Category: benzothiophene

Amine-functional polysiloxanes (AFPs) as efficient polymeric organocatalyst for amino catalysis: efficient multicomponent Gewald reaction, α-allylic alkylation of aldehydes, and Knoevenagel condensation was written by Zheng, Zhan-Jiang;Liu, Lu-Xin;Gao, Guang;Dong, Hong;Jiang, Jian-Xiong;Lai, Guo-Qiao;Xu, Li-Wen. And the article was included in RSC Advances in 2012.Safety of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate The following contents are mentioned in the article:

In this article, for the first time, we describe that com. available and environmentally benign amine-functional polysiloxanes (AFPs) could be used as highly efficient metal-free amino catalysts in multicomponent Gewald reactions, α-allylic alkylations of aldehydes, and Knoevenagel condensations. Using catalytic amounts of AFPs, these transformations, including the Gewald reactions of ketones, sulfur, and Et 2-cyanoacetate, α-allylic alkylations of aldehydes and Knoevenagel condensations of aldehydes and the methylene-activated substrates may be carried out under mild conditions to give corresponding products in good yields. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Safety of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Safety of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Regioselective Arene and Heteroarene Functionalization: N-Alkenoxypyridinium Salts as Electrophilic Alkylating Agents for the Synthesis of α-Aryl/α-Heteroaryl Ketones was written by Zhai, Rong L.;Xue, Yun S.;Liang, Ting;Mi, Jia J.;Xu, Zhou. And the article was included in Journal of Organic Chemistry in 2018.SDS of cas: 638-02-8 The following contents are mentioned in the article:

Gold-catalyzed regioselective Friedel-Crafts reactions of terminal alkynes with arenes and heteroarenes mediated an N-hydroxypyridinium salt (generated in situ from pyridine-N-oxide and triflimide) yielded 1-(hetero)aryl-2-alkanones. The Friedel-Crafts reactions occurred via alkenyloxypyridinium salts formed in situ from an N-hydroxypyridinium salt and the terminal alkynes. The mechanism of the reaction was studied using DFT calculations, isolation and reaction of a methylenedecyloxypyridinium salt, and determination of the deuterium kinetic isotope effect in Friedel-Crafts reactions with benzene and hexadeuterobenzene. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8SDS of cas: 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.SDS of cas: 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Tris-NHC-propagated self-supported polymer-based Pd catalysts for heterogeneous C-H functionalization was written by Mandal, Tanmoy;Dutta, Tapas Kumar;Mohanty, Sunit;Choudhury, Joyanta. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.COA of Formula: C6H8S The following contents are mentioned in the article:

Three-dimensionally propagated imidazolium-containing mesoporous coordination polymer and organic polymer-based platforms were successfully exploited to develop single-site heterogenized Pd-NHC catalysts for oxidative arene/heteroarene C-H functionalization reactions. The catalysts were efficient in directed arene halogenation, and nondirected arene and heteroarene arylation reactions. High catalytic activity, excellent heterogeneity and recyclability were offered by these systems making them promising candidates in the area of heterogeneous C-H functionalization, where efficient catalysts are still scarce. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8COA of Formula: C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is also used in the manufacturing of dyes such as thioindigo.COA of Formula: C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Direct alkylation of thiophenes via bis-coupling with vinyl acetates was written by Zhang, Tong;Wang, Nai-Xing;Wu, Yue-Hua;Yan, Zhan;Xing, Yalan;Wen, Jia-Long;Gao, Xue-Wang. And the article was included in Tetrahedron Letters in 2018.Recommanded Product: 2,5-Dimethylthiophene The following contents are mentioned in the article:

A novel direct alkylation of thiophenes via bis-coupling with vinyl acetates has been developed. To the best of our knowledge, this represents the first report of the iron-catalyzed coupling of two thiophenes with vinyl groups. Utilizing earth-abundant, inexpensive, and non-toxic iron catalysts, this methodol. converts simple thiophenes to sym. dithienylethane derivatives I (R¹ = 5-Et, 5-Me, 5-Cl, etc.; R² = H, Me, (CH₂)₂COOH; R³ = H; R² = R³ = -(CH₂)₅-) under mild conditions in one step. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Recommanded Product: 2,5-Dimethylthiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Recommanded Product: 2,5-Dimethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Benzothiophene-flanked diketopyrrolopyrrole polymers: impact of isomeric frameworks on carrier mobilities was written by Huang, Jianyao;Liu, Xiaotong;Gao, Dong;Wei, Congyuan;Zhang, Weifeng;Yu, Gui. And the article was included in RSC Advances in 2016.Category: benzothiophene The following contents are mentioned in the article:

Exploring new building blocks for solution-processable polymeric semiconductors has attracted much attention. We herein develop two isomeric benzothiophene-flanked diketopyrrolopyrrole polymers with different linkage positions and further systematically study the electronic structures, optical properties, and field-effect characteristics. Both polymers exhibit typical p-type transport characteristics with the highest mobility being up to 0.80 cm² V^-1 s^-1. Our results suggest that the isomeric backbones for conjugated polymers greatly affect charge transport properties. This study involved multiple reactions and reactants, such as Ethyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 13771-68-1Category: benzothiophene).

Ethyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 13771-68-1) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and pharmacological activities of some substituted thienopyrimidine-4-ones was written by Perrissin, Monique;Favre, Marylene;Cuong Luu Duc;Huguet, Francois;Gaultier, Chantal;Narcisse, Guy. And the article was included in European Journal of Medicinal Chemistry in 1988.Recommanded Product: 95211-67-9 The following contents are mentioned in the article:

Thieno[2,3-d]pyrimidin-4-ones I [RR¹ = (CH₂)₃, (CH₂)₄, CH₂CHMeCH₂CH₂, CH₂CH₂CHMeCH₂, CHMe(CH₂)₃, (CH₂)₅; R = H, R¹ = Ph; R² = Me, CH₂Ph] were prepared by acylating the aminothiophenes II, followed by cyclization with N₂H₄. Thienopyrimidinones III were obtained from II and 3-CF₃C₆H₄CN. Analgesic and anti-inflammatory properties of these 18 compounds were investigated. Most of them showed very low toxicity. Seven compounds exhibited significant analgesic activity, six compounds displayed an anti-inflammatory activity. Some possessed both effects at levels close to those exhibited by acetylsalicylic acid. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Recommanded Product: 95211-67-9).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Recommanded Product: 95211-67-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Geographical discrimination and authentication of Chinese garlic based on multi-element, volatile and metabolomics profiling combined with chemometrics was written by Mi, Si;Zhang, Xiangnan;Wang, Yuhang;Yan, Fulong;Sang, Yaxin;Gong, Heyou;Wang, Xianghong. And the article was included in Food Control in 2021.Synthetic Route of C6H8S The following contents are mentioned in the article:

This study aims to discriminate the garlics collected from four different geog. locations of China. The multi-element (12 samples), volatile (12 samples) and metabolome (24 samples) composition of the garlics were analyzed and compared. A total of 34 chem. elements, 68 volatiles and 854 metabolites were detected in the garlic samples. Significant differences were observed in the chem. element, volatile and metabolomics profiles of the four groups of garlic. Multivariate statistics indicate that 10 chem. elements, 6 volatiles and 225 metabolites could be used as candidate markers for the separation of garlics obtained from Langfang, Jining, Kaifeng and Dali of China. The current work provides a chem. fingerprint of the selected Chinese garlics. Our results demonstrate that chem. profiling in combination with chemometrics has the potential to be used as feasible approaches for the authentication of the geog. origin of garlic. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Synthetic Route of C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is also used in the manufacturing of dyes such as thioindigo.Synthetic Route of C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors was written by Pinkerton, Anthony B.;Lee, Tom T.;Hoffman, Timothy Z.;Wang, Yan;Kahraman, Mehmet;Cook, Travis G.;Severance, Daniel;Gahman, Timothy C.;Noble, Stewart A.;Shiau, Andrew K.;Davis, Robert L.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Recommanded Product: 95211-67-9 The following contents are mentioned in the article:

A series of thiophene-containing inhibitors of kinesin spindle protein (KSP) I [R¹ = H, Me; R¹₂ = (CH₂)₄, CH₂CMe₂CH₂CH₂, CH₂OCH₂CH₂, etc.; R² = Ph, 2-thienyl, 2-furyl, 1,3-thiazol-5-yl, etc.; R³ = R⁴ = H, Me, Et; R³R⁴ = (CH₂)₃, (CH₂)₄, etc.; R³ = H, Me, R⁴ = Me₂NCH₂CH₂] was identified and synthesized. SAR studies led to the synthesis of I (R¹₂ = CH₂CH₂CHMeCH₂; R² = 2-thienyl; R³ = R⁴ = Et), which was co-crystallized with KSP and determined to bind to an allosteric pocket previously described for other known KSP inhibitors. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Recommanded Product: 95211-67-9).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Recommanded Product: 95211-67-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Identification of bioactive compounds of pyrolysis oil obtained from cotton residues (Gossypium arboreum) by flash pyrolysis was written by Madhu, P.;Periyanayagi, G.. And the article was included in International Journal of ChemTech Research in 2017.Computed Properties of C6H8S The following contents are mentioned in the article:

Pyrolysis oils have attracted a lot of interest, as they are liquid energy carriers and general sources of chems. In this work the gas chromatog.-mass spectroscopy was developed and applied for the anal. of bioactive and hydrocarbons of pyrolysis bio oil. More than 250 bioactive compounds such as normal saturated hydrocarbons, cyclopentane, cyclohexane, esters, alcs., sulfur- and bromo-containing compounds, simple pyrane, and benzene derivatives, were identified. Most of these compounds have not been reported earlier. The increase in the number of identified products is due to increased separations This increased understanding of pyrolytic product distribution can be used to enhance our understanding of the formation mechanisms of pyrolytic products. The method described in this article is a suitable research tool for the determination of various chem. compounds from pyrolysis bio oil derives from cotton shell. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Computed Properties of C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Computed Properties of C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Photochemical Intramolecular C-H Addition of Dimesityl(hetero)arylboranes by a [1,6]-Sigmatropic Rearrangement was written by Ando, Naoki;Fukazawa, Aiko;Kushida, Tomokatsu;Shiota, Yoshihito;Itoyama, Shuhei;Yoshizawa, Kazunari;Matsui, Yasunori;Kuramoto, Yutaro;Ikeda, Hiroshi;Yamaguchi, Shigehiro. And the article was included in Angewandte Chemie, International Edition in 2017.Synthetic Route of C6H8S The following contents are mentioned in the article:

A new reaction mode for triarylboranes under photochem. conditions was discovered. Photoirradiation of dimesitylboryl-substituted (hetero)arenes produced spirocyclic boraindanes, where one of the C-H bonds in the ortho-Me groups of the mesityl substituents was formally added in a syn fashion to a C-C double bond of the (hetero)aryl group. Quantum chem. calculations and laser flash photolysis measurements indicated that the reaction proceeds by a [1,6]-sigmatropic rearrangement. This behavior is reminiscent of the photochem. reaction mode of arylalkenylketones, thus demonstrating the isosteric relation between tricoordinate organoboron compounds and the corresponding pseudo-carbocationic species in terms of pericyclic reactions. Despite the disrupted π-conjugation, the resulting spirocyclic boraindanes exhibited a characteristic absorption band at relatively long wavelengths (λ=370-400 nm). This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Synthetic Route of C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is also used in the manufacturing of dyes such as thioindigo.Synthetic Route of C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem