Tag: 200-300

Photoinvertible Chiral Liquid Crystal that Affords Helicity-Controlled Aromatic Conjugated Polymers was written by Yoshida, Satoru;Morikawa, Santa;Ueda, Kenta;Hidaka, Masatomo;Kaneko, Kosuke;Kaneko, Kimiyoshi;Hanasaki, Tomonori;Akagi, Kazuo. And the article was included in Advanced Optical Materials in 2020.Category: benzothiophene This article mentions the following:

Photoinvertible chiral compounds are synthesized by linking a photoresponsive bisbenzothienylethene moiety with an axially chiral binaphthyl moiety and used as chiral dopants to prepare a photoinvertible chiral nematic liquid crystal (N*-LC) field. Subsequently, electrochem. polymerizations of ethylenedioxythiophene (EDOT) in the N*-LC field to synthesize helical poly(ethylenedioxythiophene)s (H-PEDOTs) are achieved. The H-PEDOTs show not only spiral morphologies resembling the fingerprinted texture of N*-LC in polarizing optical microscope but also bisignate Cotton effects in CD spectra, indicating the formation of a helically π-stacked structure in terms of the main chains of H-PEDOT. In addition, the signs of the bisignate Cotton effect are strictly determined by the helicity of the N*-LC. The present N*-LC is the first reaction field exhibiting photoinvertible chirality with extremely high fatigue resistance and serves as an asym. medium for electrochem. polymerization, leading to dynamic helicity control of conjugated polymers. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Category: benzothiophene).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is also used in the manufacturing of dyes such as thioindigo.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A convenient preparation of aryl trifluoromethyl ketones was written by DiMenna, William S.. And the article was included in Tetrahedron Letters in 1980.Category: benzothiophene This article mentions the following:

Seven thiophenyl, benzothiophenyl, and benzofuranyl trifluoromethyl ketones were prepared (40-75%) by reaction of CF₃CONMe₂ with aryllithium reagents, obtained by halogen metal exchange or direct metalation. E.g., 2-(trifluoroacetyl)benzo[b]thiophene was obtained (75%) by sequential treatment of benzo[b]thiophene with BuLi (Et₂O, 20°, reflux) and CF₃CONMe₂ (-85 to -65°, 1 h, 0°), followed by hydrolysis (H₂O, 3N HCl). In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Category: benzothiophene).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Aminobenzoannulated hetero- and carbocycles from 2-azahepta-2,4-dien-6-ynyllithium compounds: scope and limitation of a novel benzoannulation reaction was written by Lyaskovskyy, Volodymyr;Froehlich, Roland;Wuerthwein, Ernst-Ulrich. And the article was included in Synthesis in 2007.Recommanded Product: 6287-82-7 This article mentions the following:

Deprotonation of the N-benzylhetarylmethanimines, e.g. I (R¹ = n-Bu, Ph), at -78 °C with subsequent warming to room temperature over 16 h and treatment with electrophiles furnished polysubstituted aminobenzoannulated heterocycles, e.g. II (R² = H, Me), in good to excellent yields. In a similar fashion, the deprotonation of the N-allyl-2-(alk-1-ynyl)phenylmethanimines led to 1-amino-2-vinylnaphthalenes in moderate yields. The reaction of N-[(trimethylsilyl)methyl] imine of o-(phenylethynyl)benzaldehyde afforded naphthalen-1-amine unsubstituted at the ortho-position after removal of the trimethylsilyl group. The deprotonation of N-benzyl imine of o-(trimethylsilylethynyl)benzaldehyde gave none of expected amines, but the substituted imine, N-benzylidene-α-methyl-2-(trimethylsilyl)benzylamine, whose structure was identified using 2D NMR spectroscopy. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Recommanded Product: 6287-82-7).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Recommanded Product: 6287-82-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Supramolecular Assembly of Phosphole Oxide Based Alkynylplatinum(II) 2,6-Bis(N-alkylbenzimidazol-2′-yl)pyridine Complexes-An Interplay of Hydrophobicity and Aromatic π-Surfaces was written by Cheung, Andy Fu-Fai;Hong, Eugene Yau-Hin;Yam, Vivian Wing-Wah. And the article was included in Chemistry – A European Journal in 2018.COA of Formula: C8H4Br2S This article mentions the following:

A new class of phosphole oxide based alkynylplatinum(II) 2,6-bis(N-alkylbenzimidazol-2′-yl)pyridine (bzimpy) complexes were synthesized and characterized. Their self-assembly was driven by hydrophobic-hydrophobic and π-π stacking interactions. The self-assembly properties were also investigated by UV/Vis absorption spectroscopy, which revealed that the alkyl-chain length of the bzimpy moiety and the π-surface area of the alkynyl ligand have significant influence on the overall self-assembly process. The alkyl-chain length also affected the morphol. structures of the aggregates, which were studied by transmission electron microscopy and SEM. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7COA of Formula: C8H4Br2S).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.COA of Formula: C8H4Br2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The effects of heteroaryl ring on the photochromism of diarylethenes with a naphthalene moiety was written by Wang, Renjie;Pu, Shouzhi;Liu, Gang;Cui, Shiqiang;Li, Hui. And the article was included in Tetrahedron Letters in 2013.HPLC of Formula: 10243-15-9 This article mentions the following:

Three new asym. naphthalene-containing diarylethenes with different heteroaryl groups have been synthesized to investigate the heteroaryl effects on their properties. The three diarylethenes exhibited distinctive photochromism with good thermal stability, which may be attributed to the different heteroaryl effects. Their cycloreversion quantum yields increased in the order of 2-methylbenzofuran < 2-methylbenzothiophene < 1,2-dimethylindole, while the cyclization quantum yields exhibited a reverse trend. Compared to indole and benzothiophene, the benzofuran moiety could effectively shift the absorption maximum to a shorter wavelength and notably enhance the cyclization quantum yield and fluorescence quantum yield of the diarylethene. The results indicated that the category of heteroaryl groups played a vital role during the process of photoisomerization of naphthalene-containing diarylethene derivatives In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9HPLC of Formula: 10243-15-9).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is also used in the manufacturing of dyes such as thioindigo.HPLC of Formula: 10243-15-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Regioisomeric Effects of Donor-Acceptor-Acceptor’ Small-Molecule Donors on the Open Circuit Voltage of Organic Photovoltaics was written by Che, Xiaozhou;Chung, Chin-Lung;Liu, Xiao;Chou, Shu-Hua;Liu, Yi-Hung;Wong, Ken-Tsung;Forrest, Stephen R.. And the article was included in Advanced Materials (Weinheim, Germany) in 2016.Name: 2,3-Dibromobenzo[b]thiophene This article mentions the following:

We have elucidated the structure-property performance relationships of highly dipolar d-a-a’ small mols. used in organic donor-acceptor heterojunctions. Specifically, the mols. introduced with anti and syn asym. heteroacenes as coplanar donors of BTDC were used to investigate mol. regioisomeric effects on photogeneration efficiency when blended with fullerene acceptors. Both mols. pack in an antiparallel arrangement to achieve a centroymmetric dimer, leading to a net dipole moment of zero. The synBTDC with a shorter backbone conjugation length exhibits a reduced intra- and intermol. charge transfer compared with antiBTDC. An optimized OPV based on antiBTDC:C70 blend achieves VOC = 0.91 ^α 0.01 V, FF = 0.56 ^α 0.01, and PCE = 7.2 ^α 0.3%. Despite the reduced charge transfer and blue-shifted absorption which lead to smaller JSC, synBTDC shows a lower HOMO energy with higher VOC = 1.01 ^α 0.3 V, with a power conversion efficiency of 6.1 ^α 0.3%. The design of PYDC leads to a further enhanced VOC = 1.06 ^α 0.01 V due to the reduced quinoidal character of pyrimidine. We find that the VOC of the d-a-a’ donor:C70 devices is a function of the donor conjugation length: a reduction of backbone conjugation lowers the HOMO level for both groups of mols. with embedded benzothiadiazole or pyrimidine central “a” unit, leading to an enlarged donor-acceptor HOMO-LUMO gap and a larger VOC. Shortening the alkyl chains, or raising their LUMO energy for more complete exciton dissociation may lead to further improvements in FF, and ultimately the device performance. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Name: 2,3-Dibromobenzo[b]thiophene).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Name: 2,3-Dibromobenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway was written by Ji, Peng;Xu, Xin;Ma, Shuhua;Fan, Junchao;Zhou, Qiang;Mao, Xinliang;Qiao, Chunhua. And the article was included in ACS Medicinal Chemistry Letters in 2015.Formula: C10H7BrO2S This article mentions the following:

Signal transducer and activator of transcription 3 (STAT3) is considered to be an attractive therapeutic target for cancer therapy. In this study, a series of 2-carbonylbenzo[b]thiophene 1,1-dioxide derivatives (CBT) were designed to inhibit the STAT3 SH2 domain phosphorylation site Try 705. The authors demonstrated that incorporation of basic flexible groups through amide bond linkage to benzo[b]thiophene 1,1-dioxide (BTP) achieved compounds with higher antiproliferative potency than BTP itself. The most potent compound I, as indicated from luciferase reporter gene assay, inhibited the STAT3 pathway by decreasing the phosphorylation level of STAT3 Tyr705, while the phosphorylation level of other upstream tyrosine kinases in this pathway was not significantly inhibited. Compound I was also shown to trigger ROS generation and accumulation, thus consequently attributed partially to the observed cell apoptosis. This study provided important structural information for the development of inhibitors targeting the STAT3 pathway. In the experiment, the researchers used many compounds, for example, Methyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 7312-11-0Formula: C10H7BrO2S).

Methyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 7312-11-0) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Formula: C10H7BrO2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Sodium halides as the source of electrophilic halogens in green synthesis of 3-halo- and 3,n-dihalobenzo[b]thiophenes was written by Kesharwani, Tanay;Kornman, Cory;Tonnaer, Amanda;Hayes, Amanda;Kim, Seoyoung;Dahal, Nikesh;Romero, Ralf;Royappa, Andrew. And the article was included in Tetrahedron in 2018.Synthetic Route of C8H4Br2S This article mentions the following:

A convenient methodol. for the synthesis of mono- and di-halogenated benzo[b]thiophenes I (R = (CH₂)₃CH₃, C₆H₅, 4-H₃COC₆H₄, SiMe₃, cyclohex-2-en-1-yl, etc.; X = Cl, Br, I; X¹ = H, 4-Br, 5-Br, 6-Br, 7-Br), which utilizes copper(II) sulfate pentahydrate and various sodium halides NaX in the presence of substituted 2-alkynylthioanisoles 2-CH₃S-X¹C₆H₃CCR is described herein. The proposed method is facile, uses ethanol as a green solvent, and results in uniquely substituted benzo[b]thiophene I structures with isolated yields up to 96%. The most useful component of this methodol. is the selective introduction of bromine atoms at every available position (2-7) around the benzo[b]thiophene ring, while keeping position 3 occupied by a specific halogen atom such as Cl, Br or I. Aromatic halogens are useful reactive handles and therefore, the selective introduction of halogens at specific positions would be valuable in the targeted synthesis of bioactive mols. and complex organic materials via metal-catalyzed cross coupling reactions. This work is a novel approach towards the synthesis of dihalo substituted benzo[b]thiophenes I core structures, which provides a superior alternative to the current methods discussed herein. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Synthetic Route of C8H4Br2S).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Synthetic Route of C8H4Br2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A novel route to isoannulated heteroaromatic compounds 2. – The dipole route to furo/thieno pyrroles and α-pyridones, and their benzo derivatives was written by Bussenius, Jorg;Laber, Norbert;Muller, Thomas;Eberbach, Wolfgang. And the article was included in Chemische Berichte in 1994.COA of Formula: C8H4Br2S This article mentions the following:

A new methodol. involving 1,7-dipolar cyclizations of conjugated dipoles followed by a multistep rearrangement affording ring-contracted products has been employed for the synthesis of various examples of the title compounds Under different thermolysis conditions the annulated alkynyl nitrones are converted into isoannulated pyrroles and α-pyridones, resp., with yields up to 90%. The product distribution is strongly influenced by the nature of a terminal substituent R, hence supporting a mechanism with oxo carbenes as central intermediates which undergo either 6-π cyclization to the pyrrole systems of Wolff rearrangement leading to conjugates ketenes, the precursors of the observed α-pyridones. Diels-Alder reactions were performed with a benzofuropyridone derivative, naphthopyridone derivative, as well as with the corresponding dihydronaphtho compounds Whereas tert-Bu derivatives are rather un-reactive against dienophiles, they are easily transformed into cyclic imides under the influence of oxygen and light suggesting the formation and subsequent [4+2] cycloaddition of ¹O₂ as important steps. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7COA of Formula: C8H4Br2S).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.COA of Formula: C8H4Br2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis of functionalized benzothiophenes and dibenzothiophenes by two fold Heck and subsequent 6π-electrocyclization reactions of 2,3-dibromothiophenes and 2,3-dibromobenzothiophenes was written by Tengho Toguem, Serge-Mitherand;Malik, Imran;Hussain, Munawar;Iqbal, Jamshed;Villinger, Alexander;Langer, Peter. And the article was included in Tetrahedron in 2013.Electric Literature of C8H4Br2S This article mentions the following:

Benzothiophenes and dibenzothiophenes were prepared by two-fold Heck reactions of 2,3-dibromothiophene and 2,3-dibromobenzothiophene, resp., followed by thermal 6π-electrocyclization and dehydrogenative aromatization reactions. The Heck reaction of 2,3-dibromothiophene and 2,3-dibromobenzothiophene with 1 equiv of alkenes proceeded with different regioselectivities and afforded 2-alkenylthiophenes and 3-alkenylbenzothiophenes. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Electric Literature of C8H4Br2S).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Electric Literature of C8H4Br2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem