The Absolute Best Science Experiment for Benzo[b]thiophen-4-amine

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In an article, published in an article,authors is Bonini, Carlo, once mentioned the application of 17402-83-4, Name is Benzo[b]thiophen-4-amine,molecular formula is C8H7NS, is a conventional compound. this article was the specific content is as follows. 17402-83-4

Smiles rearrangement for the synthesis of 5-amino-substituted [1]benzothieno[2,3-b]pyridine

The Smiles rearrangement was successfully applied to 4-hydroxybenzo[b]thiophene furnishing a facile entry to the 4-amino derivative. The rearrangement was extended to 5-methoxy-4-methoxycarbonyl[1]benzothieno[2,3-b]pyridine obtained via aza-Wittig/electrocyclization reaction of novel N-(4-methoxybenzothiophen-2-yl)iminomethyldiphenylphosphorane with methyl trans-4-oxo-2-pentenoate. The preparation of a novel 5-amino-4-methoxycarbonyl[1]benzothieno[2,3-b]pyridine, which is of interest as a potential secondary peptide structure mimic, was successfully achieved.

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Awesome Chemistry Experiments For 6287-82-7

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 6287-82-7

6287-82-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.6287-82-7, Name is 2,3-Dibromobenzo[b]thiophene, molecular formula is C8H4Br2S. In a Article, authors is Salman, Ghazwan Ali£¬once mentioned of 6287-82-7

Domino C-N coupling/annulation versus C-N coupling/ hydroamination of 2-alkynyl-3-bromobenzothiophenes and 2-alkynyl-3-bromothiophenes. highly efficient synthesis of benzothieno[3,2-b]quinolines and thieno[3,2-b]pyrroles

While the palladium-catalyzed reaction of 2-alkynyl-3-bromothiophenes with anilines afforded thienopyrroles by a domino C-N coupling/hydroamination process, the reaction of 2-alkynyl-3-bromobenzothiophenes with anilines resulted, under identical conditions, in the formation of benzothienoquinolines by a domino C-N coupling/annulation process. The electronic character of the aniline also has an influence on the product distribution.

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A new application about 6287-82-7

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Thermally-stable 2,3-diphenylated benzotiophene containing host materials for red phosphorescent organic light-emitting diodes

This study reports a series of benzo[b]thiophene (BT) derivatives with good electronic properties as host materials for red phosphorescent organic light-emitting diodes (PHOLEDs). We applied thermally-stable materials for red PHOLEDs which contain BT and carbazole moieties which also provide a good charge transport ability, as well as a good charge confinement effect (T1 > 2.25 eV). To control the appropriate charge transporting ability, two different structures having one or two carbazole units connected to the single BT moiety were prepared. Using this approach, we found that the material with a single carbazole and a single BT unit showed the best current efficiency and external quantum efficiency (up to 23.6 cd/A and 12.8%, respectively). The results of the experiment also suggest that BT could be used as an electron-transporting unit when utilized with carbazole moiety, although it has previously been utilized as a p-type material.

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New explortion of 5-Bromobenzothiophene

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Halogenated fluorine-containing zinc compound alkenylsilane (cyclometallized) (by machine translation)

The purpose of the present invention is to provide a method for easily producing a fluorine-containing (cyclo)alkenyl zinc halide compound at low cost. The present invention provides a method for producing a fluorine-containing (cyclo)alkenyl zinc halide compound represented by formula (1) (wherein A1 represents a perfluoroalkyl group having 1-12 carbon atoms, or a fluorine atom; A2 represents a fluorine atom or a hydrogen atom; A3 represents a fluorine atom or a hydrogen atom, or alternatively A3 and A1 or A2 may combine together to form a perfluoroalkylene chain having 1-12 carbon atoms; and X’ represents a halogen atom), which comprises a step wherein a fluorine-containing olefin represented by formula (2) (wherein X” represents a fluorine atom or a chlorine atom; and the other symbols are as defined above) is reacted with a zinc halide represented by formula ZnX’2 (wherein the symbol is as defined above) in the presence of one or more metals that are selected from among magnesium and magnesium alloys.

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Extracurricular laboratory:new discovery of 360575-29-7

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360575-29-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 360575-29-7, molcular formula is C10H7BrO2S, introducing its new discovery.

SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS

The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.

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Analyzing the synthesis route of 6314-28-9

6314-28-9 Benzo[b]thiophene-2-carboxylic acid 95864, abenzothiophene compound, is more and more widely used in various fields.

6314-28-9,6314-28-9, Benzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Benzo [b] thiophene-2-carboxylic acid (159 mg, 0.892 mmol), 2-amino-biphenyl (156 mg, 0.922 mmol), DCC (393 mg, 1.90mmol) and DMAP (26 mg, 0.21 mmol) It was dissolved in dichloromethane (20 mL), and stirred for 14 hours at room temperature. when thin layer chromatography (TLC) check when, a new spot is generated, and then adding water to the reaction mixture, dichloromethane comingAnd extracted twice with. The extracted organic layer was dried over magnesium sulfate and concentrated under reduced pressure. Column The concentrated reaction mixture was purified by chromatography (silica gel, ethyl acetate / n- hexane = 1/9) to obtain the object compound (102 mg, 35%) as a white solid.

6314-28-9 Benzo[b]thiophene-2-carboxylic acid 95864, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; JUNG, YOUNG SIK; KIM, PIL HO; HAN, SOO BONG; RAGHAVENDRA, ACHARY; KIM, MEE HYEIN; LEE, CHONG KYO; SHIN, JIN SOO; (131 pag.)KR2015/25531; (2015); A;,
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Simple exploration of 22913-24-2

The synthetic route of 22913-24-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22913-24-2,Methyl benzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

Under N2 atmosphere, an oven-dried 4 mL vial was charged with methyl benzo[b]thiophene-2-carboxylate (27.7 mg, 0.300 mmol, 1.00 equiv), palladium complex 1 (11.4 mg, 15.0 mupiiotaomicron, 5.00 mol%), Ag(bipy)2C104 (16.0 mg, 30.0 mupiiotaomicron, 10.0 mol%), and NFBS (0.189 g, 0.600 mmol, 2.00 equiv). Acetonitrile (0.75 mL, c = 0.40 M) was added and the reaction mixture was stirred in a sealed vial at 4 C for 24 h. Subsequently, triethylamine (30.5 mg, 42.0 mu, 0.300 mmol, 1.00 equiv) was added and the reaction mixture was concentrated in vacuo. The residue was purified by chromatography on silica gel, eluting with hexanes/EtOAc (19: 1 to 4: 1 (v/v) with 1% triethylamine), to afford 115 mg of the title compound as a colorlesssolid (79% yield). [00237] R/= 0.38 (hexanes/EtOAc 7:3 (v/v)). NMR Spectroscopy: 1H NMR (600 MHz, CDC13, 23 C, delta): 7.98-8.00 (m, 4H), 7.83 (d, J = 8.2 Hz, 1H), 7.66-7.70 (m, 2H), 7.53 (t, J = 7.9 Hz, 4H), 7.46 (td, J = 1.6, 1.2 Hz, 1H), 7.30-7.33 (m, 1H), 7.25-7.28 (m, 1H), 3.39 (s, 3H). 13C NMR (125 MHz, CDC13, 23 C, delta): 160.9, 139.8, 138.2, 137.4, 134.6, 134.2, 129.4, 128.9, 128.8, 127.8, 125.4, 124.8, 122.8, 52.3. Mass Spectrometry: HRMS (ESI-TOF) (m/z): calcd for C22H2iN206S3 [M + NH4]+, 505.0556, found, 505.0569., 22913-24-2

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Reference£º
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; NGAI, Ming-Yu; BOURSALIAN, Gregory, Bagrad; MCNEILL, Eric, Andrew; RITTER, Tobias; WO2015/31725; (2015); A1;,
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Brief introduction of 20699-85-8

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20699-85-8, Methyl 5-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 168 (1.259 g, 5.31 mmol) and compound 61 (1.00 g, 4.83 mmol) were dissolved in DMF (6.0 mL). EDC?HC1 (1.11 g, 0.476 mmol) and DMAP (0.295 g, 2.41 mmol) were added. The reaction mixture was allowed to stir at ft under Ar overnight. After stirring overnight, DI water (25 mL) was added to the reaction mixture to precipitate the product. The slurry was stirred at ft for 5 mm and was then filtered. The resulting solids were placed on high vacuum to dryness to give crude 169, which was used directly in the next step (2.058 g, 5.31 mmol, 100% yield). UPLCMS (2.5 mm method) = 1.84 mm. Mass observed (ESI): 427.2 (M+H)., 20699-85-8

Big data shows that 20699-85-8 is playing an increasingly important role.

Reference£º
Patent; IMMUNOGEN, INC.; MILLER, Michael, Louis; SHIZUKA, Manami; CHARI, Ravi, V.J.; (312 pag.)WO2019/133652; (2019); A1;,
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Analyzing the synthesis route of 20532-33-6

20532-33-6, 20532-33-6 5-Chlorobenzothiophene 11309754, abenzothiophene compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20532-33-6,5-Chlorobenzothiophene,as a common compound, the synthetic route is as follows.

5-Chlorobenzothiophene was prepared by procedures known in the art (J. Heterocyclic Chem. 1988, 25, 1271). 1.68 g (9.96 mmol) of the compound were dissolved in 20 ml dry ether, and the solution was kept under argon at room temperature, while 6.25 ml (10 mmol) of a 1.6 M solution of butyl lithium in hexane was added dropwise. It was stirred for 30 min, cooled to -30 C. followed by slow addition of 1.60 g (10.0 mmol) bromine. After 30 min stirring at this temperature cooling was stopped, and the mixture was washed with aqueous sodium thiosulfate solution. The organic layer was dried over sodium sulfate and concentrated under reduced pressure, and the title benzothiophene was obtained after chromatography on silica gel with hexane to give 1.65 g (67%) of a colorless oil, which slowly solidified.

20532-33-6, 20532-33-6 5-Chlorobenzothiophene 11309754, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Takeuchi, Kumiko; Jirousek, Michael Robert; Paal, Michael; Ruhter, Gerd; Schotten, Theo; US2004/9976; (2004); A1;,
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New learning discoveries about 1127-35-1

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1127-35-1, Benzo[b]thiophene-3(2H)-one 1,1-Dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 1e (3.50 g, 23.46 mmol) and Compound 1f (4.28 g, 23.46 mmol) were dissolved in 1,2-dichloroethane (250 mL), and trifluoroacetic acid (70 mg, 0.62 mmol) was added. The reaction mixture was stirred for 16 hr at 50 C. The reaction mixture was washed with a saturated solution of sodium bicarbonate (250 mL), and extracted with dichloromethane (150 mL¡Á2). The organic phases were combined, dried over anhydrous sodium sulfate, filtered, concentrated under reduced pressure to dryness, and separated and purified by flash silica gel column chromatography (petroleum ether/ethyl acetate 100-60%) to give Compound 1g (4.4 g, yellow solid, yield: 36%). MS-ESI calculated value [M+ H]+ 314, measured value 314.

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Reference£º
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Medshine Discovery Inc.; YAO, Yuanshan; CHEN, Bin; CHEN, Yuan; LI, Ao; XU, Ran; HUANG, Zhensheng; TIAN, Dongdong; LI, Hongwei; YANG, Chengshuai; LI, Jian; CHEN, Shuhui; (102 pag.)EP3489233; (2019); A1;,
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