Category: benzothiophene

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of benzo [b] thiophene-2-carbaldehyde (1.0 g, 6.17 mmol) and carbon tetrabromide (3.1 g, 9.25 mmol) in methylene chloride (50 mL) was cooled to 0C. A solution of triphenylphosphine (4.86 g, 18.3 mmol) in methylene chloride (20 mL) was added dropwise. After 1/2 hour the solution was placed on a plug of silica gel and eluted with 20% ethyl acetate: hexane. Concentration of the eluent resulted in the isolation of 1.3 g (67%) of 2-(2, 2-Dibromo-vinvl)-benzorb1thiophene as a yellow oil, which was used as such in the next step

3541-37-5, 3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; WYETH; WO2005/37207; (2005); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4923-87-9,5-Bromobenzothiophene,as a common compound, the synthetic route is as follows.

5-bromobenzo[b]thiophene (3.0 g, 14.08 mmol) and 4-hydroxyphenylboronic acid (2.91 g, 21.11 mmol) were dissolved in DME 40 mL. Water 10 mL was added thereto. Pd(dbpf)Cl2 (459 mg, 0.70 mmol) and Cs2CO3 (13.68 g, 42.24 mmol) were added thereto, and refluxed with heating at 90 C for a day. The reaction mixture was filtered through Celite. The obtained filtrate was extracted with EtOAc three times, dried over MgSO4, and then concentrated under reduced pressure. The obtained concentrate was purified by silica gel column chromatography (15-20 % EtOAc/hexane) to yield the title compound as white solid (2.30 g, 72%).

4923-87-9, The synthetic route of 4923-87-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, ChangSik; JANG, TaegSu; CHOI, DaeKyu; KO, MoonSung; KIM, DoHoon; KIM, SoYoung; MIN, JaeKi; KIM, WooSik; LIM, YoungTae; WO2013/187646; (2013); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of Mg turnings (15mmol) and iodine (two pieces) in dry diethyl ether (10mL) at room temperature equipped with a reflux condenser was added dropwise a mixture of allylbromide (11mmol) in anhydrous diethyl ether (5mL). The mixture was allowed to reflux for 30min. Then, the mixture was cooled down to 0C followed by dropwise addition of the corresponding aldehyde (benzofuran or benzothiophene) (10mmol) in dry diethylether (3mL). The resultant mixture was then stirred for 3h. The reaction mixture was hydrolyzed with saturated ammonium chloride solution (10mL) and then with 1M HCl (2mL). The resultant mixture was then extracted with diethyl ether (3¡Á30mL). The combined organic phase was washed with brine (20mL) and dried over MgSO4 and evaporated in vacuo. The crude products were purified by flash column chromatography with ethyl acetate/hexane mixture (1:5)., 3541-37-5

The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bueyuekadal?, Nalan Nuriye; Aslan, Nezir; Guemue?, Selcuk; Guemue?, Ay?eguel; Tetrahedron Asymmetry; vol. 27; 19; (2016); p. 954 – 959;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20699-85-8,Methyl 5-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of above Benzothiophene amine (104 mg, 0.5 mmol) in 5 mL of anhydrous DCM was added phenylacetic acid chloride (0.13 mL, 1.0 mmol) and DIEA (di-isopropyl ethylamine, 0.18 mL, 2.0 mmol) at room temperature under N2. The resulting mixture was stirred overnight. After work-up, the residue was purified on column (Hexanes:DCM : EtOAc = 3:1 :1 ) to afford compound 5-Phenylacetylamino- benzo[b]thiophene-2-carboxylic acid methyl ester. Yield: 71 %. LCMS m/z: 326 ([M+H]+)., 20699-85-8

The synthetic route of 20699-85-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; S*BIO PTE LTD; WO2006/101454; (2006); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6314-28-9,Benzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of phenylmethyl 4-L-leucyl-1-piperazinecarboxylate (1.0 g, 3.34 mmol) in CH2CI2 (13.5 ml_) was added EDC (571 mg, 2.98 mmol), HOOBt (8.8 mg, 0.054 mmol), i -benzothiophene-2-carboxylic acid (530mg, 2.98 mmol), and 4-methylmorpholine (1.5ml_, 13.5mmol). The reaction mixture was stirred at room temperature for 20 h whereupon the reaction was diluted with CH2CI2 and washed with 10% citric acid and brine. The organic layer was dried over Na2SO4, filtered, and concentrated. Column chromatography (10-80% ethyl acetate:hexane) afforded 1.3 g (88% yield) of the title compound as a white solid: LCMS (m/z): 494.2 (M+H)., 6314-28-9

As the paragraph descriping shows that 6314-28-9 is playing an increasingly important role.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/70865; (2007); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

16587-47-6, 6-Methylbenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 23 [0189] Preparation of (2S)-3-[4-(6-Methylbenzo[b]thiophen-2-yl)piperidinyl]-1-(1H-2-methylindol-4-yl)oxy-2-propanol oxalate. [CHEMMOL-00057] [0190] Preparation of N-t-Butoxycarbonyl-4-hydroxy-4-(6-methylbenzo[b]thiophen-2-yl)piperidine. [CHEMMOL-00058] [0191] Scheme IA, Step A: To a solution of 6-methylbenzo[b]thiophene (1.25 g, 8.43 mmol) in dry THF (20 mL) at -78 C. was added 1.6 M n-BuLi in hexanes (6.32 mL, 10.1 mmol). The solution was stirred at -78 C. for 40 min. 1-t-Butoxycarbonyl-4-piperidone (1.84 g, 9.27 mmol) dissolved in THF (10 mL) was added via a cannula at -78 C. The reaction mixture was stirred at -78 C. for 3 h. The reaction was then quenched with 50 mL of water. The mixture was extracted (3¡Á75 mL) with EtOAc. The combined organic layers were dried over MgSO4 and filtered. The filtrate was concentrated to an oil and allowed to stand 3 days in which time the material crystallized. The crystals were rinsed with a mixture of EtOAc/hexanes to give the intermediate title compound as yellow crystals (2.13 g, 72.6%). IR (KBr) 1681, 1429, 1246 cm-1. FD+MS 347.0 (M).

16587-47-6, 16587-47-6 6-Methylbenzo[b]thiophene 35790, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Hansen, Marvin Martin; He, John Xiaoqiang; Honigschmidt, Nicholas Allan; Koch, Daniel James; Kohn, Todd Jonathan; Rocco, Vincent Patrick; Spinazze, Patrick Gianpietro; Takeuchi, Kumiko; US2004/6229; (2004); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

154650-81-4, Benzo[b]thiophene-6-carbonitrile is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

K2C03 (40 mg, 0.292 mmol), Pd(OAc)2 (2.2 mg, 0.010 mmol), tricyclohexylphosphine (5.5 mg, 0.019 mmol), and pivalic acid (6 mg, 0.058 mmol) were placed in a microwave vial equipped with a magnetic stir bar. 6-Cyanobenzothiophene, INTERMEDIATE 13 (31 mg, 0.195 mmol) and l-bromo-4-(l-methylethyl)benzene (47 mg, 0.234 mmol) were added as well as DMF (0.6 ml). The sealed reaction vial was heated in a microwave reactor at 180 C for 30 min. Water and DCM were added and the organic layer evaporated. The crude product was purified by flash column chromatography using 5% EtOAc in n-heptane as eluent. Yield: 18 mg (33%); white solid. MS (ESI+) m z 278 [M+H]+. HPLC purity: 97%., 154650-81-4

As the paragraph descriping shows that 154650-81-4 is playing an increasingly important role.

Reference£º
Patent; KANCERA AB; HAMMER, Kristin; JOeNSSON, Mattias; KRUeGER, Lars; (230 pag.)WO2017/108282; (2017); A1;,
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Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

Preparation 16; 4-Benzo[]thiophen-7-yl-2-chloro-pyridine; In a flask, combine 7-bromo-benzo[?]thiophene (1.7 g, 12 mmol), 2-chloro-4- (4,4,5, 5-tetramethyl-[l,3,2]dioxaborolan-2-yl)-pyridine (1.6 g, 7 mmol), [1,1 ‘- bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane (1 : 1) (285 mg, 0.3 mmol), 2-(di-tert-butylphosphino)biphenyl (63 mg, 0.2 mmol), sodium carbonate (2 M, 8 mL, 16 mmol) and THF (20 mL). Heat the mixture at 100 0C for 3 hours. Dilute the mixture with chloroform/isopropanol (3/1). Wash the solution with saturated aqueous sodium chloride. Dry over sodium sulfate. Concentrate the solution in vacuo to a dark residue. Purify by column chromatography (dichloromethane to 20 % THF in dichloromethane) to afford the title compound (1.14 g, 66 %) as a yellow solid. MS (ES) m/z 246 [M+ 1]+., 1423-61-6

As the paragraph descriping shows that 1423-61-6 is playing an increasingly important role.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2008/76704; (2008); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

the 0.162g (1 mmol) of benzothiophene-2-carbaldehyde and 0.119g (1mmol) of ethyl thiosemicarbazide placed in a 20ml of round bottom flask, then added 2-3ml of Absolute ethanol as a solvent, followed by the dropwise addition of 2-4 drops of glacial acetic acid, stirred at reflux for 10 mins at 80 C under shade. The reaction was Cool at room temperature, a white solid precipitated, suction filtered, recrystallized from ethanol to give a white product 1- (Benzothiophen-2- methylene) -4-ethyl- thiosemicarbazide, yield 84%, Melting point: 200.3-201.2 C. The white powder turned bright yellow after being irradiated with UV light at 365 nm. The bright yellow solid turned pale yellowish after visible light irradiation., 3541-37-5

As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Patent; Xinjiang University; Liu Lang; Qiao Yuqian; Jia Dianzeng; (8 pag.)CN107298674; (2017); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20699-85-8,Methyl 5-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

A solution of 4- (4-(((6aS)-5- ((allyloxy)carbonyl)-2-methoxy-12-oxo-6-((tetrahydro-2H- pyran-2-yl)oxy)-5,6,6a,7,8,9,10,12-octahydrobenzo[e]pyriclo[1,2-a] [1,4]diazepin-3-yl)oxy)butanamido)benzoic acid (26) (40 mg, 0.061 mmol) in anhydrous dichloromethane (i mL) was charged with N- [(dimethylamino)- 1H-1,2,3-triazolo- [4,5-b]- pyridin-i-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide (25 mg, 0.064 mmol) and anhydrous triethylamine (36 pL, 0.26 mmol). The reaction mixture was stirred at room temperature for 30 mm. Methyl 5-aminobenzo[b]-thiophene-2-carboxylate (13 mg, 0.063 mmol) was then added and the resulting mixture was stirred at room temperature for 16 h. The reaction mixture was quenched with a saturated aqueous solution of sodium hydrogen carbonate (20 mL) and extracted with dichloromethane (2 x 50 mL). The combined organic extracts were washed with water containing a few drops of acetic acid (30 mL). The organic layer wasthen dried over sodium sulfate, filtered and concentrated in vacuo. The resulting residue was then purified by column chromatography (silica), eluting with methanol dichloromethane (from 0% to 10%), to give the title compound mg, 45%) as a brown oil.MS (ES+): m/z = 841 (M+H) LCMS (Method A): tR = 8.i mm., 20699-85-8

The synthetic route of 20699-85-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FEMTOGENIX LIMITED; JACKSON, Paul Joseph Mark; THURSTON, David Edwin; RAHMAN, Khondaker Mirazur; (121 pag.)WO2017/32983; (2017); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem