Category: benzothiophene

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95-15-8,Thianaphthene,as a common compound, the synthetic route is as follows.

95-15-8, EXAMPLE 11 Preparation of Benzo[b]Thiophene-2-Carboxaldehyde STR100 Butyllithium (54 mL, 134 mmol) is added dropwise to a solution of N,N,N’,N’-tetramethylethylenediamine (15.57 g, 134 mmol) in tetrahydrofuran under nitrogen at 0 C. The reaction mixture is treated dropwise with a solution of benzothiophene (15.00 g, 112 mmol) in tetrahydrofuran, warmed to room temperature, treated with additional N,N,N’,N’-tetramethylethylenediamine (15.57 g, 134 mmol) and butyllithium (54 mL, 134 mmol), stirred at room temperature for 13 hours, cooled to 0 C. treated with N,N-dimethylformamide (24.40 g, 336 mmol), warmed to room temperature, stirred for five hours, poured into one molar hydrochloric acid and extracted with ether. The combined organic extracts are washed sequentially with water and brine, dried over Na2 SO4 and concentrated in vacuo to obtain an orange oil. Flash chromatography of the oil using silica gel and a 15% ethyl acetate in hexane solution gives the title product as an orange oil (12.51 g, 69%).

As the paragraph descriping shows that 95-15-8 is playing an increasingly important role.

Reference£º
Patent; American Cyanamid Company; US5480902; (1996); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

Preparation 64; Benzo [b] thiophene-7-carboxaldehyde; Dissolve 7-bromothiophene (5.0 g, 23.5 mmol) in anhydrous tetrahydrofuran (15 mL) under nitrogen and add magnesium metal turnings (712 mg, 29.3 mmol). Stir and warm the reaction to 50C to initiate the Grignard reagent formation. After the exothermic reaction subsides, reflux for 30 minutes. Dilute the solution with tetrahydrofuran (15 ml) and cool to 25C. Add the Grignard reagent dropwise via cannula to a stirred solution of N, N-dimethylformamide (10.2g, 139 mmol) in tetrahydrofuran (25 mL) at-78C under nitrogen. Stir the reaction at 0C for 1 hour and quench with aqueous saturated ammonium chloride. Dilute with diethyl ether, wash with distilled water, and aqueous saturated sodium chloride. Dry the organic phase over anhydrous magnesium sulfate, filter, and concentrate under reduced pressure. Chromatograph on flash silica using a gradient from neat hexane to 50% ethyl acetate in hexane to obtain the title compound as an off-white solid. HRMS : 162. 0138, 1423-61-6

As the paragraph descriping shows that 1423-61-6 is playing an increasingly important role.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2003/76442; (2003); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, General procedure: To a resealable Schlenk tube was added MCM-41-PPh3-AuNTf2 (192mg, 0.05mmol). The reaction tube was evacuated and back-filled with argon and this evacuation/back-fill procedure was repeated one additional time. Aldehyde (1.0mmol), propargylamine (4.0mmol), water (5.0mmol), and DCE (4mL) were then added under a stream of argon. The reaction tube was quickly sealed and the mixture was stirred at 40C until disappearance of the starting material (TLC, typically 48h). After being cooled to room temperature, the reaction mixture was diluted with ethyl acetate (20mL) and filtered. The catalyst was washed with ethyl acetate (2¡Á5mL) and diethyl ether (2¡Á5mL), and reused in the next run. The filtrate was concentrated under reduced pressure and the residue was purified by flash chromatography (petroleum ether/ethyl acetate mixtures) to afford the corresponding product.

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Short Survey; Nie, Quan; Yao, Fang; Yi, Feiyan; Cai, Mingzhong; Journal of Organometallic Chemistry; vol. 846; (2017); p. 343 – 350;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

6314-28-9,6314-28-9, Benzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 57.5 g (0.324 mol) of benzothiophene-2-carboxylic acid in 600 ml of chlorobenzeno there are added dropwise with stirring at reflux temperature 57.8 g (0.468 mol) of thionyl chloride and, when the addition is complete, the mixture is stirred at reflux temperature until the evolution of gas has ceased. For working up, the reaction mixture is allowed to cool to room temperature and then concentrated in vacuo, the residue is stirred with n-hexane, and precipitate which has settled out is filtered off with suction and dried. 57.4 g (90% of theory) of benzothiophene-2-carboxylic acid chloride, which can be reacted further without additional purification, are obtained. STR11

As the paragraph descriping shows that 6314-28-9 is playing an increasingly important role.

Reference£º
Patent; Bayer Aktiengesellschaft; US5244893; (1993); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Into the mixture of difluoromethyltriphenylphosphoniumbromide (236 mg, 0.6 mmol), aldehyde (0.2 mmol) and DBU(90 mL, 0.6 mmol) was added DMF (2 mL) under N2. The resulting mixture was stirred at 50 C for 4 h. After being cooled to room temperature, the solution was diluted with CH2Cl2 (10 mL) andwashed with water (5 mL x 2). The organic phase was dried over sodium sulfate. The solvent was removed by concentration and the residue was subjected to column chromatography to give the pure product., 5381-20-4

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Qiang; Lin, Jin-Hong; Deng, Zu-Yong; Zheng, Jian; Cai, Ji; Xiao, Ji-Chang; Journal of Fluorine Chemistry; vol. 163; (2014); p. 38 – 41;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem