Tag: 100-200

Approaches to benzo[b]thiophenes by gas-phase pyrolysis of methyl 2-(alkylthio)cinnamates was written by Brown, Andrew;Cadogan, J. I. G.;MacPherson, Andrew D.;McNab, Hamish. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2007.Application of 55219-11-9 This article mentions the following:

Flash vacuum pyrolysis (FVP) of 3-[2-(tert.-butylthio)phenyl]propenoate at 700° (0.01 Torr) unexpectedly gave a mixture of benzo[b]thiophene (15%) Me 2,3-dihydrobenzo[b]thiophene-2-carboxylate (21%), and thiocoumarin (28%). Control experiments show that thiophenoxyls cyclize efficiently to benzo[b]thiophene under similar conditions. It follows that FVP of S-tert.-Bu derivatives of thiophenols, is not an efficient means of generating thiophenoxyl radicals owing to competing hydrogen capture processes. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Application of 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Application of 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Design, synthesis, and evaluation of novel 3,4-isoxazolediamide derivatives for the combination treatment of azole-resistant candidiasis was written by Liu, Lei;Sun, Yixiang;Gao, Zixuan;Yin, Wenbo;Jiang, Hong;Wu, Tianxiao;Sun, Yin;Qin, Qiaohua;Zhao, Dongmei;Cheng, Maosheng. And the article was included in Archiv der Pharmazie (Weinheim, Germany).SDS of cas: 70060-13-8 This article mentions the following:

Herein, the structural optimization and structure-activity relationship studies of 3,4-isoxazolediamide analogs I [R¹ = 4-FC₆H₄, 3-isoxazole, benzo(b)thien-2-yl, etc.] and II [R² = NHMe, NH(i-Pr), NMe₂, etc.] were reported. As a new class of fungal Hsp90 inhibitor, compound I [R¹ = 5-(morpholinomethyl)isoxazol-3-yl] was found to have good synergistic effects with fluconazole and to avoid potential mammalian toxicity. It also showed remarkable metabolic stability in vitro. Collectively, compound I [R¹ = 5-(morpholinomethyl)isoxazol-3-yl] could be a promising lead compound for drug discovery targeting fungal Hsp90 and deserves further investigation. In the experiment, the researchers used many compounds, for example, 5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8SDS of cas: 70060-13-8).

5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.SDS of cas: 70060-13-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Advances Toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT_1A receptor antagonism/SSRI activities. Part 2 was written by Takeuchi, Kumiko;Kohn, Todd J.;Honigschmidt, Nicholas A.;Rocco, Vincent P.;Spinazze, Patrick G.;Koch, Daniel J.;Atkinson, Steven T.;Hertel, Larry W.;Nelson, David L.;Wainscott, D. Bradley;Ahmad, Laura J.;Shaw, Janice;Threlkeld, Penny G.;Wong, David T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Recommanded Product: 90560-10-4 This article mentions the following:

Potent 5-HT1A/SSRIs at low nanomolar and subnanomolar concentrations were identified in a series of 1-(1H-indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols. Incorporation of an α-Me group in the piperidine ring with its specific stereochem. enhanced binding affinity at the 5-HT reuptake site and in vitro 5-HT_1A antagonist functional activity. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Recommanded Product: 90560-10-4).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Recommanded Product: 90560-10-4

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Regioselective synthesis of C3 alkylated and arylated benzothiophenes was written by Shrives, Harry J.;Fernandez-Salas, Jose A.;Hedtke, Christin;Pulis, Alexander P.;Procter, David J.. And the article was included in Nature Communications in 2017.COA of Formula: C9H5NS This article mentions the following:

The method for completely regioselective, metal-free C3 C-H functionalization of benzothiophenes e.g., I that utilizes synthetically unexplored benzothiophene S-oxides II (R¹ = H, 5-NO₂, 6-Br, etc.; R² = H, CO₂CH₃, CN, etc.), readily available from straightforward oxidation of benzothiophenes such as 5-bromobenzo[b]thiophene, 2-phenylbenzo[b]thiophene, 2-methylbenzo[b]thiophene, etc. and phenols such as p-cresol, 4-iodophenol, 4-nitrophenol, etc./propargyl silanes such as trimethyl(allyl)silane, trimethyl(2-bromoallyl)silane, 2-((trimethylsilyl)methyl)allyl acetate, etc. and allyl silanes such as propargyl silane, hex-1-yne-1,3-diylbis(trimethylsilane), hept-2-yn-1-yltrimethylsilane, etc. was described. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9COA of Formula: C9H5NS).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.COA of Formula: C9H5NS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors was written by Wang, Yuming;Li, Lijun;Fan, Jun;Dai, Yang;Jiang, Alan;Geng, Meiyu;Ai, Jing;Duan, Wenhu. And the article was included in Journal of Medicinal Chemistry in 2018.Computed Properties of C9H8OS This article mentions the following:

Fibroblast growth factor receptors (FGFR1-4) are promising therapeutic targets in many cancers. With the resurgence of interest in irreversible inhibitors, efforts have been directed to the discovery of irreversible FGFR inhibitors. Currently, several selective irreversible inhibitors are being evaluated in clin. trials that could covalently target a conserved cysteine in the P-loop of FGFR. In this article, the authors used a structure-guided approach that is rationalized by a computer-aided simulation to discover the novel and irreversible pan-FGFR inhibitor, 9g ((S)-1-(3-(4-amino-5-(7-methoxy-5-methylbenzo[b]thien-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidin-1-yl)prop-2-en-1-one), which provided superior FGFR in vitro activities and decent selectivity over VEGFR2 (vascular endothelia growth factor receptor 2). In in vivo studies, 9g displayed clear antitumor activities in NCI-H1581 and SNU-16 xenograft mice models. Addnl., the diluting method confirmed the irreversible binding of 9g to FGFR. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Computed Properties of C9H8OS).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Computed Properties of C9H8OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Benzo[b]naphtho[1,2-d]thiophene Sulfoxides: Biomimetic Synthesis, Photophysical Properties, and Applications was written by Shen, Xian-Yan;Li, Man;Zhou, Tai-Ping;Huang, Ji-Rong. And the article was included in Angewandte Chemie, International Edition in 2022.Safety of 5-Fluoro-1-benzothiophene-2-carboxylic acid This article mentions the following:

A practical synthesis of nonsym. thiophene-fused aromatic systems has been developed that was inspired by the biodegradation of benzothiophene. For the first time, the photophys. properties of a series of π-conjugated benzo[b]naphtho[1,2-d]thiophene (BNT) sulfoxides, I [R = H, Br, MeO, 4-FC₆H₄, R¹ = H, Br, Me, MeO, R² = Br, Cl, CN, etc., R³ = H, Br, MeO, Ph, 3-O₂NC₆H₄, 4-MeOC₆H₄, 4-FC₆H₄, R⁴ = H, Br, MeO, Ph, 3-O₂NC₆H₄, 4-MeOC₆H₄, 4-FC₆H₄, R⁵ = Br, Cl, 2-methoxy-3-pyridinyl, etc., R⁶ = H, Br, Me, R⁷ = H, Br, MeO, 4-FC₆H₄], were explored both in solution and in the solid state. The excellent fluorescence characteristics enable various applications of these compounds In the experiment, the researchers used many compounds, for example, 5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8Safety of 5-Fluoro-1-benzothiophene-2-carboxylic acid).

5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Safety of 5-Fluoro-1-benzothiophene-2-carboxylic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Near-ultraviolet absorption spectra of solutions of thianaphthene and some monoderivatives was written by Padhye, M. R.;Desai, S. R.. And the article was included in Transactions of the Faraday Society in 1953.COA of Formula: C9H8OS This article mentions the following:

The spectra of thianaphthene and 5-, 6-, and 7-monomethylthianaphthenes, chlorothianaphthenes, and methoxythianaphthenes in hexane solution were determined in a Beckman DU spectrophotometer, All solutions were 0.00025N in a 1-cm. cell. The effects of Me, Cl, and CH₃O substitution in different positions were systematized and compared with the effects of substitution on the spectrum of naphthalene. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4COA of Formula: C9H8OS).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.COA of Formula: C9H8OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Concise synthesis and biological evaluation of 2-Aryl-3-Anilinobenzo[b]thiophene derivatives as potent apoptosis-inducing agents was written by Romagnoli, Romeo;Preti, Delia;Hamel, Ernest;Bortolozzi, Roberta;Viola, Giampietro;Brancale, Andrea;Ferla, Salvatore;Morciano, Giampaolo;Pinton, Paolo. And the article was included in Bioorganic Chemistry in 2021.Formula: C9H8OS This article mentions the following:

Many clin. used agents active in cancer chemotherapy exert their activity through the induction of cell death (apoptosis) by targeting microtubules, altering protein function or inhibiting DNA synthesis. The benzo[b]thiophene scaffold holds a pivotal place as a pharmacophore for the development of anticancer agents, and, in addition, this scaffold has many pharmacol. activities. In the present study, a new series of 2-aryl-3-(3,4,5-trimethoxyanilino)-6-methoxybenzo[b]thiophenes I (R =H, 4-F, 4-CH₃ etc) are synthesized and the structure-activity relationship was examined by modification of the aryl group at its 2-position with electron-withdrawing (F) or electron-releasing (alkyl and alkoxy) groups. Authors found that small substituents, such as fluorine or Me, could be placed in the para-position of the 2-Ph ring, and these modifications only slightly reduced antiproliferative activity relative to the unsubstituted 2-Ph analog. Compounds I (R = H) and I (R = 4-F) exhibited the greatest antiproliferative activity among the tested compounds The treatment of both Caco2 (not metastatic) and HCT-116 (metastatic) colon carcinoma cells with I (R = H) and I (R = 4-F) triggered a significant induction of apoptosis. The same effect was not observed with non-transformed colon 841 CoN cells. A potential addnl. effect during mitosis for compound I (R = H) in metastatic cells and compound I (R = 4-F) in non-metastatic cells was also observed In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Formula: C9H8OS).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Formula: C9H8OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Transition-Metal-Free Synthesis of Heterobiaryls through 1,2-Migration of Boronate Complex was written by Paul, Swagata;Das, Kanak Kanti;Manna, Samir;Panda, Santanu. And the article was included in Chemistry – A European Journal in 2020.SDS of cas: 90560-10-4 This article mentions the following:

The synthesis of a diverse range of heterobiaryls has been achieved by a transition-metal-free sp²-sp² cross-coupling strategy using lithiated heterocycle, aryl or heteroaryl boronic ester and an electrophilic halogen source. The construction of heterobiaryls was carried out through electrophilic activation of the aryl-heteroaryl boronate complex, which triggered 1,2-migration from boron to the carbon atom. Subsequent oxidation of the intermediate boronic ester afforded heterobiaryls in good yield. A comprehensive ¹¹B NMR study has been conducted to support the mechanism. The cross coupling between two nucleophilic cross coupling partners without transition metals reveals a reliable manifold to procure heterobiaryls in good yields. Various heterocycles like furan, thiophene, benzofuran, benzothiophene, and indole are well tolerated. Finally, the gram scale synthesis of the intermediates for an anticancer drug and OLED material using this methodol. has been successfully demonstrated. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4SDS of cas: 90560-10-4).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.SDS of cas: 90560-10-4

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Copper-Catalyzed Oxidative C-C Bond Cleavage of Alkyl-(Hetero)arenes Enabling Direct Access to Nitriles was written by Xue, Gaijun;Xie, Fukai;Liang, Hongliang;Chen, Guoliang;Dai, Wen. And the article was included in Organic Letters in 2022.HPLC of Formula: 55219-11-9 This article mentions the following:

The cleavage and functionalization of C-C bonds has emerged as a powerful tool for discovery of new transformations. Herein, authors report a protocol that enables direct synthesis of nitriles via copper-catalyzed oxidative cleavage and cyanation of C-C bonds in a wide variety of multicarbon alkyl-substituted (hetero)arenes. Detailed mechanistic studies reveal that a tandem oxidative process is involved in this transformation. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9HPLC of Formula: 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.HPLC of Formula: 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem