Tag: 100-200

Related Products of 88-15-3In 2020 ,《CF3SO2Na-Mediated, UV-Light-Induced Friedel-Crafts Alkylation of Indoles with Ketones/Aldehydes and Bioactivities of Products》 was published in Organic Letters. The article was written by Yang, Tianbao; Lu, Huiai; Shu, Yixuan; Ou, Yifeng; Hong, Ling; Au, Chak-Tong; Qiu, Renhua. The article contains the following contents:

A concise, one-step route to produce 3,3′-diindolylmethanes (DIMs) from simple indoles and ketones or aldehydes is reported. The key step is the ready formation of indole derivatives that involves the in situ conversion of CF3SO2Na reagent to ·CF3 under oxygen or air (1.0 atm) and UV irradiation It is disclosed that most of the obtained DIMs show anticancer activities in human bladder cancer cell lines EJ and T24. In the experiment, the researchers used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Related Products of 88-15-3)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Related Products of 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Reference of 1-Thiophen-2-yl-ethanoneIn 2019 ,《Rhodium-Catalyzed C-H/C-H Cross Coupling of Benzylthioethers or Benzylamines with Thiophenes Enabled by Flexible Directing Groups》 appeared in Organic Letters. The author of the article were Yang, Shiping; Cheng, Rui; Zhao, Tingxing; Luo, Anping; Lan, Jingbo; You, Jingsong. The article conveys some information:

Reported herein is an efficient synthetic protocol to ortho-functionalized 2-aryl thiophenes via Rh(III)-catalyzed C-H/C-H cross coupling of benzylthioethers or benzylamines with thiophenes. Both ortho- and meta-substituted benzylthioethers give monoheteroarylated products, while ortho-unhindered substrates mainly provide diheteroarylated benzylthioethers. The C-H/C-H cross coupling of benzylamines with thiophenes exclusively generates diheteroarylated benzaldehydes. Mechanistic study discloses a three-step tandem process involving the ortho-C-H diheteroarylation of benzylamine, the oxidation of benzylamine to imine, and the hydrolysis of imine to aldehyde. In the experimental materials used by the author, we found 1-Thiophen-2-yl-ethanone(cas: 88-15-3Reference of 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Reference of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Li, Hui; Su, Miaodong; Nie, Zhiwen; Yang, Tonglin; Luo, Weiping; Liu, Qiang; Guo, Cancheng published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《Effective [3+1+1+1] Cycloaddition to Six-Membered Carbocycle Based on DMSO as Dual Carbon Synthon》.Category: benzothiophene The article contains the following contents:

A [3+1+1+1] cycloaddition was developed among 2-arylpropenes RC(=CH2)CH3 (R = ethyloxidanyl, Ph, 4-nitrophenyl, etc.), ketones such as 3-oxo-3-phenylpropanenitrile, cyclohexanone, 1-phenylethan-1-one, etc. and DMSO in the presence of K2S2O8, wherein the 2-arylpropene provides three carbons, ketone offers one carbon, and DMSO as dual carbon donor contributes two carbons to the six-membered carbocycle. It gave the cyclohexene motif I (R1 = Ph, 2-nitrophenyl, thiophen-2-yl, etc.; R2 = H, CN, C(O)Ph) and spirocyclohexene skeleton e.g., II. Four C-C bonds formed in this process. Both propylene and ketone could be well tolerated and give the corresponding cyclohexene I or spirocyclohexene motif e.g., II in useful yields. Based on the controlled experiments, a possible mechanism was proposed. In the experiment, the researchers used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Category: benzothiophene)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Allen, Daniel; Callaghan, Owen; Cordier, Frederic L.; Dobson, David R.; Harris, John R.; Hotten, Terry M.; Owton, W. Martin; Rathmell, Richard E.; Wood, Virginia A. published their research in Tetrahedron Letters on December 20 ,2004. The article was titled 《An improved synthesis of substituted benzo[b]thiophenes using microwave irradiation》.COA of Formula: C9H5FO2S The article contains the following contents:

An easy and high-yielding method for the synthesis of substituted benzo[b]thiophenes using microwave irradiation is described. After reading the article, we found that the author used 4-Fluorobenzo[b]thiophene-2-carboxylic acid(cas: 310466-37-6COA of Formula: C9H5FO2S)

4-Fluorobenzo[b]thiophene-2-carboxylic acid(cas: 310466-37-6) belongs to benzothiophene.Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. COA of Formula: C9H5FO2SIt has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as selective estrogen receptor modulators, leukotriene synthesis inhibitors and antifungals, as well as in many natural products.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Application In Synthesis of 1-Thiophen-2-yl-ethanoneIn 2019 ,《Divergent synthesis and evaluation of the in vitro cytotoxicity profiles of 3,4-ethylenedioxythiophenyl-2-propen-1-one analogues》 was published in ChemMedChem. The article was written by Karunakaran, Jayachandran; Dhatchana Moorthy, Nachiappan; Chowdhury, Somenath Roy; Iqbal, Saleem; Majumder, Hemanta K.; Gunasekaran, Krishnasamy; Vellaichamy, Elangovan; Mohanakrishnan, Arasambattu K.. The article contains the following contents:

A new series of thiophene derivatives I [R = (E)-3,4,5-tri-MeOC6H2CH=CHC(O), 3,4,5-tri-MeOC6H2C(O), 2-amino-6-(4-bromophenyl)pyrimidin-4-yl, etc.; R1 = H, Me; R2 = H; R1R2 = O(CH2)2O; R3 = H, 2-thienyl] were synthesized by condensation reaction and evaluated for their in vitro cytotoxicity effects against five human cancer cell lines. Preliminary structure-activity relationships of compounds I were also established. The 3,4-ethylenedioxythiophene (EDOT)-appended enones demonstrated significant cytotoxicity against human cancer cell lines. The most active compound I [R = (E)-3,4,5-tri-MeOC6H2C(O)CH=CH; R1R2 = O(CH2)2O; R3 = H] (GI50=110 nM), severely inhibited clonogenic potential of cancer cells and induced cell-cycle arrest in G2/M phase and caused an accumulation of HCT116 colon cancer cells with >4 N DNA content. Also, compound I [R = (E)-3,4,5-tri-MeOC6H2C(O)CH=CH; R1R2 = O(CH2)2O; R3 = H] exhibited weak inhibition of the enzymic activity of human topoisomerase I. Mol. docking studies indicated preferential binding of the compounds I to ATP-binding pocket of human checkpoint 2 kinase (Chk2) catalytic domain, thus, identifying a novel diaryl 2-propenone chemotype for development of potent inhibitors of Chk2. The results came from multiple reactions, including the reaction of 1-Thiophen-2-yl-ethanone(cas: 88-15-3Application In Synthesis of 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Application In Synthesis of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Product Details of 88-15-3In 2021 ,《Ruthenium-catalyzed hydrogenation of aromatic ketones using chiral diamine and monodentate achiral phosphine ligands》 appeared in Catalysis Communications. The author of the article were Wang, Mengna; Zhang, Ling; Sun, Hao; Chen, Qian; Jiang, Jian; Li, Linlin; Zhang, Lin; Li, Li; Li, Chun. The article conveys some information:

The Ru-catalyzed asym. hydrogenation of ketones with chiral diamine and monodentate achiral phosphine has been developed. A wide range of ketones were hydrogenated to afford the corresponding chiral secondary alcs. in good to excellent enantioselectivities (up to 98.1% ee). In addition, an appropriate mechanism for the asym. hydrogenation was proposed and verified by NMR spectroscopy. In the experiment, the researchers used many compounds, for example, 1-Thiophen-2-yl-ethanone(cas: 88-15-3Product Details of 88-15-3)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Product Details of 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In 2019,New Journal of Chemistry included an article by Wang, Weifan; Luo, Man; Yao, Weiwei; Ma, Mengtao; Pullarkat, Sumod A.; Xu, Li; Leung, Pak-Hing. Recommanded Product: 88-15-3. The article was titled 《Catalyst-free and solvent-free hydroboration of ketones》. The information in the text is summarized as follows:

The hydroboration of a wide range of ketones with pinacolborane can be achieved under catalyst-free and solvent-free conditions to provide the corresponding boronic esters in quant. yields. A large gram-scale hydroboration of acetophenone with HBpin under the same conditions was also performed to afford the alc. product in a high yield thus demonstrating the scalability of the newly developed simple protocol. In the part of experimental materials, we found many familiar compounds, such as 1-Thiophen-2-yl-ethanone(cas: 88-15-3Recommanded Product: 88-15-3)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Recommanded Product: 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In 2019,Journal of Fluorescence included an article by Kolbus, Anna; Danel, Andrzej; Grabka, Danuta; Kucharek, Mateusz; Szary, Karol. Name: 1-Thiophen-2-yl-ethanone. The article was titled 《Spectral Properties of Highly Emissive Derivative of Coumarin with N,N-Diethylamino, Nitrile and Tiophenecarbonyl Moieties in Water-Methanol Mixture》. The information in the text is summarized as follows:

The new derivative of coumarin (E)-3-[7-(diethyloamino)-2-oxo-chromen-3yl]-2-(tiophene-2-carbonyl)prop-2-enenitrile (NOSQ) was easy synthesized with com. substrates as a result of the search of new Michael type addition sensors based on coumarins. Spectral properties of highly emissive NOSQ were investigated by steady state anal. (absorption and fluorescence measurements) and time-resolved anal. (fluorescence lifetime measurements). The effect of water-methanol mixture on the photophys. properties of the NOSQ mol. was analyzed. With increasing of volumetric fraction of water the intensity of absorbance and fluorescence was strongly reduced. The NOSQ quantum yield in methanol was quite high and the first portions of water caused a significant increase in this value. Water, which is usually a quencher, in this case caused the increase in the quantum yield. The fluorescence lifetimes had second-order decay and the values of fluorescence lifetime increased with increasing alc. content. D. functional theory (DFT) calculations and exptl. data remained in agreement and showed that the interaction between the NOSQ mol. and the solvent affects the appearance of the new conformer. The experimental part of the paper was very detailed, including the reaction process of 1-Thiophen-2-yl-ethanone(cas: 88-15-3Name: 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Name: 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In 2019,Dalton Transactions included an article by Ganguli, Kasturi; Shee, Sujan; Panja, Dibyajyoti; Kundu, Sabuj. Quality Control of 1-Thiophen-2-yl-ethanone. The article was titled 《Cooperative Mn(I)-complex catalyzed transfer hydrogenation of ketones and imines》. The information in the text is summarized as follows:

The synthesis and reactivity of Mn(I) complexes bearing bifunctional ligands comprising both the amine N-H and benzimidazole fragments I and II (R = H, Me; R1 = H, Me, phenyl; R2 = H, Me) are reported. Among the various ligands, the N-((1H-benzimidazol-2-yl)methyl)aniline ligand containing Mn(I) complex II (R = R2 = H; R1 = Ph) presented higher reactivity in the transfer hydrogenation (TH) of ketones R3C(O)R4 (R3 = Ph, thiophen-2-yl, cyclopropyl, etc.; R4 = Me, propan-2-yl, tert-Bu, etc.; R3R4 = 9H-fluoren-9-yl, 1,2,3,4-tetrahydronaphthalen-1-yl, cyclohexyl) in 2-propanol. Exptl., it was established that both the benzimidazole and amine N-H proton played a vital role in the enhancement of the catalytic activity. Utilizing this system, a wide range of ketones R3C(O)R4 and aldehydes R5CHO (R5 = 4-CH3C6H4, thiophen-2-yl, pentyl, etc.) was reduced efficiently. Notably, the TH of several imines R6R7C=NR8 (R6 = 4-OCH3C6H4, thiophen-2-yl, naphthalen-2-yl, etc.; R7 = H, Me, Et; R8 = C6H5, 4-OCH3C6H4, CH3(CH2)3, etc.), as well as chemoselective reduction of unsaturated ketones, was achieved in the presence of this catalyst. DFT calculations were carried out to understand the plausible reaction mechanism which disclosed that the transfer hydrogenation reaction followed a concerted outer-sphere mechanism. After reading the article, we found that the author used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Quality Control of 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Quality Control of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Kuzu, Burak; Ekmekci, Zeynep; Tan, Meltem; Menges, Nurettin published an article in 2021. The article was titled 《Excited State Intramolecular Proton Transfer (ESIPT)-Based Sensor for Ion Detection》, and you may find the article in Journal of Fluorescence.COA of Formula: C6H6OS The information in the text is summarized as follows:

C-2 and C-5 substituted imidazole skeleton was synthesized through a one-pot two-step strategy. Synthesized mol. emits the light on ESIPT (excited-state intramol. proton transfer). This mol. was utilized for its proton donor ability, and we have observed that fluoride and cyanide ions can be detected selectively. Different cations and anions were selected to observe the response of the synthesized mol. However, there were not any fluorometric and colorimetric response except for fluoride and cyanide ions. Detection limits of fluoride and cyanide ions were found to be 9.22μM and 11.48μM, resp. 1H-NMR spectra for the solution of the sensor and TBAF (tetrabuthylammoniumfluoride) were used for the identification of [L]-[HF2]- species. 3 equivalent TBAF saturated the solution of the sensor in d6-DMSO, and some of the proton resonances shifted to upfield due to the through-bond effect. The disappearance of NH proton with 0.5 equivalent TBAF or TBACN (tetrabuthylammoniumcyanide) showed that there was a proton abstraction by fluoride and cyanide ions, instead of the hydrogen bond. Solid-state application was utilized, and paper test strips were applied. Emission differences emerged when the sensor loaded strips were reacted with TBAF. Time resolved experiments revealed that solution of the sensor and TBAF in DMSO have multiexponential decay, and one of the lifetime was measured as 13.4 ns. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3COA of Formula: C6H6OS) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. COA of Formula: C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem