Tag: 100-200

Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety was written by Richardson, Timothy I.;Frank, Scott A.;Wang, Minmin;Clarke, Christian A.;Jones, Scott A.;Ying, Bai-Ping;Kohlman, Dan T.;Wallace, Owen B.;Shepherd, Timothy A.;Dally, Robert D.;Palkowitz, Alan D.;Geiser, Andrew G.;Bryant, Henry U.;Henck, Judith W.;Cohen, Ilene R.;Rudmann, Daniel G.;McCann, Denis J.;Coutant, David E.;Oldham, Samuel W.;Hummel, Conrad W.;Fong, Kin C.;Hinklin, Ronald;Lewis, George;Tian, Hongqi;Dodge, Jeffrey A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Reference of 90560-10-4 This article mentions the following:

Structure-activity relationship studies are described, which led to the discovery of novel selective estrogen receptor modulators (SERMs) for the potential treatment of uterine fibroids. The SAR studies focused on limiting brain exposure and were guided by computational properties. Compounds with limited impact on the HPO axis were selected using serum estrogen levels as a biomarker for ovarian stimulation. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Reference of 90560-10-4).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Reference of 90560-10-4

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer was written by Tria, George S.;Abrams, Tinya;Baird, Jason;Burks, Heather E.;Firestone, Brant;Gaither, L. Alex;Hamann, Lawrence G.;He, Guo;Kirby, Christina A.;Kim, Sunkyu;Lombardo, Franco;Macchi, Kaitlin J.;McDonnell, Donald P.;Mishina, Yuji;Norris, John D.;Nunez, Jill;Springer, Clayton;Sun, Yingchuan;Thomsen, Noel M.;Wang, Chunrong;Wang, Jianling;Yu, Bing;Tiong-Yip, Choi-Lai;Peukert, Stefan. And the article was included in Journal of Medicinal Chemistry in 2018.Formula: C9H8OS This article mentions the following:

In breast cancer, estrogen receptor alpha (ERα) pos. cancer accounts for approx. 74% of all diagnoses, and in these settings, it is a primary driver of cell proliferation. Treatment of ERα pos. breast cancer has long relied on endocrine therapies such as selective estrogen receptor modulators, aromatase inhibitors, and selective estrogen receptor degraders (SERDs). The steroid-based anti-estrogen fulvestrant, the only approved SERD, is effective in patients who have not previously been treated with endocrine therapy as well as in patients who have progressed after receiving other endocrine therapies. Its efficacy, however, may be limited due to its poor physicochem. properties. THe authors describe the design and synthesis of a series of potent benzothiophene-containing compounds that exhibit oral bioavailability and preclin. activity as SERDs. This article culminates in the identification of LSZ102 (I), a compound in clin. development for the treatment of ERα pos. breast cancer. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Formula: C9H8OS).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Formula: C9H8OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Geometry and Aromaticity in Highly Strained Heterocyclic Allenes: Characterization of a 2,3-Didehydro-2H-thiopyran was written by Nikitina, Asya F.;Sheridan, Robert S.. And the article was included in Organic Letters in 2005.COA of Formula: C9H5NS This article mentions the following:

The highly strained cyclic allene 2,3-didehydro-2H-thiopyran was generated by irradiation of matrix-isolated 2-benzothienylchlorocarbene and characterized by IR and UV/vis spectroscopy, in situ trapping, and DFT modeling. Calculations indicate that the allenic moiety in this system, although less aromatic in character, is relatively more stable than in the corresponding oxa system. It is suggested that the thio ring system can more readily accommodate the allenic geometry. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9COA of Formula: C9H5NS).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.COA of Formula: C9H5NS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Palladium-catalyzed synthesis of nitriles from N-phthaloyl hydrazones was written by Ano, Yusuke;Higashino, Masaya;Yamada, Yuki;Chatani, Naoto. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Application of 55219-11-9 This article mentions the following:

The Pd-catalyzed transformation of N-phthaloyl hydrazones into nitriles RC≡N [R = 3-pyridyl, 4-MeC₆H₄, 2-naphthyl, etc.] and R(Me)C=CHC≡N involving the cleavage of an N-N bond was reported. The use of N-heterocyclic carbene as a ligand was essential for the success of the reaction. N-Phthaloyl hydrazones prepared from aromatic aldehydes or cyclobutanones were applicable to this transformation, which gaves aryl nitriles RC≡N or alkenyl nitriles R(Me)C=CHC≡N, resp. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Application of 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Application of 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

5-Substituted Benzothiophenes: Synthesis, Mechanism, and Kinetic Studies was written by Cerminara, Iole;D’Alessio, Luciano;D’Auria, Maurizio;Funicello, Maria;Guarnaccio, Ambra. And the article was included in Helvetica Chimica Acta in 2016.Name: 6-Methoxybenzo[b]thiophene This article mentions the following:

The kinetics of the reaction of 4-methoxythiophenoxyacetaldehyde di-Et acetal, 4-nitrothiophenoxyacetaldehyde di-Et acetal, and 3-methoxythiophenoxyacetaldehyde di-Et acetal in polyphosphoric acid was explained. The kinetic behavior was explained from aided simulation and from d. functional theory calculations showing a different pathway for 4-nitrothiophenoxyacetaldehyde di-Et acetal and for 4-methoxythiophenoxyacetaldehyde di-Et acetal. In this last case, a very fast competing reaction to the dimerization product was observed In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Name: 6-Methoxybenzo[b]thiophene).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Name: 6-Methoxybenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A Transition-Metal-Free One-Pot Cascade Process for Transformation of Primary Alcohols (RCH₂OH) to Nitriles (RCN) Mediated by SO₂F₂ was written by Jiang, Ying;Sun, Bing;Fang, Wan-Yin;Qin, Hua-Li. And the article was included in European Journal of Organic Chemistry in 2019.Computed Properties of C9H5NS This article mentions the following:

Primary (benzylic) alcs. underwent transition-metal-free one-pot cascade process with SO₂F₂, K₂CO₃, and NH₂OH·HCl in DMSO to yield nitriles without introducing an addnl. carbon atom. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Computed Properties of C9H5NS).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Computed Properties of C9H5NS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Well-Defined Palladium N-Heterocyclic Carbene Complexes: Direct C-H Bond Arylation of Heteroarenes was written by Kumar, Anuj;Kumar, Manoj;Verma, Akhilesh K.. And the article was included in Journal of Organic Chemistry in 2020.Recommanded Product: 90560-10-4 This article mentions the following:

A series of palladium N-heterocyclic carbene (NHC) complexes of type trans-{(NHC)PdCl₂L} (L = C₅H₅N, 3-ClC₅H₄N, and PPh₃) have been developed as efficient precatalysts for direct C-H bond arylation of various heteroarenes. In particular, an in situ generated new NHC ligand derived from {1,3-bis(2,6-diethylphenyl)acenaphtho[1,2-d]imidazolium} chloride is used for the stabilization of the palladium metal center. Among the screened palladium precatalysts, the most active PEPPSI themed complex was successfully employed toward direct C-H bond arylation of various heteroarenes and aryl bromides. A range of functional groups on aryl bromides as well as on heteroarenes sustained throughout the standard reaction conditions for easy access of various arylated heterocyclic compounds Significantly, the utility of the protocol was demonstrated by the effective synthesis of a precursor of raloxifene, a selective estrogen receptor modulator. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Recommanded Product: 90560-10-4).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Recommanded Product: 90560-10-4

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity was written by Graham, Samuel L.;Shepard, Kenneth L.;Anderson, Paul S.;Baldwin, John J.;Best, Darryl B.;Christy, Marcia E.;Freedman, Mark B.;Gautheron, Pierre;Habecker, Charles N.. And the article was included in Journal of Medicinal Chemistry in 1989.Product Details of 90560-10-4 This article mentions the following:

Derivatives of 2-benzo[b]thiophenesulfonamide were prepared to investigate their utility as topically active inhibitors of ocular carbonic anhydrase for treating glaucoma. Among the compounds described are 6-hydroxy-2-benzo[b]thiophenesulfonamide and its acetate, which are among the most potent ocular hypotensives in this class, as assessed in the α-chymotrypsinized rabbit. These compounds were selected for clin. evaluation. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Product Details of 90560-10-4).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Product Details of 90560-10-4

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Efficient synthesis of 3-oxygenated benzothiophene derivatives was written by Zhang, Fuyao;Mitchell, David;Pollock, Patrick;Zhang, Tony Y.. And the article was included in Tetrahedron Letters in 2007.Reference of 90560-10-4 This article mentions the following:

An efficient synthesis of 2-bromo-3-(aryloxy)benzothiophene derivatives by a conjugate addition-elimination sequence of 2,3-dibromobenzothiophene dioxides with phenolic nucleophiles was developed. These benzothiophene derivatives serve as important intermediates for the synthesis of SERM (selective estrogen receptor modulator) analogs. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Reference of 90560-10-4).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Reference of 90560-10-4

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Small-Molecule Inhibitors of the TLR3/dsRNA Complex was written by Cheng, Kui;Wang, Xiaohui;Yin, Hang. And the article was included in Journal of the American Chemical Society in 2011.Application of 70060-13-8 This article mentions the following:

The protein-RNA interface has been regarded as “undruggable” despite its importance in many biol. processes. The toll-like receptor 3 (TLR3)/double-stranded RNA (dsRNA) complex provides an exciting target for a number of infectious diseases and cancers. We describe the development of a series of small-mol. probes that were shown to be competitive inhibitors of dsRNA binding to TLR3 with high affinity and specificity. In a multitude of assays, compound 4a was profiled as a potent antagonist to TLR3 signaling and also repressed the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β. In the experiment, the researchers used many compounds, for example, 5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8Application of 70060-13-8).

5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Application of 70060-13-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem