assay and selectivity against a panel of human kinases. A co-complex TTK X-ray crystal structure and results of a xenograft study with TTK inhibitors from this class are described.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem