Category: benzothiophene

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Amine (1.5 eq.) and appropriate aldehyde (1 eq.) were dissolved in MeOH/CH2Cl2 mixture(2:1 v:v), AcOH glac (1.5 eq.) was added, and the mixture was stirred under an Ar atmosphere at r.t.After 3 h, NaBH4 (6 eq.) was added, and stirring was continued for another 18 h. Solvent was removedunder reduced pressure, and the residue was dissolved in CH2Cl2. The organic layer was washed with2M NH4OH, water and then extracted with CH2Cl2. The combined organic layers were washed withbrine and dried over anhydrous Na2SO4. Finally, the solvent was evaporated under reduced pressure., 3541-37-5

The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Konstantinovi?, Jelena; Videnovi?, Milica; Srbljanovi?, Jelena; Djurkovi?-Djakovi?, Olgica; Bogojevi?, Katarina; Sciotti, Richard; ?olaja, Bogdan; Molecules; vol. 22; 3; (2017);,
Benzothiophene – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22720-75-8,2-Acetylbenzothiophene,as a common compound, the synthetic route is as follows.

To a solution of compound 1 (1.76 g, 12 mmol) and compound 2 (1.76 g, 10 mmol) dissolved in ethanol (20 ml) was added an aqueous solution of potassium hydroxide (1.12 g, 20 mmol) (1.1 ml). The mixture was stirred at room temperature overnight, and water was added to the mixture and precipitates were collected by filtration. The pre- cipitates were washed with water, dissolved in ethyl acetate-THF, and dried over anhydrous magnesium sulfate. Activated charcoal was added to the extract, and the mixture was filtered and the filtrate was concentrated. The residue was triturated from ethyl acetate-isopropyl ether to give compound 3 (2.36 g, [77 percent).] MS-APCI (m/z): 305/307 [([M+H] +)]

22720-75-8, 22720-75-8 2-Acetylbenzothiophene 89805, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Tanabe Seiyaku Co., Ltd.; WO2004/35570; (2004); A1;,
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5381-20-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

A. Preparation of nitrobenzo[b]thiophene-3-carboxaldehydes. A solution of 9 g of benzo[b]thiophene-3-carboxaldehyde in 50 ml of acetic anhydride was cooled to 0 C. by means of an external ethanol/ice bath. A solution of 40 ml of acetic acid and 20 ml of fuming nitric acid was added at such a rate to maintain the temperature of the reaction at 0-5 C. Following the addition of the reagents, the reaction mixture was stirred for 1.5 hours. The reaction mixture was poured into 500 ml of ice and extracted with ethyl acetate. The organic layer was washed with water, dried over magnesium sulfate, and evaporated in vacuo. The resulting oil was treated with ethanol. A solid formed, which was recovered by filtration providing 1.3 g of 6-nitrobenzo[b]thiophene-3-carboxaldehyde, m.p. 187-192 C. The ethanol filtrate was evaporated providing an oil which was purified by chromatography over silica gel eluding with cyclohexane.

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eli Lilly and Company; US4659717; (1987); A;,
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5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a flask containing 4.1mmol of a selected aromatic aldehyde in 10.2mL of methanol at 0C were added 0.7452g (5.4mmol) of tyramine. The solution was allowed to stir for 45min and 0.1808g (4.8mmol) of sodium borohydride was added. The solution was allowed to stir for 4.5h, at which point 0.1679g (4.4mmol) of additional sodium borohydride was added. This mixture was stirred overnight and the formed precipitate was collected via vacuum filtration. No further purification was required at this stage. The NMR spectral data for known compounds (2a [51], 2b [50], and 2e [50]) matched those in the literature. The characterization of all new compounds is given below., 5381-20-4

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

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Article; Henry, Sean; Kidner, Ria; Reisenauer, Mary R.; Magedov, Igor V.; Kiss, Robert; Mathieu, Veronique; Lefranc, Florence; Dasari, Ramesh; Evidente, Antonio; Yu, Xiaojie; Ma, Xiuye; Pertsemlidis, Alexander; Cencic, Regina; Pelletier, Jerry; Cavazos, David A.; Brenner, Andrew J.; Aksenov, Alexander V.; Rogelj, Snezna; Kornienko, Alexander; Frolova, Liliya V.; European Journal of Medicinal Chemistry; vol. 120; (2016); p. 313 – 328;,
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3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of saturated aqueous ammonium chloride (10 mL)was added dropwise with stirring to a suspension of heteroaryl-2-carbaldehyde (10 mmol), propargyl bromide (80% in toluene,2.23 g, 15 mmol) and zinc dust (3.27 g, 50 mmol) in THF(20 mL) at 0 C (ice bath) over 1 h. The mixture was allowed towarm to room temperature and was stirred at this temperaturefor 24 h, with monitoring by TLC. The mixture was filtered andthe filter cake was washed with ethyl acetate (5 100 mL). Thecombined filtrates were washed with saturated aqueousammonium chloride (50 mL), then brine (50 mL) and dried overmagnesium sulfate. The residue was purified by flash chromatographyon silica gel to afford homopropargylic alcohol as an oilyproduct. 4.2.1 rac-1-(Benzo[b]thiophen-2-yl)but-3-yn-1-ol 1a Light yellow oil (1.54 g, 76% yield); Rf: 0.3 (1:5 EtOAc/hexane); 1H NMR (CDCl3, 400 MHz): delta 7.83-7.81 (m, 1H), 7.75-7.72 (m, 1H), 7.37-7.29 (m, 2H), 7.27-7.26 (m, 1H), 5.22-5.17 (m, 1H), 2.84-2.82 (m, 2H), 2.62 (d, J = 4.7 Hz, 1H), 2.13 (t, J = 2.7 Hz, 1H); 13C NMR (CDCl3, 400 MHz): delta 146.6, 139.3, 124.4, 123.6, 122.5, 120.7, 79.7, 71.8, 69.0, 29.3.

3541-37-5, 3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Bueyuekadali, Nalan Nuriye; Seven, Semih; Aslan, Nezir; Yenidede, Duygu; Guemue, Ayeguel; Tetrahedron Asymmetry; vol. 26; 21-22; (2015); p. 1285 – 1291;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.360576-01-8,Methyl 6-bromobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

12144] A mixture of 900 mg of methyl 6-bromobenzo[b] thiophene-2-carboxylate, 2.28 ml of diisopropylamine, 116 mg of dichlorobis(triphenylphosphine)palladium (II), 32mg of copper iodide (1), 0.92 ml of trimethylsilyl acetylene, and 15 ml of toluene was stirred for 20 hours at room temperature under a nitrogen atmosphere. The reaction mixture was concentrated under reduced pressure, hexane was added to the residues, and insoluble matter was separated by filtration. The filtrate was concentrated under reduced pressure, and the residues were subjected to silica gel colunm chromatography, thereby obtaining 590mg ofmethyl 6-(trimethylsilylethynyl) benzo[b]thiophene-2-carboxylate.

360576-01-8, As the paragraph descriping shows that 360576-01-8 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.,5381-20-4

General procedure: As a typical experiment, the reaction of the aryl bromide (1 mmol), benzothiophene (1.5 mmol) and KOAc (0.196 g, 2 mmol) at 150C during 16 h in DMF or DMAc (4 mL) in the presence of Pd(OAc)2 (0.224 mg,0.001 mmol) or (1.12 mg, 0.005 mmol) prepared as a solution in DMAc (1 mg of Pd(OAc)2 in 1 mL of DMAc) under argon affords the coupling product after evaporation of the solvent and purificationon silica gel.

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Article; Zhao, Liqin; Bruneau, Christian; Doucet, Henri; Tetrahedron; vol. 69; 34; (2013); p. 7082 – 7089;,
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Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

5381-20-4, A mixture of 2-aminohistamine (0.11 mmol) and 3-benzothiophene carboxaldehyde (0.13 mmol) was stirred in ethanol at room temperature for 6 h, after which 10% PdVC (24 mg) was added and the reaction mixture refluxed for a further 24 h. The mixture was then filtered through a celite pad, washed with ethanol (3 x 25 mL) and5 toluene (2 x 20 mL). The combined filtrates were concentrated under reduced pressure and chromatographed over silica gel using a gradient of 5:95 – 20:80 giving pure 4- (benzothiophen-3-yl)-lH-imidazo[4,5-c]pyridin-2-amine (22.2 mg; 76%) as a white solid. 1H NMR (400 MHz, CD3OD) delta 8.29 (s, IH), 8.27 (d, J = 6.5 Hz, IH), 8.10-8.07 (m, IH), 7.79-7.75 (m, IH), 7.60 (d, J= 6.5 Hz, IH), 7.55-7.48 (m, 2H). 0

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MACQUARIE UNIVERSITY; WO2009/152584; (2009); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: An aldehyde (3.24 mmol) was dissolved in EtOH (12 mL), then a solution of NH2OH*HCl (360 mg, 5.18 mmol) and Na2CO3 (247 mg,2.33 mmol) in water (3 mL) was added, and the mixture was boiled at reflux temp for 20 min. Saturated aqueous NaCl solution (30 mL)was added, and the mixture was extracted by EtOAc (2 20 mL).The combined organic layers were dried (MgSO4) and evaporated to give the expected aldoxime which was used without further purification.

3541-37-5, As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Article; Goyard, David; Konya, Balint; Chajistamatiou, Aikaterini S.; Chrysina, Evangelia D.; Leroy, Jeremy; Balzarin, Sophie; Tournier, Michel; Tousch, Didier; Petit, Pierre; Duret, Cedric; Maurel, Patrick; Somsak, Laszlo; Docsa, Tibor; Gergely, Pal; Praly, Jean-Pierre; Azay-Milhau, Jacqueline; Vidal, Sebastien; European Journal of Medicinal Chemistry; vol. 108; (2016); p. 444 – 454;,
Benzothiophene – Wikipedia
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5381-20-4,5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Dehydroacetic acid (500 mg, 2.97 mmol),3-formaldehyde benzothiophene (482.34 mg, 2.97 mmol) was dissolved in CHCl3 (4 ml).Piperidine (2d) was added dropwise,Nitrogen protection, reaction at 60 C for 12 h.The post-processing operation is the same as in Embodiment 1,A yellow solid was obtained, 507 mg (yield 54.59%).

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Jiangsu Hengrui Pharmaceutical Co., Ltd.; You Qidong; Hu Wenyuan; Jiang Zhengyu; Guo Xiaoke; Xu Xiaoli; Zhang Xiaojin; (14 pag.)CN107629041; (2018); A;,
Benzothiophene – Wikipedia
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