Tag: 200-300

The preparation of some heteroaromatic and aromatic aldehydes was written by Katritzky, Alan R.;He, Hai-Ying;Long, Qiuhe;Cui, Xilin;Level, Julian;Wilcox, Allan L.. And the article was included in ARKIVOC [online computer file] in 2000.Recommanded Product: 3-Bromo-2-methylbenzo[b]thiophene This article mentions the following:

Heteroaromatic α- and β-carboxaldehydes were prepared by the formylation with DMF of α-lithio benzofuran, benzothiophene, N-methylbenzimidazole and 10-methylphenothiazine obtained by direct lithiation and β-lithio compounds from lithium-bromine exchange. Dialkoxybenzaldehydes were prepared by the formylation of dialkoxybenzenes with hexamethylenetetramine (HMTA) or by the alkylation of dihydroxybenzaldehydes with alkyl bromides or iodides. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Recommanded Product: 3-Bromo-2-methylbenzo[b]thiophene).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Recommanded Product: 3-Bromo-2-methylbenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Reversible Photoswitching between Fluorescence and Room Temperature Phosphorescence by Manipulating Excited State Dynamics in Molecular Aggregates was written by Wang, Xuanhang;Pan, Guocui;Ren, Haoxuan;Li, Jiashu;Xu, Bin;Tian, Wenjing. And the article was included in Angewandte Chemie, International Edition in 2022.Synthetic Route of C8H4Br2S This article mentions the following:

Regulation of fluorescence-phosphorescence pathways in organic mol. aggregate remains a challenge due to the complicated singlet-triplet excited state dynamics process. Herein, we demonstrated a successful example (o-BFT) to realize photoreversible fluorescence and room temperature phosphorescence (RTP) switching based on an effective strategy of integrating a phosphor (dibenzofuran) with a photoswitch (dithienylbenzothiophene). o-BFT exhibited dual emission of fluorescence and RTP in both powder and doping polymer film. Notably, the long-lived RTP of o-BFT could be repeatedly erased and restored through reversible photocyclization and decyclization under alternate UV and visible photoirradiation In-depth theor. and spectroscopic investigations revealed that the triplet inactivation was dominated by a photo-controlled triplet-to-singlet Forster resonance energy transfer from light-activated o-BFT to photoisomer c-BFT. Yet, the initial fluorescence could be preserved in this process to afford a photoreversible fluorescence-RTP switching. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Synthetic Route of C8H4Br2S).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Synthetic Route of C8H4Br2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and photochromism studies of 1-(2-methyl-3-benzothiophenyl)-2-[2-methyl-5-(4-azidomethyl)-3-thienyl] perfluorocyclopentene was written by Tang, Yongjun;Xu, Hongyan;Pu, Shouzhi. And the article was included in Applied Mechanics and Materials in 2014.Related Products of 10243-15-9 This article mentions the following:

An unsym. photochromic diarylethene 1-(2-methyl-3-benzothiophenyl)-2-[2-methyl-5-(4-azidomethyl)-3-thienyl] perfluorocyclopentene was synthesized, and its optoelectronic properties were also investigated. The results showed that this compound exhibited reversible photochromism, changing from colorless to dark orange after irradiation with UV light in solution The open-ring isomer of the diarylethene 1o exhibited relatively strong fluorescence at 457 nm in acetonitrile solution (2 × 10-5 mol L-1) when excited at 287 nm. The fluorescence intensity decreased along with the photochromism upon irradiation with 297 nm light. The electrochem. properties indicated that the oxidation onset and the Eg of the open-ring isomer were lower than the closed-ring isomer. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9Related Products of 10243-15-9).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Related Products of 10243-15-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

One-pot synthesis and property study on thieno[3,2-b]furan compounds was written by Ma, Weimin;Huang, Jiawei;Li, Chao;Jiang, Yueren;Li, Baolin;Qi, Ting;Zhu, Xiaozhang. And the article was included in RSC Advances in 2019.Reference of 6287-82-7 This article mentions the following:

Based on the regioselective intermol. Suzuki coupling and subsequent intramol. Ullmann C-O coupling reactions, one-pot synthesis of benzo[4,5]thieno[3,2-b]benzofurans I (R¹ = H, 3-Cl, 2-n-octyl; R² = H, 8-F, 8-Me, 7-t-Bu) was developed after optimization of the reaction conditions including catalysts, solvents, bases, ligands and reaction times. The one-pot reaction, with only 2 mol% Pd(PPh₃)₄ and 2 mol% copper(I) thiophene-2-carboxylate as the catalysts, K₃PO₄·3H₂O as the base and tert-butanol as the solvent, afforded moderate to good yields (up to 70%) for a variety of substrates. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Reference of 6287-82-7).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Reference of 6287-82-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Efficient self-contained photoacid generator system based on photochromic terarylenes was written by Li, Ruiji;Nakashima, Takuya;Kanazawa, Rui;Galangau, Olivier;Kawai, Tsuyoshi. And the article was included in Chemistry – A European Journal in 2016.Name: 2,3-Dibromobenzo[b]thiophene This article mentions the following:

A series of highly sensitive neutral photoacid generators (PAGs) based on photochromic terarylenes was prepared Like the example presented herein, these compounds show a subsequent thermal elimination of a Bronsted acid after a light-triggered 6π-electrocyclization, concomitant with the hexatriene aromatization. A novel type of mol. systems was developed, in which one thiazolyl moiety was replaced by a thienyl group. Depending on the solvents and on the nature of the acid source, the quantum yield (QY) for acid generation could reach up to 0.6. Comparative studies on the acid source clearly showed that aromatic leaving groups tend to extinguish the mol. system photoefficiency. A second type was also prepared, in which the nature of the hetero-aromatic rings were identical to our previous example, but their sequence was modified. Therefore, a second level of improvement was achieved in nonpolar solvents, pushing the QY value up to 0.7. Finally, we demonstrated the mesylic acid-releasing PAG as a photocatalyst in a chem. amplified pos. resist system. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Name: 2,3-Dibromobenzo[b]thiophene).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Name: 2,3-Dibromobenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The considerable photostability improvement of photochromic terarylene by sulfone group was written by Jeong, Yong-Chul;Gao, Chunji;Lee, In Su;Yang, Sung Ik;Ahn, Kwang-Hyun. And the article was included in Tetrahedron Letters in 2009.Quality Control of 2,3-Dibromobenzo[b]thiophene This article mentions the following:

A photochromic terarylene benzothiophene derivative which has a sulfone group on the upper benzothiophene ring is readily synthesized using Suzuki coupling reaction. It exhibits good photochromic properties. Interestingly, the closed form of this benzothiophene dioxide compound shows a good photostability as well as a thermal stability compared with its reduced analog, that provides a method to enhance the photostability of versatile photochromic terarylenes under UV. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Quality Control of 2,3-Dibromobenzo[b]thiophene).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Quality Control of 2,3-Dibromobenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The base-catalyzed skeletal rearrangement of a thianaphthofluorene derivative was written by Cherry, W. H.;Davies, William;Ennis, B. C.;Porter, Quentin Noel. And the article was included in Australian Journal of Chemistry in 1967.Synthetic Route of C8H4Br2S This article mentions the following:

The Diels-Alder adduct of 3-vinylbenzo[b]thiophene and 1,4-naphthoquinone has been shown to undergo a novel base-catalyzed rearrangement, in which its partly hydrogenated 12-thianaphtho[2,3-a]fluorene structure is replaced by a 5-thianaphtho[2,3-b]fluorene (I) structure. 20 references. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Synthetic Route of C8H4Br2S).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Synthetic Route of C8H4Br2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors was written by Cai, Guiping;Yu, Wenying;Song, Dongmei;Zhang, Wenda;Guo, Jianpeng;Zhu, Jiawen;Ren, Yuhao;Kong, Lingyi. And the article was included in European Journal of Medicinal Chemistry in 2019.Computed Properties of C10H7BrO2S This article mentions the following:

STAT3 has been extensively studied as a potential antitumor target. Though studies on regulating STAT3 mainly focus on the inhibition of STAT3 phosphorylation at Tyr705 residue, the phosphorylation at Ser727 residue of STAT3 protein is also closely associated with the mitochondrial import of STAT3 protein. N, N-diethyl-7-aminocoumarin is a fluorescent mitochondria-targeting probe. In this study, a series of STAT3 inhibitors were developed by connecting N, N-diethyl-7-aminocoumarin fluorophore with benzo [b]thiophene 1, 1-dioxide moiety. All designed compounds displayed potent anti-proliferative activity against cancer cells. The representative compound 7a(I) was mainly accumulated in mitochondria visualized by its fluorescence. STAT3 phosphorylation was inhibited by I at both Tyr705 and Ser727 residues. I inhibited STAT3 phosphorylation whereas had no influence on the phosphorylation levels of STAT1, JAK2, Src and Erk1/2, indicating good selectivity of I. Moreover, I down-regulated the expression of STAT3 target genes Bcl-2 and Cyclin D1, increased ROS production and remarkably reduced the mitochondrial membrane potential to induce mitochondrial apoptotic pathway. Furthermore, I in vivo suppressed breast cancer 4T1 implanted tumor growth. Taken together, these results highlighted that I might be a promising mitochondria-targeting STAT3 inhibitor for cancer therapy. In the experiment, the researchers used many compounds, for example, Methyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 7312-11-0Computed Properties of C10H7BrO2S).

Methyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 7312-11-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Computed Properties of C10H7BrO2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Bis[1]benzothieno[2,3-d:2′,3′-d’]anthra[1,2-b:5,6-b’]dithiophene: synthesis, characterization, and application to organic field-effect transistors was written by Hyodo, Keita;Hagiwara, Hideki;Toyama, Ryota;Mori, Hiroki;Soga, Shin-ichi;Nishihara, Yasushi. And the article was included in RSC Advances in 2017.Recommanded Product: 6287-82-7 This article mentions the following:

We report the straightforward synthetic method and characterization of bis[1]benzothieno[2,3-d:2′,3′-d’]anthra[1,2-b:5,6-b’]dithiophene (BBTADT) having nine aromatic rings fused without solubilizing groups. The highest mobility of fabricated OFETs utilizing BBTADT exhibited 2.7 × 10^-2 cm² V^-1 s^-1 in polycrystalline films formed by vapor deposition, depending on the annealing temperatures of a substrate. In the experiment, the researchers used many compounds, for example, 2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7Recommanded Product: 6287-82-7).

2,3-Dibromobenzo[b]thiophene (cas: 6287-82-7) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Recommanded Product: 6287-82-7

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The considerable photostability improvement of photochromic terarylene by sulfone group was written by Jeong, Yong-Chul;Gao, Chunji;Lee, In Su;Yang, Sung Ik;Ahn, Kwang-Hyun. And the article was included in Tetrahedron Letters in 2009.HPLC of Formula: 10243-15-9 This article mentions the following:

A photochromic terarylene benzothiophene derivative which has a sulfone group on the upper benzothiophene ring is readily synthesized using Suzuki coupling reaction. It exhibits good photochromic properties. Interestingly, the closed form of this benzothiophene dioxide compound shows a good photostability as well as a thermal stability compared with its reduced analog, that provides a method to enhance the photostability of versatile photochromic terarylenes under UV. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9HPLC of Formula: 10243-15-9).

3-Bromo-2-methylbenzo[b]thiophene (cas: 10243-15-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.HPLC of Formula: 10243-15-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem