Category: benzothiophene

20699-85-8, Methyl 5-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

] A mixture of 500 mg of methyl 5-aminobenzo[b] thiophene-2-carboxylate, 323 mg of acetic anhydride, 623 mg of diisopropylethylamine, and 10 ml of dichloromethane was stirred for 4 hours at room temperature. The reaction mixture was washed with an aqueous saturated sodium hydrogen carbonate solution and saturated saline, dried over magnesium sulfate, and concentrated under reduced pressure. The residues were subjected to silica gel colunm chromatography, thereby obtaining 449 mg of methyl 5-(acetylamino) benzo[b]thiophene-2-carboxylate (hereinafier, described as a ?compound 67 of the present invention?).12238] Compound 67 of the Present InventionHj2239] ?H-NMR (CDC13) oe: 8.22-8.21 (m, 1H), 7.99 (s, 1H), 7.78-7.76 (m, 1H), 7.44-7.40 (m, 2H), 3.94 (s, 3H), 2.22 (s, 3H).

20699-85-8, Big data shows that 20699-85-8 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

A solution of commercially available 7-bromobenzo[b]thiophene (8.0 g, 37.5 mmol) in ether (50.0 mL) was cooled to -78 C was and treated dropwise with BuLi (1.6 M solution in Hexanes, 21 mL, 37.5 mmol) and stirred at -78 C for 20 min. The reaction mixture was treated with DMF (5.4 g, 67.4 mmol) and stirred at -78 C for 1 h. The reaction mixture was diluted with water and extracted with ether. The combined organic layer were washed with water, dried (MgSO4) filtered concentrated in vacuo and purified by chromatography (SiO2, EtOAc/Hexanes) to yield 5 as a colorless oil. 1H NMR (400 MHz, CDCl3) delta 10.25 (s, 1H), 8.12 (d, 1 H, J = 7.6 Hz), 7.90 (d, 1H, J = 7.2 Hz), 7.67 (d, 1H, J = 5.6 Hz), 7.59 (t, 1H, J = 7.6 Hz), 7.45 (d, 1H, J = 5.6 Hz)., 1423-61-6

The synthetic route of 1423-61-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Venkatraman, Srikanth; Velazquez, Francisco; Gavalas, Stephen; Wu, Wanli; Chen, Kevin X.; Nair, Anilkumar G.; Bennett, Frank; Huang, Yuhua; Pinto, Patrick; Jiang, Yueheng; Selyutin, Oleg; Vibulbhan, Bancha; Zeng, Qingbei; Lesburg, Charles; Duca, Jose; Huang, Hsueh-Cheng; Agrawal, Sony; Jiang, Chuan-Kui; Ferrari, Eric; Li, Cheng; Kozlowski, Joseph; Rosenblum, Stuart; Shih, Neng-Yang; Njoroge, F. George; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 2007 – 2017;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

Under nitrogen atmosphere, 100mL round bottom flask was charged sulfone group indanone (728mg, 4.0mmol), malononitrile (1.32g, 20.0mol) and absolute ethanol (11mL).Was then added anhydrous sodium acetate (656mg, 8.0mol), stirred at rt overnight, the reaction was completed hydrochloric acid to adjust the pH 1-2, then filtered, washed with deionized water 3-5 times, and dried in vacuo to give a white solid (847mg, yield 92%)., 1127-35-1

The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Sciences Ningbo Materials Technology And Engineering Institute; Fang Junfeng; Zhang Wenjun; Song Changjian; (26 pag.)CN109232604; (2019); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

130-03-0, Benzo[b]thiophen-3(2H)-one is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under an inert atmosphere of argon, a solution of 9 mmol of Component 4 or Component 5 together with 5 mmol of thioindoxyl in 15 mL of methanol was vigorously stirred and to which small portions of Na2CO3 was added. After 1 h of stirring at 45 C, the dark red residue was filtered and successively and intensively washed with methanol and cold water. The resulting precipitate was filtered and purified by silica gel column chromatography (ethyl acetate:hexane 1:2).

130-03-0, 130-03-0 Benzo[b]thiophen-3(2H)-one 10986413, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Hosseinnezhad, Mozhgan; Moradian, Siamak; Gharanjig, Kamaladin; Dyes and Pigments; vol. 123; (2015); p. 147 – 153;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

General procedure: Benzo[b]thiophen-3(2H)-one 1,1-dioxide (BTD) (1mmol) and aldehyde2a-2d (1 mmol) were dissolved in 3 mL ethanol and refluxed for4-5 h. The progress of the reactionwas monitored by TLC. After completion,the reaction mass was cooled and filtered. The product obtainedwas crystallized from hot absolute ethanol (Scheme 1).

1127-35-1, The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bhagwat, Archana A.; Mohbiya, Dhanraj R.; Avhad, Kiran C.; Sekar, Nagaiyan; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 203; (2018); p. 244 – 257;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130-03-0,Benzo[b]thiophen-3(2H)-one,as a common compound, the synthetic route is as follows.

A representative procedure for synthesis of thioaurones is as follows. To a solution of 150 nig (1.00 mmol) of 1-thiobenzofuranone and the required aldehyde (1 mmol) in 2 mL of methanol was added 2 mL of a 50% by weight solution of potassium hydroxide in methanol. This mixture was heated to 60 C in a CEM microwave reactor for 30 minutes. After cooling, the reaction was acidified with 1-N HC1 and partitioned between ethyl acetate and water. The organic layer was directly concentrated in vacuo and then purified via column chromatography on silica using ethyl acetate/hexanes mixtures to afford the desired thioaurone product as a solid in 20-50% yield. These products displayed spectroscopic data consistent with the assigned structure., 130-03-0

The synthetic route of 130-03-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MIDDLE TENNESSEE STATE UNIVERSITY; STUBBLEFIELD, Jeannie; TAYLOR, Zachary, E.; HANDY, Scott; FARONE, Mary; MCCLELLAND, Erin; SUTTON, Caleb; FARONE, Anthony; PARK, Hyo; ARAUJO, Danielle; (247 pag.)WO2017/180644; (2017); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

4923-87-9,4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

n-Butyl lithium (0.64ml, 1.2 mmol) was added drop wise to a solution of diisopropyl amine (0.25 mL, 1.5 mmol) in dry THF at -78C under nitrogen atmosphere over a period of 5 minutes. The reaction mixture was stirred at -20C for 30 minutes. To this was added 5-bromo-benzo[b]thiophene (200mg, 0.938 mmol) in dry THF at -78C, continued stirring for a further 30 minutes at -78C, followed by the addition of N-chlorosuccinamide (225mg, 1.68mmol) in dry THF at -78C. The resulting mixture was stirred at room temperature for 2 hours. The reaction was monitored by TLC (100% hexane). The reaction mixture was partitioned between ethyl acetate and saturated ammonium chloride. The organic layer was dried over sodium sulfate and concentrated to afford the crude product. Purification by column chromatography on silica gel (100% hexane) afforded 70mg of the product (30%> yield).1H NMR (CDC13, 300 MHz): 87.815-7.811 (d, IH), 7.57-7.55 (d, IH), 7.44- 7.41 (dd, IH), 7.12 (s, IH).

The synthetic route of 4923-87-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; BOCK, Mark Gary; GAUL, Christoph; GUMMADI, Venkateshwar Rao; SENGUPTA, Saumitra; WO2012/149413; (2012); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130-03-0,Benzo[b]thiophen-3(2H)-one,as a common compound, the synthetic route is as follows.

To a 5 mL flame-dried microwave flask was added benzo[b]thiophen-3(2H)-one (0.24 mmol, 0.12 equiv) and 5-aryl-2-formylpyrrole (0.2 mmol, 0.1 equiv). The flask was capped with analuminume-PTFE crimp cap, sealed, and evacuated and backfilled with nitrogen three times. To the flask was then added anhydrous toluene (2 mL, 0.1M in aldehyde) and piperidine (10 mL, 0.1 mmol,0.5 equiv). The flask was transferred to a pre-warmed oil bath set to 111 C and stirred for 2 h. After 2 h the flask was removed from theoil bath and cooled to room temperature and then to 0 C in a water-ice bath. To the flask was added hexanes (5 mL) and the flask was allowed to sit for an addition 10-30 min. The mixture was the filtered, and the precipitate was then triturated with hexanes to until the filtrate ran clear to provide the pure product as a red, blue,or purple solid depending on the substrate.

130-03-0, 130-03-0 Benzo[b]thiophen-3(2H)-one 10986413, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Zweig, Joshua E.; Ko, Tongil A.; Huang, Junrou; Newhouse, Timothy R.; Tetrahedron; vol. 75; 34; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

346592-74-3, 7-Fluorobenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 4-1Preparation of Compound 4-7 [0507j Compound 4-6 (12 g, 79 mmol) and dichloromethyl methyl ether (13.5, 118 mmol) were dissolved in anhydrous DCM (400 mL). To the solution was added titanium tetrachloride (23 g, 122 mmol). After stirring at rt for 1 h, the mixture was poured into a mixture of saturated aqueous NaHCO3 and ice. The mixture was stirred for about 30 mins and then extracted with DCM. The organic layer was dried over sodium sulfate and concentrated. The residue was purified by column chromatograph on silica gel (PE:EA=80: 1 to 20:1) to give 4-7 (6.0 g, 40 %). ?H-NMR (400MHz, d-DMSO), &10.14 (d, J1.0 Hz, 1 H), 9.05 (s, 1 H), 8.36-8.34 (m, 1 H), 7.60-7.55 (m, 1 H), 7.4 1-7.37 (m, 1 H)., 346592-74-3

The synthetic route of 346592-74-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ALIOS BIOPHARMA, INC.; WANG, Guangyi; BEIGELMAN, Leonid; TRUONG, Anh; NAPOLITANO, Carmela; ANDREOTTI, Daniele; HE, Haiying; WO2014/31784; (2014); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17402-83-4,Benzo[b]thiophen-4-amine,as a common compound, the synthetic route is as follows.

General procedure: 2 ml of pyridine, 257 mg of N-[3-(dimethylamino)propyl]-N?-ethylcarbodiimide hydrochloride and 223 mg of benzo[B]thiophen-4-ylamine are added to a solution of 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of example 1, in 2 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature for 15 hours, and then concentrated under reduced pressure. Water and ethyl acetate are added and the resulting mixture is thus stirred for 30 minutes. The precipitate formed is filtered off, and rinsed with water, ethyl ether and petroleum ether. The solid obtained is dried under vacuum. 262 mg of N-(1-benzothiophen-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the formed of an off-white solid

17402-83-4, As the paragraph descriping shows that 17402-83-4 is playing an increasingly important role.

Reference£º
Patent; Sanofi; Cali, Jean – Christophe; Sertar, Victor; Array, Frank; Carlson, Carl Andreas; Shio, Laulan; Thompson, Fabienne; (178 pag.)JP5680638; (2015); B2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem