Category: benzothiophene

6314-28-9, Benzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6314-28-9

Benzo[b]thiophene-2-carboxylic acid 2-[(benzo[b]thiophene-2-carbonyl)-(R)-amino]-3-[4-(3-hydroxycarbamoyl-propyl)-piperidin-1-yl]-3-oxo-propyl ester; A mixture of HOAt (20 mg, 0.15 mmols), Fmoc-D-Ser-OH (49 mg, 0.15 mmols) and diisopropylcarbodiimide (0.024 ml, 18 mg, 0.15 mmols) in 3 ml of DMF/DCM, previously maintained at ambient temperature for an hour, is added to the resin obtained in Step C, re-swollen in 2 ml of DCM for 20 minutes. The suspension is agitated for 18 hours at ambient temperature then the resin is filtered off and washed sequentially with DMF (2¡Á2 ml) and DCM (2¡Á2 ml).The resin is filtered off and suspended in 2 ml of a solution of 20% piperidine in dichloromethane. After 30 minutes the resin is filtered off and washed sequentially with DMF (2¡Á2 ml) and DCM (2¡Á2 ml).To the resin obtained in Step E and re-swollen in 2 ml of DCM for 20 minutes are added the mixture of HOAt (68 mg, 0.5 mmols), benzo[b]thiophene-2-carboxylic acid (90 mg, 0.5 mmols) and 0.08 ml of diisopropylcarbodiimide (63 mg, 0.5 mmols) in 3 ml of DMF/DCM previously held at ambient temperature for 1 hour. The suspension is agitated for 18 hours at ambient temperature. The resin is filtered off and washed sequentially with DMF (2¡Á2 ml) and DCM (2¡Á2 ml).100 mul of trifluoroacetic acid and 100 mul of triethylsilane are added to the thus obtained resin, re-swollen in 2 ml DCM for 20 minutes. It is maintained under agitation for 15 minutes at ambient temperature. The resin is filtered off and washed twice with DCM and MeOH alternately. The filtrates are pooled and evaporated to dryness. Grinding the crude product thus obtained with ethyl ether provides the desired product (41 mg, 75% yield) with a purity of 95% (HPLC, 214 nm). MF: C30H31N3O6S2, MW: 593.73.

The synthetic route of 6314-28-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Rossi, Cristina; Porcelloni, Marina; D’Andrea, Piero; Fattori, Daniela; Marastoni, Elena; US2008/207694; (2008); A1;,
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17402-83-4, Benzo[b]thiophen-4-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Aminobenzo [b] thiophene 14. 92 g(100 mmol) was added to the reaction flask with di (2-chloroethyl) amine hydrochloride and 85 g (5 mmol) of p-toluenesulfonamide and 225 mL of xylene were added at 120 to 150 ¡ã C C under stirring for 16 hours. And then naturally dropped to room temperature, and then reduced to 0 ¡ã C for 2 hours, filtered to obtain white solid crystal 21. 66g, the yield of 85. 0percent, 98percent purity.

17402-83-4, The synthetic route of 17402-83-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shenzhen Foncoo Pharmaceutical Co., Ltd.,; Peng, Jin An; Zhou, Gewen; (6 pag.)CN105461703; (2016); A;,
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22913-24-2, Methyl benzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 60% NaH (0.12g, 5mmol) was added in anhydrous THF (10mL), followed by the addition of anhydrous CH3CN (0.21g, 5mmol) and compound 2 (0.42g, 2.5mmol) in the ice bath. Reaction was heated to reflux and stirred for 6h. Upon completion, the reaction mixture was taken up in ice water (30mL) and the pH was adjusted to 5. After filtration, the filtrate was extracted with ethyl acetate (20mL¡Á3). The combined organic phase was washed twice with saturated brine (20mL¡Á2) and dried over anhydrous MgSO4. Then, MgSO4 was filtered out, and the filtrate was concentrated in vacuo, Followed by recrystallization of the residue to afford compound 19a as a pale-yellow solid.

22913-24-2, As the paragraph descriping shows that 22913-24-2 is playing an increasingly important role.

Reference£º
Article; Heng, Hao; Wang, Zhijie; Li, Hongmei; Huang, Yatian; Lan, Qingyuan; Guo, Xiaoxing; Zhang, Liang; Zhi, Yanle; Cai, Jiongheng; Qin, Tianren; Xiang, Li; Wang, Shuxian; Chen, Yadong; Lu, Tao; Lu, Shuai; European Journal of Medicinal Chemistry; vol. 176; (2019); p. 248 – 267;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 4-aminoacetophenone (0.01 mol) with 0.01 mol of NaOH dissolved in 50 mL of water and 50 mL of ethanole was stirred for 30 min. Upon addition of 5-phenylthiophene-2-carboxy aldehyde or benzo[b]thiophene-2-carboxy aldehyde (0.01 mol), the reaction mixture was stirred at room temperature for 8-10 h. The reaction progress was monitored by TLC. Upon completion of the process, the mixture was cooled down to room temperature. The separated crystalline solid was purified by crystallization from ethanol-water (2 : 1) and dried.

3541-37-5, The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Uenver; Tuluk; Kahriman; Emirik; Bekta?; Direkel; Russian Journal of General Chemistry; vol. 89; 4; (2019); p. 794 – 799;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1034305-11-7,Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol,as a common compound, the synthetic route is as follows.

Will 35.4g (105mmol)Benzo[b]thiophene-2-methanol, alpha-(5-bromo-2-fluorophenyl) (compound of formula 3) is solubleIn 800 mL of dichloromethane,And cooled to -20 C,To this solution was added 36.5 mL (230 mmol)Triethylsilane and 15.2 mL (120 mmol) of boron trifluoride etherate,The mixture was stirred at -20 C for 30 minutes.A saturated aqueous solution of sodium hydrogencarbonate was added to the reaction mixture.The organic phase was separated and dried over magnesium sulfate.It is then filtered and dried under vacuum.The obtained crude product was purified by column chromatography (ethyl acetate-hexane).Obtaining benzo[b]thiophene,2-[(5-Bromo-2-fluorophenyl)methyl](Compound 4) 30.4g;purity99.5%; yield 90.1%;

1034305-11-7, 1034305-11-7 Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol 59281673, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Anqing Qichuang Pharmaceutical Co., Ltd.; Wu Xueping; Hai Wei; (13 pag.)CN108276396; (2018); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

(2E)-2-[(2E)-3-Methoxyprop-2-enylidene]-1-benzothiophen-3(2H)-one 1,1-Dioxide (9). A mixture of 1,3,3-trimethoxypropene (2.64 g, 20 mmol) and 1.82 g (10 mmol) of 1-benzothiophen-3(2H)-one 1,1-dioxide was heated at 90 C. for 12 h. The solid formed was recrystallized from MeOH to give 1.88 g (75% yield) of final productproduct. 1H NMR (400 MHz, CDCl3): delta 4.02 (s, 3H, OCH3), 6.51 (t, 3JH-H=12.3 Hz, 1H), 7.51-8.11 (m, 6H). GC-MS (70 eV) m/e (relative intensity): 250 (65, M+), 219 (100, (M-OCH3)+).

1127-35-1, As the paragraph descriping shows that 1127-35-1 is playing an increasingly important role.

Reference£º
Patent; The Scripps Research Institute; US7592188; (2009); B2;,
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5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5381-20-4

Benzo[b]thiophene-3-carbaldehyde (1.0 equiv.) in toluene (5 mL) was slowly added with constant stirring to a 50 mL three-necked round bottomf lask containing substituted 2-aminobenzothiazole (1.0 equiv.) and anhydrous toluene (10 mL). The reaction mixture was refluxed for 10 h and then cooled down to room temperature. The solvent was removed under reduced pressure, and the crude product was purified by recrystallization using N,N-dimethylethanamine/acetone/petroleum etherto yield pure imines 1a-1f.

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Article; Zhang, Peiwei; Tang, Chenghao; Chen, Zhiwei; Wang, Bo; Wang, Xiang; Jin, Linhong; Yang, Song; Hu, Deyu; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 189; 4; (2014); p. 530 – 540;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6314-28-9,Benzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.

6314-28-9, Benzo[b]thiophene-2-carbonyl chlorid[0104] Thianaphthene-2-carboxylic acid (356.42 mg, 2 mmol) was suspended in dry toluene (6 mL), thionyl chloride (4.4 mL, 60 mmol) and DMF (0.05 mL) were added at room temperature, and then the mixture was refluxed 8 h.4 The volatiles were removed at reduced pressure gave benzo[b]thiophene-2-carbonyl chloride as a yellow power. Purified by flash chromatography on silica gel, using ethyl acetate/hexane (1 :9) as eluent, give 3 as a white power (393.64 mg, 94.9%). Spectral data were in accordance with those published.1H-NMR (300 MHz, CDCls): delta 8.31 (s, 1H), 7.04-7.89 (m, 2H), 7.60-7.46 (m, 2H. 13C NMR (300 MHz, CDC13): delta 161.14, 144.07, 138.05, 136.59, 135.89, 128.75, 126.68, 125.66, 122.91.

As the paragraph descriping shows that 6314-28-9 is playing an increasingly important role.

Reference£º
Patent; THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE; YIN, Hang; CHENG, Kui; WO2012/99785; (2012); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24434-84-2,Benzo[b]thiophene-3-carbonitrile,as a common compound, the synthetic route is as follows.

(a) Methyl(benzo[b]thiophen-3-yl)imidate hydrochloride Benzo[b]thiophen-3-carbonitrile (700 mg) was dissolved in dry methanol (25 ml), and the resulting solution cooled to 10 C. under a dry nitrogen atmosphere. Dry hydrogen chloride gas was passed through the chilled solution for 40 minutes, and the resulting red solution allowed to stand at room temperature overnight. Removal of solvent under reduced pressure and recrystallisation from methanol/ether afforded the title compound as white needles (810 mg), m.p. 197-200 C. deltaH (360 MHz, DMSO-d6) 4.35 (3H, s, OCH3), 7.53 (2H, m, H-5,6), 8.19 (2H, m, H-4, 7) 8.41 (1H, s, H-2); m/z 191(M+, 70%) 160(100), 133(30), 89(40).

24434-84-2, The synthetic route of 24434-84-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merck Sharp & Dohme Limited; US4940703; (1990); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

Scheme I, step C: 7-bromobenzo(b)thiophene (3.01 g, 14.1 mmol, prepared above in step B) is dissolved in diethyl ether (20 mL) and the solution is added dropwise to a suspension of magnesium (0.69 g, 28.3 mmol) in diethyl ether (20 mL). Dibromoethane (1.22 mL, 14.1 mmol) in diethyl ether (10 mL) is then added dropwise to the reaction mixture, which is then heated to reflux for 3 hours. The reaction is then cooled to room temperature and 1-(t-butoxycarbonyl)-3-pyrrolidone (14.1 mmol, prepared following the procedure described in Synlett., 1, 55-57 (1995)) is added. The reaction is stirred overnight at room temperature. Water is then added to the reaction, and the mixture is extracted with diethyl ether. The organic layers are combined, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The residue is purified by flash chromatography (hexane:ethyl acetate, 7:3, silica gel) to provide 1-(t-butoxycarbonyl)-3-(7-benzo(b)thiophene)-3-hydroxy pyrrolidine.

1423-61-6, The synthetic route of 1423-61-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eli Lilly and Company; US6353008; (2002); B1;,
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