benzothiophene | Page 74 of 647 | Heterocyclic Building Blocks-Benzothiophene

Huber, Johannes’s team published research in Macromolecules (Washington, DC, United States) in 45 | CAS: 1401018-41-4

Macromolecules (Washington, DC, United States) published new progress about 1401018-41-4. 1401018-41-4 belongs to benzothiophene, auxiliary class Organic Photo-Voltaic Materials, OPV,BT Acceptors, name is 4,8-Bis(5-bromo-4-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-c:4,5-c’]bis[1,2,5]thiadiazole, and the molecular formula is C30H36Br2N4S4, Computed Properties of 1401018-41-4.

Huber, Johannes published the artcileNanoparticles of Low Optical Band Gap Conjugated Polymers, Computed Properties of 1401018-41-4, the publication is Macromolecules (Washington, DC, United States) (2012), 45(19), 7799-7805, database is CAplus.

Sonogashira coupling of 9,9-bis(2-ethylhexyl)-2,7-diethynyl-9H-fluorene (1) with 2,7-dibromo-9,9-bis(2-ethylhexyl)-9H-fluorene (2) and dibromo-substituted electron accepting arylenes 5,7-bis(5-bromothiophen-2-yl)-2,3-dihexylthieno[3,4-b]pyrazine (3), 4,7-bis(5-bromo-4-(2-ethylhexyl)thiophene-2-yl)bis(benzothiadiazole) (4) or 4,9-bis(5-bromo-4-(2-ethylhexyl)thiophen-2-yl)-6,7-dihexylthiadiazolo[3,4-g]quinoxaline (5), resp., in a miniemulsion polymerization process afforded colloidally stable dispersions of poly(arylene ethynylene) nanoparticles with an average size in the range of 50 to 120 nm. For these poly[1-alt-(2-co-X)] (X = 3, 4, or 5), poly(1-alt-3), poly(1-alt-4), and poly(1-alt-5) aqueous nanoparticle dispersions absorption occurs increasingly in the red and NIR regime with increasing incorporation of acceptor monomer, with a strong absorption up to λ_abs = 1 μm for poly(1-alt-4) dispersions. For poly[1-alt-(2-co-3)] nanoparticles fluorescence is also observed at λ_em = ca. 700 nm, which occurs at this long wavelength exclusively even at an incorporation of only 1 mol % of 3 due to energy transfer to the low-energy chromophores. An alternative postpolymn. approach by change of solvent quality yielded dilute aqueous dispersions of self-stabilized nanoparticles from an amphiphilic block copolymer, poly(ethylene glycol)-block-poly(1-alt-6)-block-poly(ethylene glycol) generated from alkyne-terminated poly(1-alt-6) via azide-alkyne coupling (6 = 4,7-bis(5-bromo-4-(2-ethylhexyl)thiophene-2-yl)benzothiadiazole), which fluoresce at λ_em _max = 672 nm.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

He, Shasha’s team published research in Angewandte Chemie, International Edition in 60 | CAS: 1426829-76-6

Angewandte Chemie, International Edition published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, Related Products of benzothiophene.

He, Shasha published the artcileCharge-Reversal Polymer Nano-modulators for Photodynamic Immunotherapy of Cancer, Related Products of benzothiophene, the publication is Angewandte Chemie, International Edition (2021), 60(35), 19355-19363, database is CAplus and MEDLINE.

Nanomedicine can regulate the balance between cytotoxic T lymphocytes (CTLs) and suppressive regulatory T lymphocytes (Tregs), which however has been rarely exploited for cancer immunotherapy. We report a charge-reversal polymer nano-modulator (SPDMCN) activated by tumor microenvironment (TME) for photodynamic immunotherapy of cancer. SPDMCN is constructed by conjugating an immunomodulator (demethylcantharidin, DMC) to the side chains of a photodynamic polymer via an acid-liable linker. The neg. charge of SPDMCN ensures its high stability in blood circulation and ideal tumor accumulation; exposure to acidic TME reverses its surface charge to pos., enhancing tumor penetration and locally releasing DMC. Upon near-IR photoirradiation, SPDMCN generates singlet oxygen to ablate tumors and promote maturation of dendritic cells. Released DMC inhibits protein phosphatase 2 (PP2A) activity and decreases Tregs differentiation. Such combinational action induces a sharp increase in CTL/Treg ratio in TME and effectively inhibits both primary and distant tumors in living mice.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Wu, Yingtao’s team published research in Angewandte Chemie, International Edition in 61 | CAS: 628692-17-1

Angewandte Chemie, International Edition published new progress about 628692-17-1. 628692-17-1 belongs to benzothiophene, auxiliary class Boronic acid and ester,Benzothiophene,Benzothiophene,Boronic Acids,Boronic Acids,Boronic acid and ester, name is Benzo[b]thiophen-7-ylboronic acid, and the molecular formula is C12H14O2, Name: Benzo[b]thiophen-7-ylboronic acid.

Wu, Yingtao published the artcileSynthesis of Axially Chiral Aldehydes by N-Heterocyclic-Carbene-Catalyzed Desymmetrization Followed by Kinetic Resolution, Name: Benzo[b]thiophen-7-ylboronic acid, the publication is Angewandte Chemie, International Edition (2022), 61(14), e202117340, database is CAplus and MEDLINE.

Herein an NHC-catalyzed atroposelective esterification of biaryl dialdehydes as a general and practical strategy for the construction of axially chiral aldehydes I [Ar = Ph, 1-naphthyl, 9-phenanthryl, etc.; R¹ = Et, CH₂CF₃, cyclopropyl, etc.] was described. Mechanistic studies indicated that coupling proceeds through a novel combination of NHC-catalyzed desymmetrization of the dialdehydes and kinetic resolution This protocol featured excellent enantioselectivity, mild conditions, good functional-group tolerance and applicability to late-stage functionalization and provided a modular platform for the synthesis of axially chiral aldehydes and their derivatives

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Zhao, Wenchao’s team published research in Journal of the American Chemical Society in 139 | CAS: 1514905-24-8

Journal of the American Chemical Society published new progress about 1514905-24-8. 1514905-24-8 belongs to benzothiophene, auxiliary class Organic Photo-Voltaic Materials, OPV,BDT Donors, name is 4,8-Bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene, and the molecular formula is C15H23BO2, COA of Formula: C34H40F2S4.

Zhao, Wenchao published the artcileMolecular Optimization Enables over 13% Efficiency in Organic Solar Cells, COA of Formula: C34H40F2S4, the publication is Journal of the American Chemical Society (2017), 139(21), 7148-7151, database is CAplus and MEDLINE.

A new polymer donor (PBDB-T-SF) and a new small mol. acceptor (IT-4F) for fullerene-free organic solar cells (OSCs) were designed and synthesized. The influences of fluorination on the absorption spectra, mol. energy levels, and charge mobilities of the donor and acceptor were systematically studied. The PBDB-T-SF:IT-4F-based OSC device showed a record high efficiency of 13.1%, and an efficiency of over 12% can be obtained with a thickness of 100-200 nm, suggesting the promise of fullerene-free OSCs in practical applications.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Gibson, T’s team published research in Annals of the rheumatic diseases in 1980 | CAS: 40180-04-9

Annals of the rheumatic diseases published new progress in MEDLINE about 40180-04-9, 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Application of 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid.

Gibson, T published the artcileTienilic acid: a single treatment for hyperuricaemia and hypertension?, Application of 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, the main research area is .

Tienilic acid is a drug with established uricosuric and hypotensive properties. We have examined its potential role as a single treatment for hyperuricaemia and hypertension, 2 disorders which are commonly associated. In 17 subjects with gout, blood uric acid levels were reduced by approximately 50%. Eleven of these patients also had hypertension which was improved by tienilic acid. However, a statistically significant effect was observed only with standing diastolic blood pressure. Side effects included acute episodes of gout in 4 patients and transient loin pain and dysuria in 1 patient. The precipitation of gouty arthritis is an acknowledged risk of all potent hypouricaemic drugs. The hazard of urate deposition in the renal tract implicit in the history of loin pain is a more serious complication. Thus, it would appear that tienilic acid is a potentially valuable drug which may have a special role in patients with hyperuricaemia and hypertension. Further study is necessary to determine how it may be best administered without the risk of renal damage.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Reardon, J A’s team published research in Annals of the rheumatic diseases in 1980 | CAS: 40180-04-9

Reardon, J A published the artcileControlled inpatient study of tienilic acid in treatment of gout and hypertension., Application of 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, the main research area is .

Under inpatient controlled conditions 4 patients with gout and hypertension were treated with varying doses of tienilic acid, a new uricosuric diuretic. Plasma urate levels were reduced by an average of 50% in association with significantly increased urinary urate excretion. A twice-daily regimen was considerably more effective than a single morning dosage in reduction of plasma urate, though both regimens were equally effective in antihypertensive potency. The single daily regimen produced greater diurnal fluctuations in plasma urate and was more frequently associated with the development of acute gout attacks.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Wong, C M’s team published research in The Medical journal of Australia in 1981-03-07 | CAS: 40180-04-9

The Medical journal of Australia published new progress in MEDLINE about 40180-04-9, 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Computed Properties of 40180-04-9.

Wong, C M published the artcileComparison of the metabolic and antihypertensive properties of tienilic acid and hydrochlorothiazide., Computed Properties of 40180-04-9, the main research area is .

Tienilic acid (2,3-dichloro-4-(2-thienylcarbonyl) phenoxyacetic acid) is a new diuretic with uricosuric properties. Eighteen patients, aged between 37 and 67 years, with moderate arterial hypertension underwent a double-blind, within-patient, crossover study to compare the effects of tienilic acid (TNCF) and hydrochlorothiazide (HCTZ) on blood pressure, renal function, serum levels of uric acid and electrolytes, and liver function. Blood pressure was lowered similarly by TNCF and HCTZ. The prime advantage of TCNF over HCTZ was its profound hypouricaemic effect. Despite the possibility of hepatotoxicity of TNCF, it may still have a place in the treatment of hypertensive hyperuricaemic patients when the mechanism of hepatotoxicity of TNCF is elucidated.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Homberg, J C’s team published research in Clinical and experimental immunology in 1984 | CAS: 40180-04-9

Clinical and experimental immunology published new progress in MEDLINE about 40180-04-9, 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Synthetic Route of 40180-04-9.

Homberg, J C published the artcileA new anti-liver-kidney microsome antibody (anti-LKM2) in tienilic acid-induced hepatitis., Synthetic Route of 40180-04-9, the main research area is .

The sera of 131 patients with anti-liver-kidney microsome antibodies (anti-LKM) detected between 1973 and 1979 in two different laboratories were re-examined. (1) Eighty-six anti-LKM corresponded to the description given by Rizzetto, Swana & Doniach (1973), with a pattern of fluorescence predominating on the 3rd portion of the proximal tubules (P3). This group comprised 45 cases of idiopathic chronic hepatitis or idiopathic cirrhosis and one case of halothane-induced hepatitis. (2) Forty-five anti-LKM gave a different pattern on male mouse liver and male rat kidney: (a) fluorescence was greater on centrolobular than on periportal hepatocytes; (b) the first and second portions of proximal tubules (P1 and P2) predominated over P3; (c) P1 fluorescence was equally intense as P2 and (d) P3 cells were heterogeneous with one cell out of 20 more positive than the rest. Absorption tests confirmed that the corresponding antigen was also present in the liver microsomal fraction. A retrospective clinical study discovered tienilic acid-induced hepatitis in all cases. We suggest naming this new antibody ‘anti-LKM2’.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Murray, T G’s team published research in Clinical pharmacology and therapeutics in 1980 | CAS: 40180-04-9

Clinical pharmacology and therapeutics published new progress in MEDLINE about 40180-04-9, 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Safety of 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid.

Murray, T G published the artcileTicrynafen in anephric patients: effects on uric acid and pharmacokinetics., Safety of 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, the main research area is .

Ticrynafen was given to 6 anephric patients undergoing maintenance hemodialysis. Ticrynafen was given daily for the 3 days between hemodialyses. Ticrynafen had no effect on the interdialysis rise in serum uric acid levels. Ticrynafen did not accumulate in serum, but levels of metabolites continued to rise over the 3 days. Hemodialysis (5 hr) reduced levels of ticrynafen by 38% but had less effect on metabolite levels. There was no effect on serum cholesterol or triglycerides.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Eisalo, A’s team published research in Acta medica Scandinavica. Supplementum in 1982 | CAS: 40180-04-9

Acta medica Scandinavica. Supplementum published new progress in MEDLINE about 40180-04-9, 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, HPLC of Formula: 40180-04-9.

Eisalo, A published the artcileTienilic acid in patients with impaired renal function., HPLC of Formula: 40180-04-9, the main research area is .

Diuretic therapy is usually accompanied by biochemical changes, such as hypokalemia, impaired glucose tolerance and hyperuricaemia. Tienilic acid is a new long-acting diuretic with antihypertensive effect, combined with uricosuric property. For the purpose of evaluating the effect of tienilic acid in patients with impaired renal function, eleven patients with hypertension and slight to moderate renal impairment were randomized to either hydrochlorothiazide or tienilic acid therapy. During eight weeks of treatment no changes occurred in serum-creatinine, creatinine-clearance, serum-sodium, or urea. Despite renal impairment, serum uric acid decreased during tienilic acid treatment. Compared with placebo, a significant decrease in uric acid was seen as early as after one week of treatment (p less than 0.01) and after 8 weeks the difference was still of the same order (p less than 0.01). During hydrochlorothiazide therapy, serum uric acid increased progressively. The difference was p less than 0.002 at 4 weeks and p less than 0.0005 at 8 weeks of treatment, compared with placebo. The results of this study show that the uricosuric effect of tienilic acid is maintained in patients with mild to moderate renal impairment.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem