Category: benzothiophene

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of pyrrole-2-carbaldehyde 1a,b (2 mmol) in MeOH (3 mL) were added successively Na2SO4 (0.3 g), the appropriate amine 2ad (1.2 equiv), acid 3a (1.2 equiv), and isonitrile 4a,b (1.2 equiv) in a screw capped vial equipped with a magnetic stir bar. The reaction mixture was stirred at 50 C for 2448 h in a closed vial. After completion of the reaction (as indicated on TLC), the mixture was diluted with EtOAc (100 mL) and extracted with H2O (50 mL). The organic layer was washed with brine (50 mL), dried (MgSO4) and evaporated under reduced pressure to obtain a residue, which was subjected to silica gel column chromatography (50% EtOAc in heptane) to afford the desired products 5ad (Table 1)., 3541-37-5

As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Article; Kumar, Amit; Vachhani, Dipak D.; Modha, Sachin G.; Sharma, Sunil K.; Parmar, Virinder S.; Van Der Eycken, Erik V.; Synthesis; vol. 45; 18; (2013); p. 2571 – 2582;,
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6314-28-9, Benzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EDC (0.178 g, 0.928 mmol), HOBt (0.128 g, 0.947 mmol), benzo(b)thiophene-2-carboxylic acid (0.151 g, 0.847 mmol), and triethylamine (0.42 ml_, 3.01 mmol) were added to a solution of the amine-HCI salt from Example 5g (0.436 g, 0.843 mmol) in CH2CI2 (9.0 mL). The reaction mixture was stirred at room temperature for 19 h before being diluted with CH2CI2 and washed with sat. NaHCO3, 1 N HCI, sat. NaHCO3, and brine. The organic layer was dried over Na2SO4, filtered, and concentrated. Column chromatography (10-100% ethyl acetate:hexane) yielded 0.433 g (80%) of the title compound as a white solid: 1H NMR (400 MHz, CDCI3-Cy) Y ppm 7.96 – 8.03 (m, 1 H) 7.83 – 7.91 (m, 2 H) 7.76 – 7.80 (m, 1 H) 7.53 – 7.59 (m, 1 H) 7.40 – 7.48 (m, 2 H) 7.38 (dd, J=8.59, 2.02 Hz, 1 H) 6.34 (d, J=7.07 Hz, 1 H) 6.02 (d, J=8.34 Hz, 1 H) 4.27 – 4.36 (m, 2 H) 3.65 – 3.70 (m, 1 H) 3.53 – 3.62 (m, 2 H) 3.33 – 3.45 (m, 3 H) 2.65 (d, J=10.11 Hz, 1 H) 2.39 – 2.50 (m, 3 H) 2.34 (d, J=7.83 Hz, 1 H) 2.17 (s, 1 H) 1.72 – 1.78 (m, 1 H) 1.64 – 1.71 (m, 1 H) 1.53 (ddd, J=13.96, 8.65, 5.68 Hz, 1 H) 1.43 (ddd, J=13.83, 8.65, 5.05 Hz, 1 H) 0.93 – 1.01 (m, 6 H); LCMS (m/z): 641.2/643.2 (M/M + 2f., 6314-28-9

6314-28-9 Benzo[b]thiophene-2-carboxylic acid 95864, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/70865; (2007); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.360575-29-7,Methyl 4-bromobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

After dissolving methyl 4-bromobenzo [b] thiophene-2-carboxylate (1 eq) in dimethylene glycol ether (DME), tetrakis (triphenylphosphine) palladium (0) (Pd (PPh3) 4, 0.02 eq), 4-fluorophenylboronic acid (1.1 eq) and 2M sodium carbonate (2M Na2CO3, 5 eq) The mixture was stirred at 60 DEG C for 5 hours. The reaction solution was cooled to room temperature, filtered through Celite, and the reaction filtrate was washed with water and EtOAc and extracted. A small amount of water in the organic layer was removed with anhydrous MgSO 4, the solvent was removed by distillation under reduced pressure, and the product was separated into a column to obtain the target compound in 92% yield., 360575-29-7

The synthetic route of 360575-29-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chungnam National University Industry-Academic Cooperation Foundation; Kim, Uhn Hee; Yu, Sung Uhn; Kang, Nam Sook; Ku, Tae Sung; Park, Min Young; Kim, Young Hun; Bae, Hyun Ju; Kim, Jin Woo; In, Tae Gyu; Ju, Chun Gi; (44 pag.)KR101515985; (2015); B1;,
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20532-33-6, 5-Chlorobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

20532-33-6, PREPARATION IX 3-Bromo-5-chlorobenzothiophene To a solution of 0.30 gm (1.77 mMol) 5-chlorobenzothiophene 1.0 mL acetic acid was added a solution of 0.31 gm (1.95 mMol) bromine in 1.0 mL acetic acid under a nitrogen atmosphere. The reaction was heated to 50 C. for 4 hours at which time the volatiles were removed under reduced pressure. The residue was partitioned between dichloromethane and aqueous sodium bicarbonate. The phases were separated and the organics were washed with saturated aqueous sodium chloride, dried over sodium sulfate and concentrated under reduced pressure to give 0.335 gm (76%) of the title compound as a tan solid. m.p.=85-86 C. MS(FD): m/e=249 (M+2) EA: Calculated for: C8 H4 BrClS: Theory: C, 38.82; H, 1.63. Found: C, 39.12; H, 1.72.

The synthetic route of 20532-33-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eli Lilly and Company; US5874427; (1999); A;,
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360576-01-8, Methyl 6-bromobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ausgehend von 4.0 g (14.8 mmol) [6-BROM-L-BENZOTHIOPHEN-2-CARBONSaeUREMETHYL-] ester (aus Beispiel 9A) werden nach der allgemeinen Arbeitsvorschrift B 3.55 g (94 % d. Th. ) des gewuenschten Produkts erhalten. 1H-NMR (400 MHz, [DMSO-D6): No. = 13. ]48 (br. [S,] [1H),] 8. 38 (s, [1H),] 8.22 (s, [1H),] 7.96 (d, 1H), 7.63 [(M,] 1H). HPLC (Methode [1)] : Rt = 4.5 min.

360576-01-8, As the paragraph descriping shows that 360576-01-8 is playing an increasingly important role.

Reference£º
Patent; BAYER HEALTHCARE AG; WO2003/104227; (2003); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33851-23-9,Methyl 7-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: A solution of potassium tert-butoxide (1.12 g, 10 mmol) in DMSO (10 mL) was stirred at room temperature. After 10 min, the respective methyl ester (1 mmol) was added and the reaction mixture was stirred at room temperature. Upon completion (TLC analysis), ice water (40 mL) was added and the mixture was acidified with 1 N HCl until pH 1. The precipitate was collected and washed with water (5 mL), cold diethyl ether (2 mL) and hexane (5 mL) and recrystallized from an appropriate solvent., 33851-23-9

33851-23-9 Methyl 7-chloro-3-hydroxybenzo[b]thiophene-2-carboxylate 68543686, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Hansen, Finn K.; Khankischpur, Mehdi; Tolaymat, Ibrahim; Mesaros, Renata; Dannhardt, Gerd; Geffken, Detlef; Bioorganic and Medicinal Chemistry Letters; vol. 22; 15; (2012); p. 5031 – 5034;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

1423-61-6, Step a) preparation of 1-(t-butoxycarboyl)-4-(7-benzo(b)thiophene)-4-hydroxypiperidine:45 g of 7-bromobenzothiophene are dissolved in 135 ml of THF and the solution thus obtained is added dropwise to a suspension of 5.13 g of magnesium in 10 ml of THF in a round-bottomed flask under nitrogen. A catalytic amount of iodine is added and the mixture is heated at the reflux temperature for 3 hours. The resulting mixture is cooled to room temperature and a solution of 36 g of 1-(t-butoxycarbonyl)-4-piperidone in 80 ml of THF is added. This mixture is stirred for 3 hours at room temperature, and saturated ammonium chloride solution is added.The resulting mixture is extracted with ethyl acetate. The extracts are dried and evaporated under vacuum; the crude product thus obtained is purified by flash chromatography using 95/5 hexane/ethyl acetate as eluent. 47.5 g of a white solid with a melting point of 130-131 C. are isolated.

1423-61-6 7-Bromobenzo[b]thiophene 12045538, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; SANOFI; US2012/245150; (2012); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34761-09-6,Ethyl 3-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

Synthesis 1B3H-[1]benzothieno[3,2-d]pyrimid-4-oneA stirred mixture of ethyl 3-aminobenzo[b]thiophene-2-carboxylate (3.62 mmol) in formamide (5 mL) was heated to 150C. Formamidine acetate (3.62 mmol) was added and the mixture heated at 150C for 45 min. The addition of formamidine acetate (3.62 mmol) was repeated every 45 min for 6 h. Ice-water was added and the precipitate that was formed was filtered off, washed with water, and dried in a vacuum oven to obtain the pyrimidine as a tanned solid (95%).LCMS rt 5.20; M+H 203; 1H-NMR (DMSO) delta D8.33 (1H, s), 8.26-8.21 (1H, m), 8.16-8.12 (1H, m), 7.69-7.56 (1H, m).

34761-09-6, The synthetic route of 34761-09-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAELL, Jonathan Bayldon; STREET, Ian Philip; SLEEBS, Brad Edmund; WO2012/131297; (2012); A1;,
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17402-83-4, Benzo[b]thiophen-4-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 122 N-(benzo[b]thiophen-4-yl)-6-methylthiazolo[3,2-b][1,2,4]triazole-2-sulphonamide The product of Example 1 stage (c) (1.1 g) was added portionwise with stirring to 4-aminobenzo(b)thiophene (0.7 g) in dimethylaniline (4 ml.). The mixture was allowed to stand for 3 days prior to treatment with dilute hydrochloric acid and ether. The precipitated solid was isolated by filtration, washed with dilute hydrochloric acid, water and ether, and dried to give 1.4 g of crude product. This solid was treated with dilute ammonia solution, filtered, and the filtrate acidified. The precipitated product was filtered off, washed with water and ether, and dried to give 0.8 g of desired product, mp 205¡ã-209¡ã C., 17402-83-4

The synthetic route of 17402-83-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Schering Agrochemicals; US4795483; (1989); A;,
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5381-20-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Using a previously described method,23 a catalytic amount of anhydrous ZnI2 (3.2 mg, 20 mumol) and trimethylsilyl cyanide (119 mg, 1.2 mmol) was added to a stirred solution of one of the aldehydes 1a-d (1 mmol) in dry dichloromethane (10 mL) and the resulting mixture was stirred at room temperature until all of the aldehydes was transformed. The solvent was evaporated and the crude product was redissolved in 10 mL of methanol. The formed trimethylsilyl cyanohydrin decomposed when HCl (3 M, 5 mL) was added. The reaction mass was evaporated to the final volume of 5 mL, after which water (5 mL) and dichloromethane (10 mL) were added. After the separation of the two layers, the aqueous layer was extracted with dichloromethane (2 ¡Á 10 mL). The combined organic layers were dried over anhydrous Na2SO4 and the solvent was evaporated in vacuo.

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Article; Naghi, Mara Ana; Bencze, Laszlo Csaba; Brem, Juergen; Paizs, Csaba; Irimie, Florin Dan; Toa, Monica Ioana; Tetrahedron Asymmetry; vol. 23; 2; (2012); p. 181 – 187;,
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