Category: benzothiophene

Zhang, Shaoqing published the artcileOver 14% Efficiency in Polymer Solar Cells Enabled by a Chlorinated Polymer Donor, SDS of cas: 1514905-24-8, the publication is Advanced Materials (Weinheim, Germany) (2018), 30(20), n/a, database is CAplus and MEDLINE.

Fluorine-contained polymers, which were widely used in highly efficient polymer solar cells (PSCs), are rather costly due to their complicated synthesis and low yields in the preparation of components. Here, the feasibility of replacing the critical fluorine substituents in high-performance photovoltaic polymer donors with chlorine is demonstrated, and two polymeric donors, PBDB-T-2F and PBDB-T-2Cl, are synthesized and compared in parallel. The synthesis of PBDB-T-2Cl is much simpler than that of PBDB-T-2F. The two polymers have similar optoelectronic and morphol. properties, except the chlorinated polymer possess lower mol. energy levels than the fluorinated one. As a result, the PBDB-T-2Cl-based PSCs exhibit higher open circuit voltage (V_oc) than the PBDB-T-2F-based devices, leading to an outstanding power conversion efficiency of over 14%. This work establishes a more economical design paradigm of replacing fluorine with chlorine for preparing highly efficient polymer donors.

Advanced Materials (Weinheim, Germany) published new progress about 1514905-24-8. 1514905-24-8 belongs to benzothiophene, auxiliary class Organic Photo-Voltaic Materials, OPV,BDT Donors, name is 4,8-Bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene, and the molecular formula is C10H14N2O, SDS of cas: 1514905-24-8.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Li, Zhao published the artcileCombined Dynamic Kinetic Resolution and C-H Functionalization for Facile Synthesis of Non-Biaryl-Atropisomer-Type Axially Chiral Organosilanes, Application of (1-Benzothiophen-4-yl)boronic acid, the publication is Chemistry – A European Journal (2021), 27(13), 4336-4340, database is CAplus and MEDLINE.

Although asym. C-H functionalization was available for the synthesis of structurally diverse mols., catalytic dynamic kinetic resolution (DKR) approaches to change racemic stereogenic axes remain synthetic challenges in this field. Here, a concise Pd-catalyzed DKR was combined with C-H functionalization involving olefination and alkynylation for the highly efficient synthesis of nonbiaryl-atropisomer-type (NBA) axially chiral organosilanes. The chem. proceeded through two different and distinct DKR: 1st, an atroposelective C-H olefination or alkynylation produced axially chiral vinylsilanes or alkynylsilanes as a new family of nonbiaryl atropisomers (NBA), and 2nd, the extension of this DKR strategy to 2-fold o,o’-C-H functionalization led to the multifunctional axially chiral organosilicon compounds with up to >99% ee.

Chemistry – A European Journal published new progress about 177735-30-7. 177735-30-7 belongs to benzothiophene, auxiliary class Boronic acid and ester,Benzothiophene,Boronic Acids,Boronic acid and ester, name is (1-Benzothiophen-4-yl)boronic acid, and the molecular formula is C8H7BO2S, Application of (1-Benzothiophen-4-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Pang, Shuting published the artcileA Facile Synthesized Polymer Featuring B-N Covalent Bond and Small Singlet-Triplet Gap for High-Performance Organic Solar Cells, COA of Formula: C34H40F2S4, the publication is Angewandte Chemie, International Edition (2021), 60(16), 8813-8817, database is CAplus and MEDLINE.

High-efficiency organic solar cells (OSCs) largely rely on polymer donors. Herein, we report a new building block BNT and a relevant polymer PBNT-BDD featuring B-N covalent bond for application in OSCs. The BNT unit was synthesized in only 3 steps, leading to the facile synthesis of PBNT-BDD. When blended with a nonfullerene acceptor Y6-BO, PBNT-BDD afforded a power conversion efficiency (PCE) of 16.1% in an OSC, comparable to the benzo[1,2-b:4,5-b’]dithiophene (BDT)-based counterpart. The nonradiative recombination energy loss of 0.19 eV was afforded by PBNT-BDD. PBNT-BDD also exhibited weak crystallinity and appropriate miscibility with Y6-BO, benefitting of morphol. stability. The singlet-triplet gap (ΔE_ST) of PBNT-BDD is as low as 0.15 eV, which is much lower than those of common organic semiconductors (≥0.6 eV). As a result, the triplet state of PBNT-BDD is higher than the charge transfer (CT) state, which would suppress the recombination via triplet state effectively.

Angewandte Chemie, International Edition published new progress about 1514905-24-8. 1514905-24-8 belongs to benzothiophene, auxiliary class Organic Photo-Voltaic Materials, OPV,BDT Donors, name is 4,8-Bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene, and the molecular formula is C34H40F2S4, COA of Formula: C34H40F2S4.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Cui, Dong published the artcileNear-infrared absorbing amphiphilic semiconducting polymers for photoacoustic imaging, Product Details of C21H26Br4S2, the publication is Journal of Materials Chemistry B: Materials for Biology and Medicine (2017), 5(23), 4406-4409, database is CAplus and MEDLINE.

Development of photoacoustic (PA) imaging agents is crucial to advancing PA imaging in biol. and medicine. In this study, we report the design and synthesis of near-IR (NIR) absorbing amphiphilic semiconducting polymers that can spontaneously self-assemble into homogeneous water-soluble nanoparticles for PA imaging of tumor in living mice.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, Product Details of C21H26Br4S2.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Li, Jingchao published the artcileSemiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy, Product Details of C21H26Br4S2, the publication is Angewandte Chemie, International Edition (2018), 57(15), 3995-3998, database is CAplus and MEDLINE.

Regulation of enzyme activity is fundamentally challenging but practically meaningful for biol. and medicine. However, noninvasive remote control of enzyme activity in living systems has been rarely demonstrated and exploited for therapy. Herein, we synthesize a semiconducting polymer nanoenzyme with photothermic activity for enhanced cancer therapy. Upon near-IR (NIR) light irradiation, the activity of the nanoenzyme can be enhanced by 3.5-fold to efficiently digest collagen in the tumor extracellular matrix (ECM), leading to enhanced nanoparticle accumulation in tumors and consequently improved photothermal therapy (PTT). This study thus provides a promising strategy to remotely regulate enzyme activity for cancer therapy.

Angewandte Chemie, International Edition published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, Product Details of C21H26Br4S2.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Akay, Senol published the artcileSynthesis and evaluation of dual wavelength fluorescent benzo[b]thiophene boronic acid derivatives for sugar sensing, Recommanded Product: (1-Benzothiophen-4-yl)boronic acid, the publication is Chemical Biology & Drug Design (2007), 70(4), 279-289, database is CAplus and MEDLINE.

Cell surface glycoproteins have been known to play very important roles in various physiol. and pathol. processes. Small mol. compounds capable of carbohydrate recognition can be very useful for the development of sensing, diagnostic, and therapeutic agents. Along this line, the authors are interested in developing water-soluble fluorescent boronic acid compounds for carbohydrate recognition. As such, a series of benzo[b]thiophene boronic acid derivatives have been synthesized and their fluorescent properties analyzed at physiol. pH. Benzo[b]thiophene derivatives were a new type of fluorescent reporter compounds capable of dual fluorescent emission under physiol. pH conditions. Many of the synthesized Compounds showed unusual emission wavelength shifts upon binding of sugars. These boronic acids will be useful tools for building glycoprotein biosensors for biol. applications.

Chemical Biology & Drug Design published new progress about 177735-30-7. 177735-30-7 belongs to benzothiophene, auxiliary class Boronic acid and ester,Benzothiophene,Boronic Acids,Boronic acid and ester, name is (1-Benzothiophen-4-yl)boronic acid, and the molecular formula is C8H7BO2S, Recommanded Product: (1-Benzothiophen-4-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Akay, Senol published the artcileSynthesis and evaluation of dual wavelength fluorescent benzo[b]thiophene boronic acid derivatives for sugar sensing, Recommanded Product: Benzo[b]thiophen-7-ylboronic acid, the publication is Chemical Biology & Drug Design (2007), 70(4), 279-289, database is CAplus and MEDLINE.

Cell surface glycoproteins have been known to play very important roles in various physiol. and pathol. processes. Small mol. compounds capable of carbohydrate recognition can be very useful for the development of sensing, diagnostic, and therapeutic agents. Along this line, the authors are interested in developing water-soluble fluorescent boronic acid compounds for carbohydrate recognition. As such, a series of benzo[b]thiophene boronic acid derivatives have been synthesized and their fluorescent properties analyzed at physiol. pH. Benzo[b]thiophene derivatives were a new type of fluorescent reporter compounds capable of dual fluorescent emission under physiol. pH conditions. Many of the synthesized Compounds showed unusual emission wavelength shifts upon binding of sugars. These boronic acids will be useful tools for building glycoprotein biosensors for biol. applications.

Chemical Biology & Drug Design published new progress about 628692-17-1. 628692-17-1 belongs to benzothiophene, auxiliary class Boronic acid and ester,Benzothiophene,Benzothiophene,Boronic Acids,Boronic Acids,Boronic acid and ester, name is Benzo[b]thiophen-7-ylboronic acid, and the molecular formula is C8H7BO2S, Recommanded Product: Benzo[b]thiophen-7-ylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Cherney, Emily C. published the artcileDiscovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization, Category: benzothiophene, the publication is Journal of Medicinal Chemistry (2022), 65(4), 3518-3538, database is CAplus and MEDLINE.

The identification of agonists of the stimulator of interferon genes (STING) pathway has been an area of intense research due to their potential to enhance innate immune response and tumor immunogenicity in the context of immuno-oncol. therapy. Initial efforts to identify STING agonists focused on the modification of 2′,3′-cGAMP (1) (an endogenous STING activator ligand) and other closely related cyclic dinucleotides (CDNs). While these efforts have successfully identified novel CDNs that have progressed into the clinic, their utility is currently limited to patients with solid tumors that STING agonists can be delivered to intratumorally. Herein, we report the discovery of a unique class of non-nucleotide small-mol. STING agonists that demonstrate antitumor activity when dosed intratumorally in a syngeneic mouse model.

Journal of Medicinal Chemistry published new progress about 129425-81-6. 129425-81-6 belongs to benzothiophene, auxiliary class Inhibitor, name is 4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid, and the molecular formula is C14H14O5S, Category: benzothiophene.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Henson, Zachary B. published the artcileSynthesis and Properties of Two Cationic Narrow Band Gap Conjugated Polyelectrolytes, COA of Formula: C21H26Br4S2, the publication is Journal of the American Chemical Society (2013), 135(11), 4163-4166, database is CAplus and MEDLINE.

We report the design, synthesis, and optical and electronic properties of two novel narrow band gap conjugated polyelectrolytes (NBGCPEs) based on a poly[2,6-(4,4-bis-alkyl-4H-cyclopenta[2,1-b;3,4-b’]dithiophene)-alt-4,7-(2,1,3-benzothiadiazole)] donor/acceptor backbone. Comparison with the properties of the neutral precursor material shows that the ionic component in these cationic NBGCPEs leads to a red-shift in the absorption spectra and to a modification of the polymer electronic energy levels. Both the HOMO and the LUMO are lowered in energy, with the net effect being dependent on the choice of counterion, i.e. bromide vs. tetrakis(1-imidazolyl)borate. Moreover, we unexpectedly find n-type transport in thin-film transistors, as opposed to the widely studied p-type transport in neutral systems with isoelectronic backbones. From these observations we conclude that introduction of ionic functionalities adjacent to semiconducting polymers that exhibit charge-transfer excitations offers unique opportunities for materials design.

Journal of the American Chemical Society published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, COA of Formula: C21H26Br4S2.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Yu, Ningyue published the artcileRadioactive organic semiconducting polymer nanoparticles for multimodal cancer theranostics, Synthetic Route of 1426829-76-6, the publication is Journal of Colloid and Interface Science (2022), 219-228, database is CAplus and MEDLINE.

Theranostics with integrations of both imaging and therapeutic elements can enable early diagnosis and effective treatment of cancer. Herein, we report the development of radioactive semiconducting polymer nanoparticles (rSPNs) for multimodal cancer theranostics. Such rSPNs constructed through labeling poly(ethylene glycol) (PEG) grafted SPNs with iodine-131 (¹³¹I) exhibit ideal photothermal property, excellent singlet oxygen (¹O₂) generating ability and good radiolabeling stability. Owing to their small particle dimension and PEG surface corona, rSPNs show an effective accumulation into s.c. tumors of living mice after systemic administration. The good fluorescence property and stable radiolabeling of rSPNs enable contrast signals for near-IR (NIR) fluorescence and single photon emission computed tomog. (SPECT) dual-model imaging of tumors. Moreover, rSPNs provide combinational action of photothermal therapy (PTT), photodynamic therapy (PDT) and radiotherapy under NIR laser irradiation, resulting in much higher therapeutic efficacy in inhibiting tumor growth and metastasis relative to SPNs-mediated treatment. This study thus offers a multifunctional organic nanosystem for multimodal cancer theranostics.

Journal of Colloid and Interface Science published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C18H10, Synthetic Route of 1426829-76-6.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem