Category: benzothiophene

Thieno[2.3-d]-4-pyrimidones: synthesis, structure and pharmacological properties was written by Perrissin, Monique;Favre, Marylene;Luu-Duc, Cuong;Bakri-Logeais, Francoise;Huguet, Francois;Narcisse, Guy. And the article was included in European Journal of Medicinal Chemistry in 1984.Safety of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate The following contents are mentioned in the article:

The cyclization of 2-aminothiophenes I [R = CO₂Et; R¹ = Ph, R² = H; R¹R² = (CH₂)₃, (CH₂)₄, CHMe(CH₂)₃, CH₂CHMeCH₂CH₂, CH₂CH₂CHMeCH₂, (CH₂)₅] with HCONH₂ or PhCN yields 4-pyrimidones II (R³ = H, Ph). Similar reaction of I (R = CONH₂) with (MeCO)₂CH₂ gave II (R³ = Me). Their structure and their lactam-lactim tautomerism were investigated by IR spectroscopy. Ten II have analgesic activity equal or superior to that of aspirin. Only II [R¹R² = (CH₂)₃, CH₂CHMeCH₂CH₂, R³ = H] have some antiinflammatory activity. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Safety of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Safety of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Volatile composition and sensory characteristics of onion powders prepared by convective drying was written by Choi, So Mang;Lee, Dong-Jin;Kim, Jong-Yea;Lim, Seung-Taik. And the article was included in Food Chemistry in 2017.Reference of 638-02-8 The following contents are mentioned in the article:

Volatile composition and sensory characteristics of onion powders prepared by convective drying at different temperatures (50, 70, and 90 °C) were investigated. Di-Pr disulfide was the major volatile compound in fresh onion (77.70% of total volatile compounds). However it was considerably lost during drying, reaching 6.93-32.25 μg/g solids. Di-Pr disulfide showed a pos. correlation with green sensory attribute perceived by descriptive sensory anal. Thiophenes, which were responsible for caramel and sweet attributes, were produced by drying especially when the drying temperature was high. Aldehydes, another type of volatile compound found in fresh onion, showed a pos. correlation with humidity. The aldehyde content in dried onion was the highest at the lowest drying temperature, possibly because the aldehydes were produced by the residual enzymes in fresh onion. Using a low temperature for drying was ideal to retain the aroma of fresh onion. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Reference of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is also used in the manufacturing of dyes such as thioindigo.Reference of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Unlocking the Friedel-Crafts arylation of primary aliphatic alcohols and epoxides driven by hexafluoroisopropanol was written by Zhang, Shaofei;Vayer, Marie;Noel, Florent;Vukovic, Vuk D.;Golushko, Andrei;Rezajooei, Nazanin;Rowley, Christopher N.;Leboeuf, David;Moran, Joseph. And the article was included in Chem in 2021.Recommanded Product: 638-02-8 The following contents are mentioned in the article:

The limitations thar easily overcome using Bronsted acid catalysis in hexafluoroisopropanol (HFIP) as a solvent were reported. Electron-poor aromatic epoxides and aliphatic epoxides undergo stereospecific arylation to give alcs. RC(R¹)(Ar)CH₂OH/RCH(OH)CH(Ar)OH, and based on the reaction conditions, it can partake in a second nucleophilic substitution with a different arene ArH in one pot. Ph ethanols R³(CH₂)₂OH (R³ = Ph, 2,6-dichlorophenyl, 2,4,6-trimethylphenyl, etc.) react through a phenonium intermediate, whereas simple aliphatic alcs. e.g., cyclopentanol participate in a rare intermol. SN2 Friedel-Crafts process, delivering linear products e.g., 1,3,5-trimethyl-2-phenethylbenzene exclusively. In this work, an alternative to metal-catalyzed cross-couplings was provided for accessing important scaffolds, and widening the range of applications of the Friedel-Crafts reaction. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Recommanded Product: 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Recommanded Product: 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis Characterization and In Vitro Antibacterial Activity of the N-Substituted Bis-Pyrazoline Derivative as Polycyclic Aromatic Compounds was written by Aqlan, Faisal M.. And the article was included in Polycyclic Aromatic Compounds in 2022.Reference of 638-02-8 The following contents are mentioned in the article:

N-substituted bis-pyrazolines I [R = 4-MeC₆H₄NH, 2-ClC₆H₄NH, 4-O₂NC₆H₄NH, 2,4-F₂C₆H₃NH, 2,6-F₂C₆H₃NH] were synthesized by the reaction of bis-chalcone with N-substituted thiosemicarbazide derivatives under basic conditions. The bis-chalcone was synthesized by the reaction of 1-(2,5-dimethylthiophen-3-yl)ethan-1-one with terephthalaldehyde under basic condition. The in vitro antibacterial activity of I was estimated against two Gram-pos. and two Gram-neg. bacterial strains by the disk diffusion method and min. inhibitory concentration (MIC) method and the results were compared with standard drug Amoxicillin. The structure-activity relationship showed that I (R = 2-ClC₆H₄NH) was more active than standard drug Amoxicillin. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Reference of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Reference of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Highly fluorescent response of 4-(2,5-dimethylthiophen-3-yl)-2- hydroxyphenylbenzothiazole toward BF₃·Et₂O and Zn²⁺ was written by Liu, Yingfan;Li, Xiaochuan;Min, Kyeong Su;Son, Young-A.. And the article was included in Molecular Crystals and Liquid Crystals in 2018.Related Products of 638-02-8 The following contents are mentioned in the article:

In this contribution, the emission response of 4-(2,5-dimethylthiophen-3-yl)-2-(2-hydroxyphenyl)benzothiazole (THBT) was investigated in detail. The exptl. shows that Zn²⁺ could induce fluorescence increasing in THF. Especially, the quenched emission of THBT was significantly enhanced with 0.76 quantum yield. Due to the coordination of Zn²⁺, the excited state intramol. proto transfer (ESIPT) was inhibited and leads to emission quenching correspondingly. The strong emission could ascribe to the Zn-THBT complex. As well, the addition of BF₃·Et₂O also could form fluorine-boron complex and inhibit ESIPT effect. Addnl., the BF complex is also a strong blue emitter. Therefore, strong blue emission upon BF₃·Et₂O addition to THBT in dioxane was found. The possible coordinating mechanisms of THBT coordinate with Zn²⁺ and BF₃·Et₂O were given. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Related Products of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Related Products of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Prediction of flash points of pure organic compounds: Evaluation of the DIPPR database was written by Alibakhshi, A.;Mirshahvalad, H.;Alibakhshi, S.. And the article was included in Process Safety and Environmental Protection in 2017.Formula: C6H8S The following contents are mentioned in the article:

The flash point is one of the most important flammability properties of compounds for the design of inherently safe processes. Many models have been developed to predict the flash point using the DIPPR database. However, for only 740 of the 1628 organic compounds available in the DIPPR database, the data for both flash point and normal b.p. were exptl. determined For the other compounds, at least one of these properties was predicted and therefore is not appropriate for model development. The present study introduces a model to predict the flash points of pure organic compounds using their mol. structures and normal b.ps. The new model exploits the equality of the relative errors observed for the normal b.p. and flash point values predicted using the Joback method. Consequently, the relative error of the predicted normal b.ps. can be used as a scaling factor to modify the predicted flash points. The ability of the model to evaluate the accuracy of a database was investigated. The ratio of the relative error of the predicted flash point to the relative error of the predicted normal b.p. obtained using the Joback method was proposed as a measure to evaluate the accuracy of flash point data. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Formula: C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Formula: C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Microwave-Assisted Synthesis, Physicochemical, and Optical Properties of Extended Pi (π) Bond Pyrazoline Derivative was written by Zayed, Mohie E. M.;Kumar, Parveen. And the article was included in Polycyclic Aromatic Compounds in 2021.Related Products of 638-02-8 The following contents are mentioned in the article:

The title compound 2-(3-(2,5-dimethylthiophen-3-yl)-5-(2,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzo[d]thiazole (DTPH) was synthesized by the reaction of (E)-1-(2,5-dimethylthiophen-3-yl)-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-one (DTPO) with 2-hydrazinyl benzothiazole under microwave irradiation Chalcone was synthesized by the reaction of 1-(2,5-dimethylthiophen-3-yl)ethan-1-one with 2,4,5-trimethoxybenzaldehyde under same conditions. The structure of the DTPH was confirmed by the spectroscopic techniques (IR, ¹H-NMR, ¹³C-NMR, EI-MS) and elemental anal. The physicochem. behavior of newly synthesized DTPH was determined in different solvents. As a result of the measurements, a large red shift in the fluorescence of the DTPH studied was observed, when the polarity of the solvents increases (n-Hexane to DMSO). Optical properties of DTPH such as dipole moment, oscillator strength, stokes shift, and fluorescence quantum yields were determined in different polarities of the solvents. The effect of cationic and anionic surfactant such as CTAB and SDS on DTPH dye was also studied to determine the critical micelle concentration of CTAB and SDS surfactants. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Related Products of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Related Products of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Targeted analyte deconvolution and identification by four-way parallel factor analysis using three-dimensional gas chromatography with mass spectrometry data was written by Watson, Nathanial E.;Prebihalo, Sarah E.;Synovec, Robert E.. And the article was included in Analytica Chimica Acta in 2017.Related Products of 638-02-8 The following contents are mentioned in the article:

Comprehensive three-dimensional gas chromatog. with time-of-flight mass spectrometry (GC³-TOFMS) creates an opportunity to explore a new paradigm in chemometric anal. Using this newly described instrument and the well understood Parallel Factor Anal. (PARAFAC) model the authors present one option for use of the novel GC³-TOFMS data structure. The authors present a method which builds upon previous work in both GC³ and targeted anal. using PARAFAC to simplify some of the implementation challenges previously discovered. Conceptualizing the GC³-TOFMS instead as a 1-dimensional gas chromatograph with GC × GC-TOFMS detection the authors allow the instrument to create the PARAFAC target window natively. Each 1st dimension modulation thus creates a full GC × GC-TOFMS chromatogram fully amenable to PARAFAC. A simple mixture of 115 compounds and a diesel sample are interrogated through this methodol. All test analyte targets are successfully identified in both mixtures Mass spectral matching of the PARAFAC loadings to library spectra yielded results >900 in 40 of 42 test analyte cases. Twenty-nine of these cases produced match values >950. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Related Products of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Related Products of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Roles of different initial Maillard intermediates and pathways in meat flavor formation for cysteine-xylose-glycine model reaction systems was written by Hou, Li;Xie, Jianchun;Zhao, Jian;Zhao, Mengyao;Fan, Mengdie;Xiao, Qunfei;Liang, Jingjing;Chen, Feng. And the article was included in Food Chemistry in 2017.HPLC of Formula: 638-02-8 The following contents are mentioned in the article:

To explore initial Maillard reaction pathways and mechanisms for maximal formation of meaty flavors in heated cysteine-xylose-glycine systems, model reactions with synthesized initial Maillard intermediates, Gly-Amadori, TTCA (2-threityl-thiazolidine-4-carboxylic acids) and Cys-Amadori, were investigated. Relative relativities were characterized by spectrophotometrically monitoring the development of colorless degradation intermediates and browning reaction products. Aroma compounds formed were determined by solid-phase microextraction combined with GC-MS and GC-olfactometry. Gly-Amadori showed the fastest reaction followed by Cys-Amadori then TTCA. Free glycine accelerated reaction of TTCA, whereas cysteine inhibited that of Gly-Amadori due to association forming relatively stable thiazolidines. Cys-Amadori/Gly had the highest reactivity in development of both meaty flavors and brown products. TTCA/Gly favored yielding meaty flavors, whereas Gly-Amadori/Cys favored generation of brown products. Conclusively, initial formation of TTCA and pathway involving TTCA with glycine were more applicable to efficiently produce processed-meat flavorings in a cysteine-xylose-glycine system. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8HPLC of Formula: 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.HPLC of Formula: 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

S,O-Ligand-Promoted Pd-Catalyzed C-H Olefination of Thiophenes was written by Alvarez-Casao, Yolanda;Fernandez-Ibanez, M. Angeles. And the article was included in European Journal of Organic Chemistry in 2019.Category: benzothiophene The following contents are mentioned in the article:

An efficient palladium(II)-catalyzed C-H olefination of thiophenes was developed to afford thiophenyl acrylates I [R¹ = Me, CO₂Me, Cl, etc.; R² = 3-methoxy-3-oxo-prop-1-enyl, 3-butoxy-3-oxo-prop-1-enyl, 3-(dimethylamino)-3-oxo-prop-1-enyl, etc.; R³ = H, 3-methoxy-3-oxo-prop-1-enyl, 3-butoxy-3-oxo-prop-1-enyl, 3-(dimethylamino)-3-oxo-prop-1-enyl, etc.] and II [R⁴ = 3-ethoxy-3-oxo-prop-1-enyl, 3-butoxy-3-oxo-prop-1-enyl, 3-(dimethylamino)-3-oxo-prop-1-enyl, etc.; R⁵ = H, Me, OMe, etc.; R⁶ = H, 3-butoxy-3-oxo-prop-1-enyl; R⁷ = H, 3-butoxy-3-oxo-prop-1-enyl] using an easily accessible bidentate S,O-ligand. The catalytic system promoted the C-2 olefination of a wide range of thiophenes bearing both electron donating and withdrawing groups under mild conditions. This methodol. provided a direct path toward the synthesis of I and II which were difficult to obtain via other C-H functionalization routes. The S,O-ligand was responsible for the broad substrate scope and high levels of C-2 selectivity in compounds I. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Category: benzothiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is also used in the manufacturing of dyes such as thioindigo.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem